Studies of the mechanistic details of the pH-dependent association of botulinum neurotoxin with membranes

Journal of Biological Chemistry

Volumn 286, Issue 30, 2011, Pages 27011-27018

  Mushrush, Darren J ^a   Koteiche, Hanane A ^a   Sammons, Morgan A ^a   Link, Andrew J ^a   Mchaourab, Hassane S ^a   Lacy, D Borden ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM NEUROTOXINS; C TERMINUS; CATALYTIC DOMAINS; CONFORMATIONAL CHANGE; CYTOSOLIC; CYTOSOLS; DATA SUPPORT; EUKARYOTIC CELLS; FLUORESCENCE QUENCHING; HYDROPHOBIC ENVIRONMENT; LARGE CLASS; PH-DEPENDENT; PROTEOLIPOSOMES; PROTEOLYTIC DEGRADATION; TOXIC PROTEINS;

LIPOSOMES; OLIGOMERS; PHOSPHOLIPIDS;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

BOTULINUM TOXIN; LIPOSOME;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; HYDROPHOBICITY; MEMBRANE BINDING; MEMBRANE MODEL; MEMBRANE STRUCTURE; MOLECULAR MECHANICS; NONHUMAN; PH; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; RESIDUE ANALYSIS; SPIN LABELING; TOXIN STRUCTURE;

BOTULINUM TOXINS, TYPE A; CYTOSOL; HYDROGEN-ION CONCENTRATION; MEMBRANES, ARTIFICIAL; MODELS, CHEMICAL; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT;

EUKARYOTA;

EID: 79960693436     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.256982     Document Type: Article

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