Octreotide inhibits capsaicin-induced activation of C and Aδ afferent fibres in rat hairy skin in vivo

Clinical and Experimental Pharmacology and Physiology

Volumn 38, Issue 8, 2011, Pages 521-527

  Wang, Jun ^a,b   Cao, Dong Yuan ^a,c   Guo, Yuan ^a   Ma, Shao Jie ^a   Luo, Rong ^a   Pickar, Joel G ^c   Zhao, Yan ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b HENAN UNIVERSITY   (China)

^c PALMER COLLEGE OF CHIROPRACTIC   (United States)

Author keywords

Afferent fibres; Capsaicin; Octreotide; Somatostatin receptor

Indexed keywords

CAPSAICIN; CYCLOSOMATOSTATIN; OCTREOTIDE; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; EVOKED RESPONSE; HAIR; IN VIVO STUDY; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NOCICEPTIVE RECEPTOR; NONHUMAN; RAT; SENSITIZATION; SENSORY NERVE; SENSORY NERVE CELL; SKIN NERVE; SKIN RECEPTOR; STIMULUS RESPONSE; THIN FILAMENT;

AFFERENT PATHWAYS; ANIMALS; CAPSAICIN; GASTROINTESTINAL AGENTS; HAIR; HOT TEMPERATURE; NERVE FIBERS; NERVE FIBERS, MYELINATED; NERVE FIBERS, UNMYELINATED; NEURAL CONDUCTION; NEURONS, AFFERENT; NOCICEPTORS; OCTREOTIDE; PAIN; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SOMATOSTATIN; SENSORY SYSTEM AGENTS; SKIN;

EID: 79960720519     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05542.x     Document Type: Article

References (57)

1. Epelbaum J. Somatostatin in the central nervous system: Physiology and pathological modifications. Prog. Neurobiol. 1986; 27: 63-100.
2. Szolcsanyi J, Pinter E, Helyes Z, Oroszi G, Nemeth J. Systemic anti-inflammatory effect induced by counter-irritation through a local release of somatostatin from nociceptors. Br. J. Pharmacol. 1998; 125: 916-22.
3. Szolcsanyi J, Helyes Z, Oroszi G, Nemeth J, Pinter E. Release of somatostatin and its role in the mediation of the anti-inflammatory effect induced by antidromic stimulation of sensory fibres of rat sciatic nerve. Br. J. Pharmacol. 1998; 123: 936-42.
4. Eschalier A, Aumaitre O, Ardid D, Fialip J, Duchene-Marullaz P. Long-lasting antinociceptive effect of RC-160, a somatostatin analog, in mice and rats. Eur. J. Pharmacol. 1991; 199: 119-21.
5. Corsi MM, Ticozzi C, Netti C et al. The effect of somatostatin on experimental inflammation in rats. Anesth. Analg. 1997; 85: 1112-5.
6. Chapman V, Dickenson AH. The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord. Neuropeptides 1992; 23: 147-52.
7. Carlton SM, Du J, Davidson E, Zhou S, Coggeshall RE. Somatostatin receptors on peripheral primary afferent terminals: Inhibition of sensitized nociceptors. Pain 2001; 90: 233-44.
8. Plourde V, Lembo T, Shui Z et al. Effects of the somatostatin analogue octreotide on rectal afferent nerves in humans. Am. J. Physiol. 1993; 265: G742-51.
9. Paice JA, Penn RD, Kroin JS. Intrathecal octreotide for relief of intractable nonmalignant pain: 5-year experience with two cases. Neurosurgery 1996; 38: 203-7.
10. Meynadier J, Chrubasik J, Dubar M, Wunsch E. Intrathecal somatostatin in terminally ill patients. A report of two cases. Pain 1985; 23: 9-12.
11. Chrubasik J, Meynadier J, Scherpereel P, Wunsch E. The effect of epidural somatostatin on postoperative pain. Anesth. Analg. 1985; 64: 1085-8.
12. Chuang HH, Prescott ED, Kong H et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4, 5)P2-mediated inhibition. Nature 2001; 411: 957-62.
13. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 1997; 389: 816-24.
14. Caterina MJ, Julius D. The vanilloid receptor: A molecular gateway to the pain pathway. Annu. Rev. Neurosci. 2001; 24: 487-517.
15. Hudson LJ, Bevan S, Wotherspoon G, Gentry C, Fox A, Winter J. VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur. J. Neurosci. 2001; 13: 2105-14.
16. Caterina MJ, Leffler A, Malmberg AB et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000; 288: 306-13.
17. Aoki Y, Ohtori S, Takahashi K et al. Expression and co-expression of VR1, CGRP, and IB4-binding glycoprotein in dorsal root ganglion neurons in rats: Differences between the disc afferents and the cutaneous afferents. Spine (Phila Pa 1976) 2005; 30: 1496-500.
18. Guo A, Vulchanova L, Wang J, Li X, Elde R. Immunocytochemical localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur. J. Neurosci. 1999; 11: 946-58.
19. Price TJ, Flores CM. Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse. J Pain 2007; 8: 263-72.
20. Carlton SM, Zhou S, Kraemer B, Coggeshall RE. A role for peripheral somatostatin receptors in counter-irritation-induced analgesia. Neuroscience 2003; 120: 499-508.
21. Guo Y, Yao FR, Cao DY et al. Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent thoracic segment in the rat. Brain Res. 2008; 1229: 61-71.
22. Wang J, Guo Y, Cao DY et al. Tonic inhibition of somatostatin on C and Aδ afferent fibers in rat dorsal skin in vivo. Brain Res. 2009; 1288: 50-9.
23. Luo R, Guo Y, Cao DY et al. Local effects of octreotide on glutamate-evoked activation of Aδ and C afferent fibers in rat hairy skin. Brain Res. 2010; 1322: 50-8.
24. Cain DM, Khasabov SG, Simone DA. Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: An in vivo study. J. Neurophysiol. 2001; 85: 1561-74.
25. Tian YL, Guo Y, Cao DY, Zhang Q, Wang HS, Zhao Y. Local application of morphine suppresses glutamate-evoked activities of C and Aδ afferent fibers in rat hairy skin. Brain Res. 2005; 1059: 28-34.
26. Zhang Q, Zhao Y, Guo Y et al. Activation and sensitization of C and Aδ afferent fibers mediated by P2X receptors in rat dorsal skin. Brain Res. 2006; 1102: 78-85.
27. Andrew D, Greenspan JD. Mechanical and heat sensitization of cutaneous nociceptors after peripheral inflammation in the rat. J. Neurophysiol. 1999; 82: 2649-56.
28. Horch KW, Tuckett RP, Burgess PR. A key to the classification of cutaneous mechanoreceptors. J Invest Dermatol 1977; 69: 75-82.
29. Ren Y, Zou X, Fang L, Lin Q. Sympathetic modulation of activity in Aδ- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats. J. Neurophysiol. 2005; 93: 365-77.
30. Baumann TK, Simone DA, Shain CN, LaMotte RH. Neurogenic hyperalgesia: The search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. J. Neurophysiol. 1991; 66: 212-27.
31. LaMotte RH, Lundberg LE, Torebjork HE. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. J. Physiol. 1992; 448: 749-64.
32. Carlton SM, Zhou S, Du J, Hargett GL, Ji G, Coggeshall RE. Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel. Pain 2004; 110: 616-27.
33. Li D, Ren Y, Xu X, Zou X, Fang L, Lin Q. Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related Peptide driven by dorsal root reflexes. J Pain 2008; 9: 1155-68.
34. Lin Q, Li D, Xu X, Zou X, Fang L. Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin. Mol Pain 2007; 3: 30.
35. Lin Q, Wu J, Willis WD. Dorsal root reflexes and cutaneous neurogenic inflammation after intradermal injection of capsaicin in rats. J. Neurophysiol. 1999; 82: 2602-11.
36. Ren Y, Zou X, Fang L, Lin Q. Involvement of peripheral purinoceptors in sympathetic modulation of capsaicin-induced sensitization of primary afferent fibers. J. Neurophysiol. 2006; 96: 2207-16.
37. Carlton SM, Coggeshall RE. Peripheral capsaicin receptors increase in the inflamed rat hindpaw: A possible mechanism for peripheral sensitization. Neurosci. Lett. 2001; 310: 53-6.
38. Ma QP. Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons. Neuroreport 2001; 12: 3693-5.
39. Tohda C, Sasaki M, Konemura T, Sasamura T, Itoh M, Kuraishi Y. Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity. J. Neurochem. 2001; 76: 1628-35.
40. Schulz S, Schreff M, Schmidt H, Handel M, Przewlocki R, Hollt V. Immunocytochemical localization of somatostatin receptor sst2A in the rat spinal cord and dorsal root ganglia. Eur. J. Neurosci. 1998; 10: 3700-8.
41. Hanesch U, Heppelmann B, Schmidt RF. Somatostatin-like immunoreactivity in primary afferents of the medial articular nerve and colocalization with substance P in the cat. J Comp Neurol 1995; 354: 345-52.
42. McNeill DL, Westlund KN, Coggeshall RE. Peptide immunoreactivity of unmyelinated primary afferent axons in rat lumbar dorsal roots. J. Histochem. Cytochem. 1989; 37: 1047-52.
43. O'Brien C, Woolf CJ, Fitzgerald M, Lindsay RM, Molander C. Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint. Neuroscience 1989; 32: 493-502.
44. Price J. An immunohistochemical and quantitative examination of dorsal root ganglion neuronal subpopulations. J. Neurosci. 1985; 5: 2051-9.
45. Fioravanti A, Govoni M, La Montagna G et al. Somatostatin 14 and joint inflammation: Evidence for intraarticular efficacy of prolonged administration in rheumatoid arthritis. Drugs Exp. Clin. Res. 1995; 21: 97-103.
46. Karalis K, Mastorakos G, Chrousos GP, Tolis G. Somatostatin analogues suppress the inflammatory reaction in vivo. J. Clin. Invest. 1994; 93: 2000-6.
47. Lembeck F, Donnerer J, Bartho L. Inhibition of neurogenic vasodilation and plasma extravasation by substance P antagonists, somatostatin and [D-Met2, Pro5]enkephalinamide. Eur. J. Pharmacol. 1982; 85: 171-6.
48. Davis KD, Meyer RA, Campbell JN. Chemosensitivity and sensitization of nociceptive afferents that innervate the hairy skin of monkey. J. Neurophysiol. 1993; 69: 1071-81.
49. Bar KJ, Schurigt U, Scholze A et al. The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats. Neuroscience 2004; 127: 197-206.
50. Hokfelt T, Elde R, Johansson O, Luft R, Nilsson G, Arimura A. Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat. Neuroscience 1976; 1: 131-6.
51. Lawson SN. Neuropeptides in morphologically and functionally identified primary afferent neurons in dorsal root ganglia: Substance P, CGRP and somatostatin. Prog. Brain Res. 1995; 104: 161-73.
52. Patel YC, Greenwood MT, Panetta R, Demchyshyn L, Niznik H, Srikant CB. The somatostatin receptor family. Life Sci. 1995; 57: 1249-65.
53. Koch BD, Blalock JB, Schonbrunn A. Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. I. An increase in potassium conductance is responsible for both the hyperpolarization and the decrease in intracellular free calcium produced by somatostatin. J. Biol. Chem. 1988; 263: 216-25.
54. Weckbecker G, Lewis I, Albert R, Schmid HA, Hoyer D, Bruns C. Opportunities in somatostatin research: Biological, chemical and therapeutic aspects. Nat. Rev. Drug Discov. 2003; 2: 999-1017.
55. Tentler JJ, Hadcock JR, Gutierrez-Hartmann A. Somatostatin acts by inhibiting the cyclic 3', 5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency. Mol. Endocrinol. 1997; 11: 859-66.
56. Cao DY, You HJ, Zhao Y et al. Involvement of peripheral ionotropic glutamate receptors in activation of cutaneous branches of spinal dorsal rami following antidromic electrical stimulation of adjacent afferent nerves in rats. Brain Res. Bull. 2007; 72: 10-7.
57. Zhang SH, Sun QX, Seltzer Z et al. Paracrine-like excitation of low-threshold mechanoceptive C-fibers innervating rat hairy skin is mediated by substance P via NK-1 receptors. Brain Res. Bull. 2008; 75: 138-45.