Immunocytochemical localization of somatostatin receptor sst2A in the rat spinal cord and dorsal root ganglia

European Journal of Neuroscience

Volumn 10, Issue 12, 1998, Pages 3700-3708

  Schulz, Stefan ^a   Schreff, Matthias ^a   Schmidt, Harald ^a   Händel, Manuela ^a   Przewlocki, Ryszard ^b   Höllt, Volker ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

Analgesia; Antibodies; Dorsal root ganglia; Immunocytochemistry; Octreotide; Somatostatin; Somatostatin receptor; Spinal cord

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; OCTREOTIDE; OPIATE RECEPTOR; POLYCLONAL ANTIBODY; RECEPTOR PROTEIN; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; SUBSTANCE P;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; DENDRITE; DORSAL RHIZOTOMY; DORSAL ROOT; GANGLION; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; INTRATHECAL DRUG ADMINISTRATION; MALE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CELLS, CULTURED; GANGLIA, SPINAL; GUINEA PIGS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; MOLECULAR SEQUENCE DATA; RABBITS; RATS; RATS, WISTAR; RECEPTORS, SOMATOSTATIN; SPINAL CORD;

EID: 0032466058     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00386.x     Document Type: Article

References (44)

1. Adams, J.C. (1992) Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. J. Histochem. Cytochem., 40, 1457-1463.
2. Arvidsson, U., Riedl, M., Chakrabarti, S., Lee, J.-H., Nakano, A.H., Dado, R., Loh, H., Law, P.-Y., Wessendorf, M. & Elde, R. (1995) Distribution and targeting of a mu opioid receptor (MOR1) in brain and spinal cord. J. Neurosci., 15, 3328-3341.
3. Bereiter, D.A., Benetti, A.P., Bereiter, D.F. & Hathaway, C.B. (1996) Central trigeminal effects of somatostatin and etorphine on adrenal and autonomic function in the cat. Am. J. Physiol., 270, R636-R644.
4. Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J. & Guillemin, R. (1973) Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science, 179, 77-79.
5. Breder, C.D., Yamada, Y., Yasuda, K., Seino, S., Saper, C. & Bell, G. (1992) Differential expression of somatostatin receptor subtypes in brain. J. Neurosci., 12, 3920-3934.
6. Bruno, J.F., Xu, Y., Song, J. & Berelowitz, M. (1992) Molecular cloning and functional expression of a brain-specific somatostatin receptor. Proc. Natl Acad. Sci. USA, 89, 11151-11155.
7. Chapman, V. & Dickenson, A.H. (1992) The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord. Neuropeptides, 23, 147-152.
8. Dado, R., Law, P.Y., Loh, H.H. & Elde, R. (1993) Immunofluorescent identification of a delta-opioid receptor on primary afferent nerve terminals. NeuroReport, 5, 341-344.
9. DeLecea, L., Criado, J.R., Prospero-Garcia, O., Gautvik, K.M., Schweitzer, P., Danielson, P.E., Dunlop, C.L.M., Siggins, G.R., Henriksen, S.J. & Sutcliffe, J.G. (1996) A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature, 381, 242-245.
10. Epelbaum, J., Aranciba, L.T., Kordon, C. & Enjalbert, A. (1982) Characterization, regional distribution, and subcellular distribution of (125 I) -Tyr1-somatostatin binding sites in rat brain. J. Neurochem., 38, 1515-1523.
11. Esclapez, M. & Houser, C.R. (1995) Somatostatin neurons are a subpopulation of GABA neurons in the rat dentate gyrus: evidence from colocalization of pre-prosomatostatin and glutamate decarboxylase messenger RNA. Neuroscience, 64, 339-355.
12. Havlicek, V., Rezek, M., Leybin, L. & Friesen, H. (1977) Analgesic effect of cerebroventricular administration of somatostatin. Fedn Proc., 36, 363.
13. Hökfelt, T., Efendic, S., Johannson, O., Luft, R. & Arimura, A. (1974) Immunohistochemical localization of somatostatin (growth-hormone release-inhibiting factor) in the guinea pig brain. Brain Res., 80, 165-169.
14. Holloway, S., Feniuk, W., Kidd, E.J. & Humphrey, P.P.A. (1996) A quantitative autoradiographical study on the distribution of somatostatin sst2 receptors in the rat central nervous system using (125 I) -BM-23027. Neuropharmacology, 35, 1109-1120.
15. Hoyer, D., Bell, G.I., Berelowitz, M., Epelbaum, J., Feniuk, W., Humphrey, P.P.A., O'Carroll, A.M., Patel, Y.C., Schonbrunn, A., Taylor, J.E. & Reisine, T. (1995) Classification and nomenclature of somatostatin receptors. Trends Pharmacol. Sci., 13, 61-69.
16. Hunyady, B., Hipkin, R.W., Schonbrunn, A. & Mezey, E. (1997) Immunocytochemical localization of somatostatin receptor sst2A in the rat pancreas. Endocrinology, 138, 2632-2635.
17. Johannson, O., Hökfelt, T. & Elde, P.R. (1984) Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat. Neuroscience, 13, 265-339.
18. Kluxen, F.W., Bruns, C. & Lübbert, H. (1992) Expression cloning of a rat brain somatostatin receptor cDNA. Proc. Natl Acad. Sci. USA, 89, 4618-4622.
19. Kong, H., DePaoli, A.M., Breder, C.D., Yasuda, K., Bell, G.I. & Reisine, T. (1994) Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2, and SSTR3 in adult rat brain: analysis by RNA blotting and in situ hybridization histochemistry. Neuroscience, 59, 175-184.
20. Lerner, R.A., Gree, N., Alexander, H., Liu, F.T., Sutcliffe, J.G. & Shinnick, T.M. (1981) Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc. Natl Acad. Sci. USA, 78, 3403-3407.
21. Martin, J.L., Chesselet, M.F., Raynor, K., Gonzales, C. & Reisine, T. (1991) Differential distribution of somatostatin receptor subtypes in rat brain revealed by newly developed somatostatin analogs. Neuroscience, 41, 581-593.
22. Maurer, R., Gaehwiler, B.H., Buescher, H., Hill, R.C. & Roemer, D. (1982) Opiate antagonistic properties of an octapeptide somatostatin analog. Proc. Natl Acad. Sci. USA, 79, 4815-4817.
23. Meyerhof, W., Wulfsen, I., Schönrock, C., Fehr, C. & Richter, D. (1992) Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of somatostatin-14 receptor in rat brain. Proc. Natl Acad. Sci. USA, 89, 10267-10271.
24. Mollenholt, P., Rawal, N., Gordh, T. Jr & Olsson, Y.T.I. (1994) Intrathecal and epidural somatostatin for patients with cancer. Analgesic effects and postmortem neuropathologic investigations of spinal cord and nerve roots. Anesthesiology, 81, 534-542.
25. Murase, K., Nedeljkov, V. & Randic, M. (1982) The actions of neuropeptides on dorsal horn neurons in the rat spinal cord slice preparation: an intracellular study. Brain Res., 234, 170-176.
26. O'Carroll, A.M., Lolait, S.J., Konig, M. & Mahan, L.C. (1992) Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. Mol Pharmacol., 42, 939-946.
27. Penn, R.D., Paice, J.A. & Krion, J.S. (1992) Octreotide: a potent new non-opiate analgesic for intrathecal infusion. Pain, 49, 13-19.
28. Perez, J., Rigo, M., Kaupmann, K., Bruns, C., Yasuda, K., Bell, G.I., Lübbert, H. & Hoyer, D. (1994) Localization of somatostatin (SRIF) SSTR-1, SSTR-2, and SSTR-3 receptor mRNA in rat brain by in situ hybridization. Naunyn-Schmiedebergs Arch. Pharmacol., 349, 145-160.
29. Randic, M. & Miletic, V. (1978) Depressant actions of methionine-enkephalin and somatostatin cat dorsal horn neurons activated by noxious stimuli. Brain Res., 152, 196-201.
30. Sandkuhler, J., Fu, Q.G. & Helmchen, C. (1990) Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: comparison with spinal morphine. Neuroscience, 34, 565-576.
31. Schindler, M., Sellers, L.A., Humphrey, P.P.A. & Emson, P.C. (1997) Immunohistochemical localization of the somatostatin sst2 (A) receptor in the rat brain and spinal cord. Neuroscience, 76, 225-240.
32. Schoeffter, P., Perez, J., Langenegger, D., Schupbach, E., Bobirnac, I., Lubbert, H., Bruns, C. & Hoyer, D. (1995) Characterization and distribution of somatostatin SS-1 and SRIF-1 binding sites in rat brain: identity with SSTR-2 receptors. Eur. J. Pharmacol., 289, 163-173.
33. Schulz, S., Schreff, M., Nüß, D. & Höllt, V. (1996) Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co-localization in pain-modulatory brain regions. NeuroReport, 7, 3021-3025.
34. Schulz, S., Schreff, M., Koch, T., Zimprich, A., Elde, R. & Höllt, V. (1998) Immunolocalization of two mu opioid receptor isoforms (MOR1 and MOR1B) in rat brain. Neuroscience, 82, 613-622.
35. Senaris, R.M., Humphrey, P.P. & Emson, P.C. (1994) Distribution of somatostatin receptors 1, 2 and 3 mRNA in rat brain and pituitary. Eur. J. Neurosci., 6, 1883-1896.
36. Sicuteri, F., Geppetti, P., Marabini, S. & Lembeck, F. (1984) Pain relief by somatostatin in attacks of cluster headache. Pain, 18, 359-365.
37. Sperk, G. & Widmann, R. (1984) Somatostatin precursor in the rat striatum: changes after local injection of kainic acid. J. Neurochem., 45, 1441-1447.
38. Taddese, A., Nah, S.Y. & McCleskey-E.W. (1995) Selective opioid inhibition of small nociceptive neurons. Science, 270, 1366-1369.
39. Uhl, G.R., Tran, V., Snyder, S.H. & Martin, J.B. (1985) Somatostatin receptors: distribution in rat central nervous system and human frontal cortex. J. Comp. Neurol., 240, 288-304.
40. Vanetti, M., Kouba, M., Wang, X., Vogt, G. & Höllt, V. (1992) Cloning and expression of a novel mouse somatostatin receptor (SSTR2B). FEBS Lett., 311, 290-294.
41. Vanetti, M., Vogt, G. & Höllt, V. (1993) The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization. FEBS Lett., 331, 260-266.
42. Wulfsen, I., Meyerhof, W., Fehr, S. & Richter, D. (1993) Expression patterns of rat somatostatin receptor genes in pre-and postnatal brain and pituitary. J. Neurochem., 61, 1549-1552.
43. Yamada, Y., Post, S.R., Wang, K., Tager, H.S., Bell, G.I. & Seino, S. (1992) Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc. Natl Acad. Sci. USA, 89, 251-255.
44. Yasuda, K., Rens-Domiano, S., Breder, C.D., Law, S.F., Saper, C.B., Reisine, T. & Bell, G.I. (1992) Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase J. Biol. Chem, 267, 20422-20428.