Nitrogen metabolite signalling involves the C-terminus the GATA domain of the Aspergillus transcription factor AREA and the 3′ untranslated region of its mRNA

EMBO Journal

Volumn 15, Issue 11, 1996, Pages 2791-2801

  Platt, Adam ^a,g   Langdon, Tim ^b,c   Arst Jr , Herbert N ^b   Kirk, Dennis ^g   Tollervey, David ^d,e   Sanchez, Jose M Mates ^b,f   Caddick, Mark X ^g  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c ABERYSTWYTH UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^f UNIVERSITY OF MÁLAGA   (Spain)

^g UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

AreA; Aspergillus nidulans; Nitiogen metabolism; RNA stability; Signal transduction

Indexed keywords

ASPERGILLUS; EMERICELLA NIDULANS;

DNA BINDING PROTEIN; MESSENGER RNA; MUTANT PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; ASPERGILLUS NIDULANS; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; METABOLIC INHIBITION; MOLECULAR STABILITY; NITROGEN METABOLISM; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RNA DEGRADATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION;

AMINO ACID SEQUENCE; ASPERGILLUS NIDULANS; BINDING SITES; DNA MUTATIONAL ANALYSIS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MOLECULAR SEQUENCE DATA; NITROGEN; PROMOTER REGIONS (GENETICS); RNA, FUNGAL; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0029950890     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00639.x     Document Type: Article

References (24)

1. Arceci,R.J., King,A.A.J., Simon,M.C., Orkin,S.H. and Wilson,D.B. (1993) Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol. Cell. Biol., 13, 2235-2246.
2. Arst,H.N.,Jr (1982) A near terminal pericentric inversion leads to nitrogen metabolite derepression in Aspergillus nidulans. Mol. Gen. Genet., 188, 490-493.
3. Arst,H.N.,Jr and Cove,D.J. (1973) Nitrogen metabolite repression in Aspergillus nidulans. Mol. Gen. Genet., 126, 111-141.
4. Arst,H.N.,Jr and Scazzocchio,C. (1975) Initiator constitutive mutation with an 'up-promoter' effect in Aspergillus nidulans. Nature, 254, 31-34.
5. Arst,H.N.,Jr, Penfold,H.A. and Bailey,C.R. (1978) Lactam utilization in Aspergillus nidulans: evidence for a fourth gene under the control of the integrator gene intA. Mol. Gen. Genet., 166, 312-317.
6. Arst,H.N.,Jr, Kudla,B., Martinez-Rossi,N., Caddick,M.X., Sibley,S. and Davies,R.W. (1989) Aspergillus and mouse share a new class of zinc finger protein. Trends Genet., 5, 291.
7. Shaffer,P.M. and Arst,H.N.Jr (1984) An asparaginase of Aspergillus nidulans is subject to oxygen repression in addition to nitrogen metabolite repression. Mol. Gen. Genet., 198, 139-145.
8. Shaffer,P.M., Arst,H.N.,Jr. Estberg,L., Fernando,L., Ly,T. and Sitter,M. (1988) Regulation of pyrimidine salvage in Aspergillus nidulans: a role for the major regulatory gene areA mediating nitrogen metabolite repression. Mol. Gen. Genet., 212, 337-341.
9. Sokolovsky,V., Kaldenhoff,R., Ricci,M. and Russo,V.E.A. (1990) Fast and reliable mini-prep RNA extraction from Neurospora crassa. Fungal Genetics Newsletter, 37, 41-12.
10. Stanbrough,M., Rowen,D.W. and Magasanik,B. (1995) Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. Proc. Natl Acad. Sci. USA, 92, 9450-9454.
11. Stankovich,M., Platt,A., Caddick,M.X., Langdon,T., Shaffer,P.M. and Arst.H.N.,Jr (1993) C-terminal truncation of the transcriptional activator encoded by areA in Aspergillus nidulans results in both loss-of-function and gain-of-function phenotypes. Mol. Microbiol., 7, 81-87.
12. Tilburn,J., Sarkar,S., Widdick,D.A., Espeso,E.A., Orejas,M., Mungroo,J., Penalva,M.A. and Arst,H.N.,Jr(1995) The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid-and alkaline-expressed genes by ambient pH. EMBO J., 14, 779-790.
13. Tollervey,D.W. (1981) Aspects of nitrogen metabolic regulation in Aspergillus nidulans. Ph.D. Thesis, University of Cambridge, Cambridge, UK.
14. Tsai,S.-F., Martin,D.I.K., Zon,L.I., D'Andrea,A.D., Wong,G.G. and Orkin,S.H. (1989) Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature, 399, 446-451.
15. Voisard,C., Wang,J., McEvoy,J.L., Xu,P. and Leong,S.A. (1993) Urbs1 a gene regulating siderophore biosynthesis in Ustilago maydis, encodes a protein similar to the erythroid specific transcription factor GATA-1. Mol. Cell. Biol., 13, 7091-7100.
16. Wiame,J.-M., Grenson,M. and Arst,H.N.,Jr (1985) Nitrogen catabolite repression in yeasts and filamentous fungi. Adv. Microb. Physiol., 26, 1-88.
17. Xiao,X., Fu,Y.-H. and Marzluf,G.A. (1995) The negative-acting NMR regulatory protein of Neurospora crassa binds to and inhibits the DNA-binding activity of the positive-acting nitrogen regulatory protein NIT2. Biochemistry, 34, 8861-8868.
18. Yamamoto,M., Ko,L.J., Leonard,M.W., Beug,H., Orkin,S.H. and Engel,J.D. (1990) Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev., 4, 1650-1662.
19. Yang,H.-Y. and Evans,T. (1992) Distinct roles for the two cGATA-1 finger domains. Mol. Cell. Biol., 12, 4562-4570.
20. Yang,H.-Y. and Evans,T. (1995) Homotypic interactions of chicken GATA-1 can mediate transcriptional activation. Mol. Cell. Biol., 15, 1353-1363.
21. Yang,Z., Gu,L., Romeo,P.H., Bories,D., Motohashi,H., Yamamoto,M. and Engel,J.D. (1994) Human GATA-3 transactivation, DNA binding and nuclear localization activities are organised into distinct structural domains. Mol. Cell. Biol., 14, 2201-2212.
22. Young,J.L. and Marzluf,G.A. (1991) Molecular comparison of the negative-acting nitrogen control gene, nmr, in Neurospora crassa and other Neurospora and fungal species. Biochem. Genet., 29, 447-459.
23. Young,J.L., Jarai,G., Fu,Y.-H. and Marzluf,G.A. (1990) Nucleotide sequence and analysis of NMR, a negative-acting regulatory gene of in the nitrogen circuit of Neurospora crassa. Mol. Gen. Genet., 222, 120-128.
24. Zon,L.I., Tsai,S.-F., Burgess,S., Matsudaira,P., Burns,G.A.P. and Orkin,S.H. (1990) The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome. Proc. Natl Acad. Sci. USA. 87, 668-672.