Impact of the cross-pathway control on the regulation of lysine and penicillin biosynthesis in Aspergillus nidulans

Current Genetics

Volumn 42, Issue 4, 2003, Pages 209-219

  Busch, Silke ^a   Bode, Helge B ^a   Brakhage, Axel A ^b   Braus, G H ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b LEIBNIZ UNIVERSITY HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOADIPIC ACID; ACONITATE HYDRATASE; BETA LACTAM ANTIBIOTIC; GENE PRODUCT; LYSINE; PENICILLIN G; SACCHAROPINE DEHYDROGENASE;

AMINO ACID ANALYSIS; AMINO ACID SYNTHESIS; ANTIBIOTIC BIOSYNTHESIS; ASPERGILLUS NIDULANS; CATALYSIS; CONTROLLED STUDY; FUNGAL METABOLISM; FUNGAL STRAIN; GENE EXPRESSION; GENE IDENTIFICATION; GENE ISOLATION; GENETIC CODE; GENETIC TRANSCRIPTION; METABOLITE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPORTER GENE; REVIEW; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION;

ASPERGILLUS; ASPERGILLUS NIDULANS; EMERICELLA NIDULANS; FUNGI;

EID: 0037278470     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-002-0333-8     Document Type: Review

References (50)

1. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402
2. Banuelos O, Casqueiro J, Fierro F, Hijarrubia MJ, Gutierrez S, Martin JF (1999) Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase. Gene 226: 51-59
3. Banuelos O, Casqueiro J, Gutierrez S, Martin JF (2000) Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, alpha-aminoadipic acid pool and penicillin production. Appl Microbiol Biotechnol 54: 69-77
4. Bennett JW, Lasure LL (1991) Growth media. In: Bennett JW, Lasure LL (eds) More gene manipulation in fungi. Academic Press, San Diego, pp 441-457
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
6. Brakhage AA (1998) Molecular regulation of beta-lactam biosynthesis in filamentous fungi. Microbiol Mol Biol Rev 62:547-585
7. Brakhage AA, Turner G (1992) L-lysine repression of penicillin biosynthesis and the expression of penicillin biosynthesis genes acvA and ipnA in Aspergillus nidulans. FEMS Microbiol Lett 77: 123-127
8. Brakhage AA, Browne P, Turner G (1992) Regulation of Aspergillus nidulans penicillin biosynthesis and penicillin biosynthesis genes acvA and ipnA by glucose. J Bacteriol 174: 3789-3799
9. Busch S, Hoffmann B, Valerius O, Starke K, Düvel K, Braus GH (2001) Regulation of the Aspergillus nidulans hisB gene by histidine starvation. Curr Genet 38: 314-322
10. Casqueiro J, Gutierrez S, Banuelos O, Hijarrubia MJ, Martin JF (1999) Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction. J Bacteriol 181: 1181-1188
11. Corpet F (1988) Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res 16: 10881-10890
12. Eckert SE, Kübler E, Hoffmann B, Braus GH (2000) The tryptophan synthase-encoding trpB gene of Aspergillus nidulans is regulated by the cross-pathway control system. Mol Gen Genet 263: 867-876
13. Felenbok B, Flipphi M, Nikolaev I (2001) Ethanol catabolism in Aspergillus nidulans: a model system for studying gene regulation. Prog Nucleic Acid Res Mol Biol 69: 149-204
14. Firn RD, Jones CG (2000) The evolution of secondary metabolism - a unifying model. Mol Microbiol 37: 989-994
15. Garrad R, Schmidt TM, Bhattacharjee JK (1994) Molecular and functional analysis of the LYS1 gene of Candida albicans. Infect Immun 62: 5027-5031
16. Gentles S, Churcher CM, Barrell BG, Rajandream MA, Walsh SV (1995) SwissProt accession number 09694
17. Hinnebusch AG (1986) The general control of amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae. Crit Rev Biochem 21: 277-317
18. Hoffmann B, Valerius O, Andermann M, Braus GH (2001) Transcriptional autoregulation and inhibition of mRNA translation of amino acid regulator gene cpcA of filamentous fungus Aspergillus nidulans. Mol Biol Cell 12: 2846-2857
19. Hönlinger C, Kubicek CP (1989) Regulation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine and isopenicillin N biosynthesis in Penicillium chrysogenum by the alpha-aminoadipate pool size. FEMS Microbiol Lett 53: 71-75
20. Hönlinger C, Hampel WA, Rohr M, Kubicek CP (1988) Differential effects of general amino acid control of lysine biosynthesis on penicillin formation in strains of Penicillium chrysogenum. J Antibiot (Tokyo) 41: 255-257
21. Jaklitsch WM, Hampel W, Rohr M, Kubicek CP, Gamerith G (1986) Alpha-aminoadipate pool concentration and penicillin biosynthesis in strains of Penicillium chrysogenum. Can J Microbiol 32: 473-480
22. Käfer E (1977) Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations. Adv Genet 19: 33-131
23. Kennedy J, Turner G (1996) Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate-limiting enzyme for penicillin production in Aspergillus nidulans. Mol Gen Genet 253: 189-197
24. Krappmann S, Helmstaedt K, Gerstberger T, Eckert S, Hoffmann B, Hoppert M, Schnappauf G, Braus GH (1999) The aroC gene of Aspergillus nidulans codes for a monofunctional, allosterically regulated chorismate mutase. J Biol Chem 274: 22275-22282
25. Lee BS, Taylor JW (1990) Isolation of DNA from fungal mycelia and single spores. In: Innis MA, Gelfand DH, Sninsky JS, White TJ (eds) PCR protocols: a guide to methods and applications. Academic Press, San Diego, pp 282-287
26. Lu Y, Mach RL, Affenzeller K, Kubicek CP (1992) Regulation of alpha-aminoadipate reductase from Penicillium chrysogenum in relation to the flux from alpha-aminoadipate into penicillin biosynthesis. Can J Microbiol 38: 758-763
27. Luengo JM, Penalva MA (1994) Penicillin biosynthesis. In: Martinelli SD, Klinghorn JR (eds) Aspergillus: 50 years on. (Prog Ind Microbiol) Elsevier, Amsterdam, pp 603-638
28. MacCabe AP, Riach MB, Unkles SE, Kinghorn JR (1990) The Aspergillus nidulans npeA locus consists of three contiguous genes required for penicillin biosynthesis. EMBO J 9: 279-287
29. Martin JF (1998) New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis. Appl Microbiol Biotechnol 50: 1-15
30. Martin JF (2000) Molecular control of expression of penicillin biosynthesis genes in fungi: regulatory proteins interact with a bidirectional promoter region. J Bacteriol 182: 2355-2362
31. Mathieu M, Felenbok B (1994) The Aspergillus nidulans CREA protein mediates glucose repression of the ethanol regulon at various levels through competition with the ALCR-specific transactivator. EMBO J 13: 4022-4027
32. Mavrothalassitis G, Beal G, Papas TS (1990) Defining target sequences of DNA-binding proteins by random selection and PCR: determination of the GCN4-binding sequence repertoire. DNA Cell Biol 9: 783-788
33. Natarajan K, Meyer MR, Jackson BM, Slade D, Roberts C, Hinnebusch AG, Marton MJ (2001) Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol Cell Biol 21: 4347-4368
34. Ogawa H, Hase T, Fujioka M (1980) Amino acid sequence of a peptide containing an essential cysteine residue of yeast saccharopine dehydrogenase (L-lysine-forming). Biochim Biophys Acta 623: 225-228
35. Oliphant AR, Brandl CJ, Struhl K (1989) Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein. Mol Cell Biol 9: 2944-2949
36. Perez-Esteban B, Orejas M, Gomez-Pardo E, Penalva MA (1993) Molecular characterization of a fungal secondary metabolism promoter: transcription of the Aspergillus nidulans isopenicillin N synthetase gene is modulated by upstream negative elements. Mol Microbiol 9: 881-895
37. Punt PJ, Dingemanse MA, Jacobs-Meijsing BJ, Pouwels PH, Hondel CA van den (1988) Isolation and characterization of the glyceraldehyde-3-phosphate dehydrogenase gene of Aspergillus nidulans. Gene 69: 49-57
38. Ramon D, Carramolino L, Patino C, Sanchez F, Penalva MA (1987) Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the β-lactam ring in Aspergillus nidulans. Gene 57: 171-181
39. Sachs MS (1996) General and cross-pathway controls of amino acid biosynthesis. In: Brambl R, Marzluf GA (eds) The Mycota III. Biochemistry and molecular biology. Springer, Berlin Heidelberg New York, pp 315-345
40. Schenk WA (2000) Isopenicillin-N-Synthase: Ein Enzym bei der Arbeit. Angew Chemie 19: 3551-3554
41. Steidl S, Papagiannopoulos P, Litzka O, Andrianopoulos A, Davis MA, Brakhage AA, Hynes MJ (1999) AnCF, the CCAAT binding complex of Aspergillus nidulans, contains products of the hapB, hapC, and hapE genes and is required for activation by the pathway-specific regulatory gene amdR. Mol Cell Biol 19: 99-106
42. Strittmatter AW, Irniger S, Braus GH (2001) Induction of jlbA mRNA synthesis for a putative bZIP protein of Aspergillus nidulans by amino acid starvation. Curr Genet 39: 327-334
43. Then Bergh K, Brakhage AA (1998) Regulation of the Aspergillus nidulans penicillin biosynthesis gene acvA (pcbAB) by amino acids: implication for involvement of transcription factor PACC. Appl Environ Microbiol 64: 843-849
44. Valerius O, Draht O, Kübler E, Adler K, Hoffmann B, Braus GH (2001) Regulation of hisHF transcription of Aspergillus nidulans by adenine and amino acid limitation. Fungal Genet Biol 32: 21-31
45. Waring RB, May GS, Morris NR (1989) Characterization of an inducible expression system in Aspergillus nidulans using alcA and tubulin-coding genes. Gene 79: 119-130
46. Weidner G, Steffan B, Brakhage AA (1997) The Aspergillus nidulans lysF gene encodes homoaconitase, an enzyme involved in the fungus-specific lysine biosynthesis pathway. Mol Gen Genet 255: 237-247
47. Weidner G, Steidl S, Brakhage AA (2001) The Aspergillus nidulans homoaconitase gene lysF is negatively regulated by the multimeric CCAAT-binding complex AnCF and positively regulated by GATA sites. Arch Microbiol 175: 122-132
48. Whiteman PA, Abraham EP, Baldwin JE, Fleming MD, Schofield CJ, Sutherland JD, Willis AC (1990) Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans. FEBS Lett 262: 342-344
49. Xuan JW, Fournier P, Declerck N, Chasles M, Gaillardin C (1990) Overlapping reading frames at the LYS5 locus in the yeast Yarrowia lipolytica. Mol Cell Biol 10: 4795-4806
50. Zabriskie TM, Jackson MD (2000) Lysine biosynthesis and metabolism in fungi. Nat Prod Rep 17: 85-97