The cross-pathway control system regulates production of the secondary metabolite toxin, sirodesmin PL, in the ascomycete, Leptosphaeria maculans

BMC Microbiology

Volumn 11, Issue , 2011, Pages

  Elliott, Candace E ^a   Fox, Ellen M ^a,b   Jarvis, Renee S ^a   Howlett, Barbara J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Department of Sustainability and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

SIRODESMIN PL; TOXIN; UNCLASSIFIED DRUG; AMINO ACID; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; FUNGAL DNA; PIPERAZINE DERIVATIVE; SIRODESMIN;

ARTICLE; ASCOMYCETES; ASPERGILLUS FUMIGATUS; CONTROL SYSTEM; CROSS PATHWAY CONTROL SYSTEM; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; GENETIC TRANSCRIPTION; LEPTOSPHAERIA MACULANS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN MALNUTRITION; BIOSYNTHESIS; CHEMISTRY; DNA SEQUENCE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY;

ASPERGILLUS FUMIGATUS; LEPTOSPHAERIA MACULANS;

AMINO ACIDS; ASCOMYCOTA; ASPERGILLUS FUMIGATUS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BIOSYNTHETIC PATHWAYS; DNA, FUNGAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PIPERAZINES; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79960685159     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-11-169     Document Type: Article

References (31)

1. Biological effects of Sirodesmin-PL, a phytotoxin produced by Leptosphaeria maculans. Rouxel T, Chupeau Y, Fritz R, Kollmann A, Bousquet JF, Plant Sci 1988 57 45 53 10.1016/0168-9452(88)90140-9
2. Production of the toxin sirodesmin PL by Leptosphaeria maculans during infection of Brassica napus. Elliott CE, Gardiner DM, Thomas G, Cozijnsen A, Van de Wouw AP, Howlett BJ, Mol Plant Pathol 2007 8 791 802 10.1111/j.1364-3703. 2007.00433.x 20507539 (Pubitemid 47568900)
3. The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis. Gardiner DM, Waring P, Howlett BJ, Microbiology-Sgm 2005 151 1021 1032 10.1099/mic.0.27847-0 (Pubitemid 40568000)
4. 1 NMR chemical shift determines beta-proton exchange in tyrosine. Pedras MSC, Yu Y, Can J Chem 2009 87 4 564 570
5. A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL. Kremer A, Li SM, Microbiology-Sgm 2010 156 278 286 10.1099/mic.0.033886-0
6. The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans. Gardiner DM, Cozijnsen AJ, Wilson LM, Pedras MS, Howlett BJ, Mol Microbiol 2004 53 1307 1318 10.1111/j.1365-2958.2004.04215.x 15387811 (Pubitemid 39209106)
7. Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus. Gardiner DM, Howlett BJ, FEMS Microbiol Lett 2005 248 241 248 10.1016/j.femsle.2005.05.046 15979823 (Pubitemid 40942134)
8. Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. Cramer RA, Gamcsik MP, Brooking RM, Najvar LK, Kirkpatrick WR, Patterson TF, Balibar CJ, Graybill JR, Perfect JR, Abraham SN, Steinbach WJ, Eukaryot Cell 2006 5 972 980 10.1128/EC.00049-06 16757745 (Pubitemid 43895027)
9. The gliP gene of Aspergillus fumigatus is essential for gliotoxin production but has no effect on pathogenicity of the fungus in a mouse infection model of invasive aspergillosis. Kupfahl C, Heinekamp T, Geginat G, Ruppert T, Hartel A, Hof H, Brakhage AA, Int J Med Microbiol 2006 296 73 73 10.1016/j.ijmm.2006.01.036 16476569 (Pubitemid 43375989)
10. GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Bok JW, Chung D, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Kirby KA, Keller NP, Infect Immun 2006 74 6761 6768 10.1128/IAI.00780-06 17030582 (Pubitemid 44913150)
11. A Zn(II)(2)Cys(6) DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans. Fox EM, Gardiner DM, Keller NP, Howlett BJ, Fungal Genet Biol 2008 45 671 682 10.1016/j.fgb.2007.10.005 18023597 (Pubitemid 351484257)
12. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Natarajan K, Meyer MR, Jackson BM, Slade D, Roberts C, Hinnebusch AG, Marton MJ, Mol Cell Biol 2001 21 4347 4368 10.1128/MCB.21.13.4347-4368.2001 11390663 (Pubitemid 32565316)
13. Transcriptional autoregulation and inhibition of mRNA translation of amino acid regulator gene cpcA of filamentous fungus Aspergillus nidulans. Hoffmann B, Valerius O, Andermann M, Braus GH, Mol Biol Cell 2001 12 2846 2857 11553722 (Pubitemid 33051948)
14. The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Krappmann S, Bignell EM, Reichard U, Rogers T, Haynes K, Braus GH, Mol Microbiol 2004 52 785 799 10.1111/j.1365-2958.2004.04015.x 15101984 (Pubitemid 38621748)
15. Mutation of a gene in the fungus Leptosphaeria maculans allows increased frequency of penetration of stomatal apertures of Arabidopsis thaliana. Elliott CE, Howlett BJ, Mol Plant 2008 1 471 481 10.1093/mp/ssn014 19825554
16. HPLC analyses of cultures of Phoma spp.: Differentiation among groups and species through secondary metabolite profiles. Pedras M, Biesenthal CJ, Can J Microbiol 2000 46 685 691 10941513 (Pubitemid 30663870)
17. Synergism of aminotriazole and phosphate on inhibition of yeast imidazole glycerol phosphate dehydratase. Klopotowski T, Wiater A, Arch Biochem Biophys 1965 112 562 566 10.1016/0003-9861(65)90096-2 5880156
18. HAR07 encodes chorismate mutase of the methylotrophic yeast Hansenula polymorpha and is derepressed upon methanol utilization. Krappmann S, Pries R, Gellissen G, Hiller M, Braus GH, J Bacteriol 2000 182 4188 4197 10.1128/JB.182.15.4188-4197.2000 10894726 (Pubitemid 30463781)
19. Secondary metabolism: regulation and role in fungal biology. Fox EM, Howlett BJ, Curr Opin Microbiol 2008 11 481 487 10.1016/j.mib.2008.10.007 18973828
20. LaeA, a regulator of morphogenetic fungal virulence factors. Bok JW, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Keller NP, Eukaryot Cell 2005 4 1574 1582 10.1128/EC.4.9.1574-1582.2005 16151250 (Pubitemid 41339112)
21. Transcriptional profiling of Saccharomyces cerevisiae cells under adhesion-inducing conditions. Kleinschmidt M, Grundmann O, Bluthgen N, Mosch HU, Braus GH, Mol Genet Genomics 2005 273 382 393 10.1007/s00438-005-1139-4 15843968 (Pubitemid 40922403)
22. The cross-pathway control gene of Neurospora crassa cpc-1, encodes a protein similar to GCN4 of yeast and the DNA-binding domain of the oncogene v-jun encoded protein. Paluh JL, Orbach MJ, Legerton TL, Yanofsky C, Proc Natl Acad Sci USA 1988 85 3728 3732 10.1073/pnas.85.11.3728 2967496
23. Cpc1 mediates cross-pathway control independently of Mbf1 in Fusarium fujikuroi. Schönig B, Vogel S, Tudzynski B, Fungal Genet Biol 2009 46 898 908 10.1016/j.fgb.2009.08.003 19679194
24. Transcriptional profiling of cross pathway control in Neurospora crassa and comparative analysis of the Gcn4 and CPC1 regulons. Tian CG, Kasuga T, Sachs MS, Glass NL, Eukaryot Cell 2007 6 1018 1029 10.1128/EC.00078-07 17449655 (Pubitemid 46983301)
25. Global role of the protein kinase Gcn2 in the human pathogen Candida albicans. Tournu H, Tripathi G, Bertram G, Macaskill S, Mavor A, Walker L, Odds FC, Gow NAR, Brown AJP, Eukaryot Cell 2005 4 1687 1696 10.1128/EC.4.10.1687- 1696.2005 16215176 (Pubitemid 41484228)
26. Multiple upstream AUG codons mediate translational control of GCN4. Mueller PP, Hinnebusch AG, Cell 1986 45 201 207 10.1016/0092-8674(86)90384-3 3516411 (Pubitemid 16043423)
27. Nitrogen metabolite signalling involves the C-terminus and the GATA domain of the Aspergillus transcription factor AREA and the 3' untranslated region of its mRNA. Platt A, Langdon T, Arst HN, Kirk D, Tollervey D, Sanchez JMM, Caddick MX, EMBO J 1996 15 2791 2801 8654376
28. Impact of the cross-pathway control on the regulation of lysine and penicillin biosynthesis in Aspergillus nidulans. Busch S, Bode HB, Brakhage AA, Braus GH, Curr Genet 2003 42 209 219 12589472 (Pubitemid 36221641)
29. Deletion of the Gibberella fujikuroi glutamine synthetase gene has significant impact on transcriptional control of primary and secondary metabolism. Teichert S, Schonig B, Richter S, Tudzynski B, Mol Microbiol 2004 53 1661 1675 10.1111/j.1365-2958.2004.04243.x 15341646 (Pubitemid 39265313)
30. What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus? Kwon-Chung KJ, Sugui JA, Med Mycol 2009 47 97 S103 10.1080/13693780802056012 18608908
31. The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. Morton CO, Varga JJ, Hornbach A, Mezger M, Sennefelder H, Kneitz S, Kurzai O, Krappmann S, Einsele H, Nierman WC, Rogers TR, Loeffler J, PLoS One 2011 6 16106 10.1371/journal.pone.0016106 21283711