Crucial points within the pore as Determinants of K+ channel conductance and gating

Journal of Molecular Biology

Volumn 411, Issue 1, 2011, Pages 27-35

  Shi, Ning ^a   Zeng, Weizhong ^a   Ye, Sheng ^b   Li, Yang ^c   Jiang, Youxing ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

constriction point; electrostatics; single channel electrophysiology; steric hindrance

Indexed keywords

CALCIUM ION; POTASSIUM CHANNEL;

ARTICLE; BINDING SITE; CHANNEL GATING; CHEMICAL ANALYSIS; ELECTROPHYSIOLOGY; HYDRATION; MUTAGENESIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; STATIC ELECTRICITY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 79960697572     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.04.058     Document Type: Article

References (26)

1. Hille B. Ion Channels of Excitable Membranes 3rd edit. 2001 Sinauer Associates, Inc. Sunderland, MA
2. + channel signature sequence Biophys. J. 66 1994 1061 1067 (Pubitemid 24106352)
3. + channels Science 258 1992 1152 1155
4. + conduction and selectivity Science 280 1998 69 77 (Pubitemid 28169082)
5. + channel-Fab complex at 2.0 Å resolution Nature 414 2001 43 48 (Pubitemid 33041616)
6. Jiang Y., Lee A., Chen J., Cadene M., Chait B.T., and MacKinnon R. Crystal structure and mechanism of a calcium-gated potassium channel Nature 417 2002 515 522 (Pubitemid 34595912)
7. Jiang Y., Lee A., Chen J., Cadene M., Chait B.T., and MacKinnon R. The open pore conformation of potassium channels Nature 417 2002 523 526 (Pubitemid 34595913)
8. + channel pore Nat. Struct. Mol. Biol. 17 2010 1019 1023
9. Brelidze T.I., Niu X., and Magleby K.L. A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification Proc. Natl Acad. Sci. USA 100 2003 9017 9022 (Pubitemid 36899215)
10. Nimigean C.M., Chappie J.S., and Miller C. Electrostatic tuning of ion conductance in potassium channels Biochemistry 42 2003 9263 9268 (Pubitemid 36959233)
11. + channel with and without the gating ring J. Gen. Physiol. 129 2007 109 120 (Pubitemid 46184869)
12. Zadek B., and Nimigean C.M. Calcium-dependent gating of MthK, a prokaryotic potassium channel J. Gen. Physiol. 127 2006 673 685 (Pubitemid 43801314)
13. Parfenova L.V., Crane B.M., and Rothberg B.S. Modulation of MthK potassium channel activity at the intracellular entrance to the pore J. Biol. Chem. 281 2006 21131 21138 (Pubitemid 44115453)
14. + channels Cell 126 2006 1161 1173 (Pubitemid 44380293)
15. +-conducting channel Nature 440 2006 570 574
16. Alam A., and Jiang Y. High-resolution structure of the open NaK channel Nat. Struct. Mol. Biol. 16 2009 30 34
17. + channels causes epilepsy Nature 396 1998 687 690 (Pubitemid 29003948)
18. Singh N.A., Charlier C., Stauffer D., DuPont B.R., Leach R.J., and Melis R. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns Nat. Genet. 18 1998 25 29 (Pubitemid 28027874)
19. + channel Science 309 2005 897 903 (Pubitemid 41099919)
20. + channel in a lipid membrane-like environment Nature 450 2007 376 382 (Pubitemid 350126743)
21. + channel Nature 423 2003 33 41 (Pubitemid 36569577)
22. Beckstein O., and Sansom M.S. Liquid-vapor oscillations of water in hydrophobic nanopores Proc. Natl Acad. Sci. USA 100 2003 7063 7068 (Pubitemid 36706393)
23. Beckstein O., and Sansom M.S. The influence of geometry, surface character, and flexibility on the permeation of ions and water through biological pores Phys. Biol. 1 2004 42 52 (Pubitemid 44362317)
24. DeLano W.L. The PyMOL Molecular Graphics System 2002 DeLano Scientific San Carlos, CA http://www.pymol.org
25. Smart O.S., Goodfellow J.M., and Wallace B.A. The pore dimensions of gramicidin A Biophys. J. 65 1993 2455 2460 (Pubitemid 24005977)
26. Humphrey W., Dalke A., and Schulten K. VMD: visual molecular dynamics J. Mol. Graph. 14 1996 33 38 27-28 (Pubitemid 26152973)