Dopamine acts as a partial agonist for α2A adrenoceptor in melanin-concentrating hormone neurons

Journal of Neuroscience

Volumn 31, Issue 29, 2011, Pages 10671-10676

  Alberto, Christian O ^a   Trask, Robert B ^a   Hirasawa, Michiru ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; BLR 44408; DOPAMINE; DOPAMINE BETA MONOOXYGENASE; FUSARIC ACID; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; LE 300; MELANIN CONCENTRATING HORMONE; NORADRENALIN; QUINPIROLE; SULPIRIDE; TERTIAPIN Q; TETRODOTOXIN; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CATECHOLAMINERGIC SYSTEM; CELLULAR PARAMETERS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; FEMALE; HYPERPOLARIZATION; MALE; NERVE CELL INHIBITION; NERVE CELL STIMULATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WHOLE CELL;

ACTION POTENTIALS; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; BEE VENOMS; CARBOLINES; DOPAMINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; HYPOTHALAMUS; MELANINS; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79960684570     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6245-10.2011     Document Type: Article

References (44)

1. Adamson TW, Corll C, Svec F, Porter J (2010) Role of the perifornical hypothalamic monoamine neurotransmitter systems in anorectic effects of endotoxin. Neuroendocrinology 91:48-55.
2. Aguayo LG, Grossie J (1994) Dopamine inhibits a sustained calcium current through activation of alpha adrenergic receptors and a GTP-binding protein in adult rat sympathetic neurons. J Pharmacol Exp Ther 269:503-508.
3. Alberto CO, Trask RB, Quinlan ME, Hirasawa M (2006) Bidirectional dopaminergic modulation of excitatory synaptic transmission in orexin neurons. J Neurosci 26:10043-10050.
4. Baldo BA, Daniel RA, Berridge CW, Kelley AE (2003) Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. J Comp Neurol 464:220-237.
5. Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, Vale W, Sawchenko PE (1992) The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 319:218-245.
6. Borowsky B, Durkin MM, Ogozalek K, Marzabadi MR, DeLeon J, Lagu B, Heurich R, Lichtblau H, Shaposhnik Z, Daniewska I, Blackburn TP, Branchek TA, Gerald C, Vaysse PJ, Forray C (2002) Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat Med 8:825-830.
7. Bubser M, Fadel JR, Jackson LL, Meador-Woodruff JH, Jing D, Deutch AY (2005) Dopaminergic regulation of orexin neurons. Eur J Neurosci 21:2993-3001.
8. Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O (2009) The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A 106:6772-6777.
9. Cornil CA, Ball GF (2008) Interplay among catecholamine systems: dopamine binds to alpha2-adrenergic receptors in birds and mammals. J Comp Neurol 511:610-627.
10. Cornil CA, Balthazart J, Motte P, Massotte L, Seutin V (2002) Dopamine activates noradrenergic receptors in the preoptic area. J Neurosci 22:9320-9330.
11. Ford CP, Phillips PE, Williams JT (2009) The time course of dopamine transmission in the ventral tegmental area. J Neurosci 29:13344-13352.
12. Gao XB, Ghosh PK, van den Pol AN (2003) Neurons synthesizing elaninconcentrating hormone identified by selective reporter gene expression after transfection in vitro: transmitter responses. J Neurophysiol 90:3978-3985.
13. Garris PA, Ciolkowski EL, Pastore P, Wightman RM (1994) Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain. J Neurosci 14:6084-6093.
14. Georgescu D, Sears RM, Hommel JD, Barrot M, Bolaños CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ, DiLeone RJ (2005) The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci 25:2933-2940.
15. Han P, Whelan PJ (2009) Modulation of AMPA currents by D1-like but not D2-like receptors in spinal motoneurons. Neuroscience 158:1699-1707.
16. Hidaka H (1971) Fusaric (5-butylpicolinic) acid, an inhibitor of dopamine beta-hydroxylase, affects serotonin and noradrenaline. Nature 231:54-55.
17. Itoi K, Sugimoto N (2010) The brainstem noradrenergic systems in stress, anxiety and depression. J Neuroendocrinol 22:355-361.
18. Kawagoe KT, Garris PA, Wiedemann DJ, Wightman RM (1992) Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum. Neuroscience 51:55-64.
19. Lähdesmäki J, Sallinen J, MacDonald E, Kobilka BK, Fagerholm V, Scheinin M (2002) Behavioral and neurochemical characterization of [alpha]2Aadrenergic receptor knockout mice. Neuroscience 113:289-299.
20. Leaney JL, Benians A, Brown S, Nobles M, Kelly D, Tinker A (2004) Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined byGprotein cycle. AmJ Physiol Cell Physiol 287:C182-C191.
21. Leibowitz SF, Brown LL (1980) Histochemical and pharmacological analysis of catecholaminergic projections to the perifornical hypothalamus in relation to feeding inhibition. Brain Res 201:315-345.
22. Leibowitz SF, Rossakis C (1978) Analysis of feeding suppression produced by perifornical hypothalamic injection of catecholamines, amphetamines and mazindol. Eur J Pharmacol 53:69-81.
23. Li Y, van den Pol AN (2005) Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons. J Neurosci 25:173-183.
24. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E (2001) Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest 107:379-386.
25. Margules DL (1970) Alpha-adrenergic receptors in hypothalamus for the suppression of feeding behavior by satiety. J Comp Physiol Psychol 73:1-12.
26. Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, Guan XM, Jiang MM, Feng Y, Camacho RE, Shen Z, Frazier EG, Yu H, Metzger JM, Kuca SJ, Shearman LP, Gopal-Truter S, MacNeil DJ, Strack AM, MacIntyre DE, et al (2002) Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci U S A 99:3240-3245.
27. Meguid MM, Yang ZJ, Koseki M (1995) Eating induced rise in LHAdopamine correlates with meal size in normal and bulbectomized rats. Brain Res Bull 36:487-490.
28. Modirrousta M, Mainville L, Jones BE (2005) Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur J Neurosci 21:2807-2816.
29. Myers RD, McCaleb ML (1980) Feeding: satiety signal from intestine triggers brain's noradrenergic mechanism. Science 209:1035-1037.
30. Nestler EJ, Carlezon WA Jr (2006) The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 59:1151-1159.
31. Nicholson C (1995) Interaction between diffusion and Michaelis-Menten uptake of dopamine after iontophoresis in striatum. Biophys J 68:1699-1715.
32. Nyrönen T, Pihlavisto M, Peltonen JM, Hoffrén AM, Varis M, Salminen T, Wurster S, Marjamäki A, Kanerva L, Katainen E, Laaksonen L, Savola JM, Scheinin M, Johnson MS (2001) Molecular mechanism for agonistpromoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine. Mol Pharmacol 59:1343-1354.
33. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, Maratos-Flier E (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380:243-247.
34. Ross SB (1991) Synaptic concentration of dopamine in the mouse striatum in relationship to the kinetic properties of the dopamine receptors and uptake mechanism. J Neurochem 56:22-29.
35. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585.
36. Saper CB, Scammell TE, Lu J (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257-1263.
37. Schramm NL, McDonald MP, Limbird LE (2001) The [alpha]2Aadrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. J Neurosci 21:4875- 4882.
38. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E (1998) Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396:670-674.
39. Sita LV, Elias CF, Bittencourt JC (2003) Dopamine and melanin-concentrating hormone neurons are distinct populations in the rat rostromedial zona incerta. Brain Res 970:232-237.
40. Smith DG, Tzavara ET, Shaw J, Luecke S, Wade M, Davis R, Salhoff C, Nomikos GG, Gehlert DR (2005) Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice. J Neurosci 25:914-922.
41. van den Pol AN, Acuna-Goycolea C, Clark KR, Ghosh PK (2004) Physiological properties of hypothalamicMCHneurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 42:635-652.
42. Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Léger L, Boissard R, Salin P, Peyron C, Luppi PH (2003) A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci 4:19.
43. Willie JT, Sinton CM, Maratos-Flier E, Yanagisawa M (2008) Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression. Neuroscience 156:819-829.
44. Zhang W, Klimek V, Farley JT, Zhu MY, Ordway GA (1999) Alpha2c adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine. J Pharmacol Exp Ther 289:1286-1292.