-
1
-
-
62849128369
-
Renal cell carcinoma
-
10.1016/S0140-6736(09)60229-4, 19269025
-
Rini BI, Campbell SC, Escudier B. Renal cell carcinoma. Lancet 2009, 373:1119-1132. 10.1016/S0140-6736(09)60229-4, 19269025.
-
(2009)
Lancet
, vol.373
, pp. 1119-1132
-
-
Rini, B.I.1
Campbell, S.C.2
Escudier, B.3
-
2
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
10.1038/nrc885, 12209156
-
Kaelin WG. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2002, 2:673-682. 10.1038/nrc885, 12209156.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 673-682
-
-
Kaelin, W.G.1
-
3
-
-
0027240519
-
Identification of the von Hippel-Lindau disease tumor suppressor gene
-
10.1126/science.8493574, 8493574
-
Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Hui Wei M, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan DR, Dean M, Glavačc D, Richards FM, Crossey PA, Ferguson-Smith MA, Le Paslier D, Chumakov I, Cohen D, Chinault AC, Maher ER, Linehan WM, et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993, 260:1317-1320. 10.1126/science.8493574, 8493574.
-
(1993)
Science
, vol.260
, pp. 1317-1320
-
-
Latif, F.1
Tory, K.2
Gnarra, J.3
Yao, M.4
Duh, F.M.5
Orcutt, M.L.6
Stackhouse, T.7
Kuzmin, I.8
Modi, W.9
Geil, L.10
Schmidt, L.11
Zhou, F.12
Li, H.13
Hui Wei, M.14
Chen, F.15
Glenn, G.16
Choyke, P.17
Walther, M.M.18
Weng, Y.19
Duan, D.R.20
Dean, M.21
Glavačc, D.22
Richards, F.M.23
Crossey, P.A.24
Ferguson-Smith, M.A.25
Le Paslier, D.26
Chumakov, I.27
Cohen, D.28
Chinault, A.C.29
Maher, E.R.30
Linehan, W.M.31
more..
-
4
-
-
66449114724
-
Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells
-
10.1016/j.advenzreg.2008.12.005, 19162062
-
Harten SK, Esteban MA, Maxwell PH. Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells. Adv Enzyme Regul 2009, 49:43-52. 10.1016/j.advenzreg.2008.12.005, 19162062.
-
(2009)
Adv Enzyme Regul
, vol.49
, pp. 43-52
-
-
Harten, S.K.1
Esteban, M.A.2
Maxwell, P.H.3
-
5
-
-
32944457801
-
Von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms
-
10.1158/0008-5472.CAN-05-3236, 16452212
-
Calzada MJ, Esteban MA, Feijoo-Cuaresma M, Castellanos MC, Naranjo-Suarez S, Temes E, Mendez F, Yanez-Mo M, Ohh M, Landazuri MO. von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms. Cancer Res 2006, 66:1553-1560. 10.1158/0008-5472.CAN-05-3236, 16452212.
-
(2006)
Cancer Res
, vol.66
, pp. 1553-1560
-
-
Calzada, M.J.1
Esteban, M.A.2
Feijoo-Cuaresma, M.3
Castellanos, M.C.4
Naranjo-Suarez, S.5
Temes, E.6
Mendez, F.7
Yanez-Mo, M.8
Ohh, M.9
Landazuri, M.O.10
-
6
-
-
64049084322
-
Regulation of renal epithelial tight junctions by the VHL tumor suppressor gene involves repression of occludin and claudin 1 and is independent of E-cadherin
-
Harten SK, Deepa S, Barod R, Hergovich A, Balda M, Matter K, Esteban MA, Maxwell PH. Regulation of renal epithelial tight junctions by the VHL tumor suppressor gene involves repression of occludin and claudin 1 and is independent of E-cadherin. Mol Biol Cell 2009, 20:13.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 13
-
-
Harten, S.K.1
Deepa, S.2
Barod, R.3
Hergovich, A.4
Balda, M.5
Matter, K.6
Esteban, M.A.7
Maxwell, P.H.8
-
7
-
-
33645748171
-
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
-
10.1158/0008-5472.CAN-05-2670, 16585181
-
Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, Raval R, O'Brien T S, Maxwell PH. Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res 2006, 66:3567-3575. 10.1158/0008-5472.CAN-05-2670, 16585181.
-
(2006)
Cancer Res
, vol.66
, pp. 3567-3575
-
-
Esteban, M.A.1
Tran, M.G.2
Harten, S.K.3
Hill, P.4
Castellanos, M.C.5
Chandra, A.6
Raval, R.7
O'Brien T, S.8
Maxwell, P.H.9
-
8
-
-
33645090169
-
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
-
10.1158/0008-5472.CAN-05-3719, 16510593
-
Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res 2006, 66:2725-2731. 10.1158/0008-5472.CAN-05-3719, 16510593.
-
(2006)
Cancer Res
, vol.66
, pp. 2725-2731
-
-
Krishnamachary, B.1
Zagzag, D.2
Nagasawa, H.3
Rainey, K.4
Okuyama, H.5
Baek, J.H.6
Semenza, G.L.7
-
9
-
-
33745819269
-
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
-
10.1681/ASN.2006020181, 16775032
-
Esteban MA, Harten SK, Tran MG, Maxwell PH. Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J Am Soc Nephrol 2006, 17:1801-1806. 10.1681/ASN.2006020181, 16775032.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1801-1806
-
-
Esteban, M.A.1
Harten, S.K.2
Tran, M.G.3
Maxwell, P.H.4
-
10
-
-
34247863920
-
PVHL and GSK3beta are components of a primary cilium-maintenance signalling network
-
10.1038/ncb1579, 17450132
-
Thoma CR, Frew IJ, Hoerner CR, Montani M, Moch H, Krek W. pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat Cell Biol 2007, 9:588-595. 10.1038/ncb1579, 17450132.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 588-595
-
-
Thoma, C.R.1
Frew, I.J.2
Hoerner, C.R.3
Montani, M.4
Moch, H.5
Krek, W.6
-
11
-
-
33746886185
-
Primary cilium formation requires von hippel-lindau gene function in renal-derived cells
-
10.1158/0008-5472.CAN-06-0501, 16849532
-
Lutz MS, Burk RD. Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res 2006, 66:6903-6907. 10.1158/0008-5472.CAN-06-0501, 16849532.
-
(2006)
Cancer Res
, vol.66
, pp. 6903-6907
-
-
Lutz, M.S.1
Burk, R.D.2
-
12
-
-
2642553111
-
Neuromedin U and its receptors: structure, function, and physiological roles
-
10.1124/pr.56.2.3, 15169928
-
Brighton PJ, Szekeres PG, Willars GB. Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 2004, 56:231-248. 10.1124/pr.56.2.3, 15169928.
-
(2004)
Pharmacol Rev
, vol.56
, pp. 231-248
-
-
Brighton, P.J.1
Szekeres, P.G.2
Willars, G.B.3
-
13
-
-
4444353425
-
Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias
-
10.1182/blood-2003-10-3577, 15187020
-
Shetzline SE, Rallapalli R, Dowd KJ, Zou S, Nakata Y, Swider CR, Kalota A, Choi JK, Gewirtz AM. Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. Blood 2004, 104:1833-1840. 10.1182/blood-2003-10-3577, 15187020.
-
(2004)
Blood
, vol.104
, pp. 1833-1840
-
-
Shetzline, S.E.1
Rallapalli, R.2
Dowd, K.J.3
Zou, S.4
Nakata, Y.5
Swider, C.R.6
Kalota, A.7
Choi, J.K.8
Gewirtz, A.M.9
-
14
-
-
61849136239
-
Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway
-
10.1016/j.canlet.2008.11.028, 19118941
-
Ketterer K, Kong B, Frank D, Giese NA, Bauer A, Hoheisel J, Korc M, Kleeff J, Michalski CW, Friess H. Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. Cancer Lett 2009, 277:72-81. 10.1016/j.canlet.2008.11.028, 19118941.
-
(2009)
Cancer Lett
, vol.277
, pp. 72-81
-
-
Ketterer, K.1
Kong, B.2
Frank, D.3
Giese, N.A.4
Bauer, A.5
Hoheisel, J.6
Korc, M.7
Kleeff, J.8
Michalski, C.W.9
Friess, H.10
-
15
-
-
7044229277
-
Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway
-
10.1038/nm1106, 15448684
-
Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M. Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 2004, 10:1067-1073. 10.1038/nm1106, 15448684.
-
(2004)
Nat Med
, vol.10
, pp. 1067-1073
-
-
Hanada, R.1
Teranishi, H.2
Pearson, J.T.3
Kurokawa, M.4
Hosoda, H.5
Fukushima, N.6
Fukue, Y.7
Serino, R.8
Fujihara, H.9
Ueta, Y.10
Ikawa, M.11
Okabe, M.12
Murakami, N.13
Shirai, M.14
Yoshimatsu, H.15
Kangawa, K.16
Kojima, M.17
-
16
-
-
0022249076
-
Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord
-
10.1016/0006-291X(85)91726-7, 3839674
-
Minamino N, Kangawa K, Matsuo H. Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem Biophys Res Commun 1985, 130:1078-1085. 10.1016/0006-291X(85)91726-7, 3839674.
-
(1985)
Biochem Biophys Res Commun
, vol.130
, pp. 1078-1085
-
-
Minamino, N.1
Kangawa, K.2
Matsuo, H.3
-
17
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
10.1038/20459, 10353251
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399:271-275. 10.1038/20459, 10353251.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
18
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625-634.
-
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
19
-
-
0029147430
-
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
-
10.1126/science.7660130, 7660130
-
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG. Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science 1995, 269:1444-1446. 10.1126/science.7660130, 7660130.
-
(1995)
Science
, vol.269
, pp. 1444-1446
-
-
Kibel, A.1
Iliopoulos, O.2
DeCaprio, J.A.3
Kaelin, W.G.4
-
20
-
-
0035336706
-
Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
-
10.1093/hmg/10.10.1019, 11331612
-
Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WG. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum Mol Genet 2001, 10:1019-1027. 10.1093/hmg/10.10.1019, 11331612.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1019-1027
-
-
Hoffman, M.A.1
Ohh, M.2
Yang, H.3
Klco, J.M.4
Ivan, M.5
Kaelin, W.G.6
-
21
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
360482, 1448077
-
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992, 12:5447-5454. 360482, 1448077.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
22
-
-
33846846542
-
Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia
-
10.1038/sj.onc.1209835, 16878152
-
Wu Y, McRoberts K, Berr SS, Frierson HF, Conaway M, Theodorescu D. Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. Oncogene 2007, 26:765-773. 10.1038/sj.onc.1209835, 16878152.
-
(2007)
Oncogene
, vol.26
, pp. 765-773
-
-
Wu, Y.1
McRoberts, K.2
Berr, S.S.3
Frierson, H.F.4
Conaway, M.5
Theodorescu, D.6
-
23
-
-
33750323311
-
The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer
-
10.1158/0008-5472.CAN-06-1349, 17018595
-
Takahashi K, Furukawa C, Takano A, Ishikawa N, Kato T, Hayama S, Suzuki C, Yasui W, Inai K, Sone S, Ito T, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y. The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer. Cancer Res 2006, 66:9408-9419. 10.1158/0008-5472.CAN-06-1349, 17018595.
-
(2006)
Cancer Res
, vol.66
, pp. 9408-9419
-
-
Takahashi, K.1
Furukawa, C.2
Takano, A.3
Ishikawa, N.4
Kato, T.5
Hayama, S.6
Suzuki, C.7
Yasui, W.8
Inai, K.9
Sone, S.10
Ito, T.11
Nishimura, H.12
Tsuchiya, E.13
Nakamura, Y.14
Daigo, Y.15
-
24
-
-
34548071005
-
Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma
-
10.1158/1078-0432.CCR-07-0143, 17699851
-
Gumz ML, Zou H, Kreinest PA, Childs AC, Belmonte LS, LeGrand SN, Wu KJ, Luxon BA, Sinha M, Parker AS, Sun LZ, Ahlquist DA, Wood CG, Copland JA. Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 2007, 13:4740-4749. 10.1158/1078-0432.CCR-07-0143, 17699851.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4740-4749
-
-
Gumz, M.L.1
Zou, H.2
Kreinest, P.A.3
Childs, A.C.4
Belmonte, L.S.5
LeGrand, S.N.6
Wu, K.J.7
Luxon, B.A.8
Sinha, M.9
Parker, A.S.10
Sun, L.Z.11
Ahlquist, D.A.12
Wood, C.G.13
Copland, J.A.14
-
25
-
-
66349100709
-
Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney
-
10.1158/0008-5472.CAN-09-0146, 2745239, 19470766
-
Beroukhim R, Brunet JP, Di Napoli A, Mertz KD, Seeley A, Pires MM, Linhart D, Worrell RA, Moch H, Rubin MA, Sellers WR, Meyerson M, Linehan WM, Kaelin WG, Signoretti S. Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res 2009, 69:4674-4681. 10.1158/0008-5472.CAN-09-0146, 2745239, 19470766.
-
(2009)
Cancer Res
, vol.69
, pp. 4674-4681
-
-
Beroukhim, R.1
Brunet, J.P.2
Di Napoli, A.3
Mertz, K.D.4
Seeley, A.5
Pires, M.M.6
Linhart, D.7
Worrell, R.A.8
Moch, H.9
Rubin, M.A.10
Sellers, W.R.11
Meyerson, M.12
Linehan, W.M.13
Kaelin, W.G.14
Signoretti, S.15
-
26
-
-
23844524767
-
Gene signatures of progression and metastasis in renal cell cancer
-
10.1158/1078-0432.CCR-04-2225, 16115910
-
Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C, Gu X, Joseph M, Pantuck AJ, Jonas D, Libermann TA. Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res 2005, 11:5730-5739. 10.1158/1078-0432.CCR-04-2225, 16115910.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5730-5739
-
-
Jones, J.1
Otu, H.2
Spentzos, D.3
Kolia, S.4
Inan, M.5
Beecken, W.D.6
Fellbaum, C.7
Gu, X.8
Joseph, M.9
Pantuck, A.J.10
Jonas, D.11
Libermann, T.A.12
-
27
-
-
38449111737
-
The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
-
Zia MK, Rmali KA, Watkins G, Mansel RE, Jiang WG. The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells. Int J Mol Med 2007, 20:605-611.
-
(2007)
Int J Mol Med
, vol.20
, pp. 605-611
-
-
Zia, M.K.1
Rmali, K.A.2
Watkins, G.3
Mansel, R.E.4
Jiang, W.G.5
-
28
-
-
15044363087
-
Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens
-
Euer NI, Kaul S, Deissler H, Mobus VJ, Zeillinger R, Weidle UH. Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens. Oncol Rep 2005, 13:375-387.
-
(2005)
Oncol Rep
, vol.13
, pp. 375-387
-
-
Euer, N.I.1
Kaul, S.2
Deissler, H.3
Mobus, V.J.4
Zeillinger, R.5
Weidle, U.H.6
|