A comprehensive in vitro and in vivo evaluation of thiolated matrix tablets as a gastroretentive delivery system

Drug Delivery

Volumn 18, Issue 6, 2011, Pages 405-414

  Senyigit, Zeynep Ay ^a   Vetter, Anja ^b   Guneri, Tamer ^a   Bernkop Schnürch, Andreas ^b  

^a EGE UNIVERSITY   (Turkey)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

chitosan TBA; Gastroretentive drug delivery systems; mucoadhesion; PAA Cys; riboflavin

Indexed keywords

AMIDINE; CHITOSAN; CHITOSAN 4 THIOBUTHYLAMIDINE; CYSTEINE; POLYACRYLIC ACID; RIBOFLAVIN; UNCLASSIFIED DRUG;

ARTICLE; COVALENT BOND; DRUG DELIVERY SYSTEM; DRUG RETENTION; IN VITRO STUDY; IN VIVO STUDY; MATRIX TABLET; MUCOADHESION; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET FORMULATION;

ACRYLIC RESINS; ADHESIVENESS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHITIN; CYSTEINE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; GASTRIC MUCINS; GASTRIC MUCOSA; GLYCOPROTEINS; MALE; PHARMACOKINETICS; RATS; RATS, WISTAR; RIBOFLAVIN; SULFHYDRYL COMPOUNDS; TABLETS;

EID: 79960677435     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2011.570806     Document Type: Article

References (33)

1. Andrews, G.P., Laverty, T.P., Jones, D.S. (2009). Mucoadhesive polymeric platforms for controlled drug delivery. Eur J Pharm Biopharm. 71:505-18.
2. Ay Senyigit, Z., Vetter, A., Guneri, T., Bernkop-Schnürch, A. (2010). Gastroretentive particles formulated with thiomers: development and in vitro evaluation. J Drug Target. 18:362-72.
3. Bardonnet, P.L., Faivre, V., Pugh, W.J., Piffaretti, J.C., Falson, F. (2006). Gastroretentive dosage forms: overview and special case of Helicobacter pylori. J Contr Rel. 111:1-18. (Pubitemid 43289989)
4. Bernkop-Schnürch, A. (2000). Mucoadhesive polymers. In: Dumitriu, S., ed. Polymeric biomaterials. New york: Marcel Dekker, 147-65.
5. Bernkop-Schnürch, A. (2005). Thiomers: a new generation of mucoadhesive polymers. Adv Drug Deliv Rev. 57:1569-82. (Pubitemid 41443470)
6. Bernkop-Schnürch, A., Hornof, M., Zoidl, T. (2003). Thiolated polymers- thiomers: synthesis and in vitro evaluation of chitosan- 2-iminothiolane conjugates. Int J Pharm. 260:229-37. (Pubitemid 36773920)
7. Bernkop-Schnürch, A., König, V., Leitner, V.M., Krauland, A.H., Brodnik, I. (2004). Preparation and characterisation of thiolated poly(methacrylic acid)-starch compositions. Eur J Pharm. Biopharm. 57:219-24. (Pubitemid 38283697)
8. Bernkop-Schnürch, A., Scholler, S., Biebel, R.G. (2000). Development of controlled drug release systems based on polymer-cysteine conjugates. J Contr Rel. 66:39-48. (Pubitemid 30116683)
9. Bernkop-Schnürch, A., Schwarz, V., Steininger, S. (1999). Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm Res. 16:876-81. (Pubitemid 29284199)
10. Bernkop-Schnürch, A., Steninger, S. (2000). Synthesis and characterization of mucoadhesive thiolated polymers. Int J Pharm. 194:239-47. (Pubitemid 30110686)
11. Bruschi, M.L., Jones, D.S., Panzeri, H., Gremio, M.P.D., Freitas, O., Lara, E.H.G. (2007). Semisolid systems containing propolis for the treatment of periodontal disease: in vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. J Pharm Sci. 96:2074-89. (Pubitemid 47280102)
12. Colombo, P., Bettini, R., Santi, P., Peppas, N.A. (2000). Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance. Pharm Sci Technolo Today. 3:198-204. (Pubitemid 30364933)
13. Ege, M.A., Karasulu, H.Y., Karasulu, E., Ertan, G. (2001). A computer program designed for in vitro dissolution kinetics, in vitro-in vivo kinetic correlations and routine application. 4th Central European Symposium on Pharmaceutical Technology, Vienna, Scientia Pharmaceutica 69:127-8.
14. Grabovac, V., Guggi, D., Bernkop-Schnürch, A. (2005). Comparison of the mucoadhesive properties of various polymers. Adv Drug Deliv Reviews. 57:1713-23. (Pubitemid 41443475)
15. Gröning, R., Cloer, C., Georgarakis, M., Müller, R.S. (2007). Compressed collagen sponges as gastroretentive dosage forms: in vitro and in vivo studies. Eur J Pharm Sci. 30:1-6. (Pubitemid 44908920)
16. Guggi, D., Krauland, A.H., Bernkop-Schnürch, A. (2003). Systemic peptide delivery via stomach: in vivo evaluation of an oral dosage form for salmon calcitonin. J Contr Rel. 92:125-35. (Pubitemid 37130127)
17. Guggi, D., Marschütz, M.K., Bernkop-Schnürch, A. (2004). Matrix tablets based on thiolated poly(acrylic acid): pH-dependent variation in disintegration and mucoadhesion. Int J Pharm. 274:97-105. (Pubitemid 38457010)
18. Imam, M.E., Bernkop-Schnürch, A. (2005). Controlled drug delivery systems based on thiolated chitosan microspheres. Drug Dev Ind Pharm. 31:557-65. (Pubitemid 41285734)
19. Jones, D.S., Bruschi, M.L., Freitas, O., Gremio, M.P.D., Lara, E.H.G., Andrews, G.P. (2009). Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity. Int J Pharm. 372:49-58.
20. Jones, D.S., Woolfson, A.D., Brown, A.F., Coulter, W.A., McClelland, C., Irwin, C.R. (2000). Design, characterization and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J Contr Rel. 67:357-68. (Pubitemid 30303848)
21. Kagan, L., Lapidot, N., Afargan, M., Kirmayer, D., Moor, E., Mardor, Y., Friedman, M., Hoffman, A. (2006). Gastroretentive accordion pill: enhancement of riboflavin bioavailability in humans. J Contr Rel. 113:208-15. (Pubitemid 43963188)
22. Kast, C.A., Bernkop-Schnürch, A. (2001). Thiolated polymers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates. Biomaterials. 22:2345-52. (Pubitemid 32666227)
23. Klausner, E.A., Lavy, E., Stepensky, D., Friedman, M., Hoffman, A. (2002). Novel gastroretentive dosage forms: evaluation of gastroretentivity and its effect on riboflavin absorption in dogs. Pharm Res. 19:1516-23. (Pubitemid 35266557)
24. Lee, P.I., Peppas, N.A. (1987). Prediction of polymer dissolution in swellable controlled-release systems. J Contr Rel. 6:207-15. (Pubitemid 18017735)
25. Leitner, V.M., Marschütz, M.K., Bernkop-Schnürch, A. (2003a). Mucoadhesive and cohesive properties of poly(acrylic acid)- cysteine conjugates with regard to their molecular mass. Eur J Pharm Sci. 18:89-96. (Pubitemid 36120559)
26. Leitner, V.M., Walker, G.F., Bernkop-Schnürch, A. (2003b). Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins. Eur J Pharm Biopharm. 56:207-14. (Pubitemid 37072104)
27. Marschütz, M.K., Bernkop-Schnürch, A. (2002). Thiolated polymers: self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. Eur J Pharm Sci. 15:387-94. (Pubitemid 34436926)
28. Neves, J., Amaral, M.H., Bahia, M.F. (2008). Performance of an in vitro mucoadhesion testing method for vaginal semisolids: influence of different testing conditions and instrumental parameters. Eur J Pharm Biopharm. 69:622-32.
29. Peppas, N.A. (1985). Analysis of fickian and non-fickian drug release polymers. Pharm Acta Helv. 60:110-1.
30. Rinaudo, M. (2006). Chitin and chitosan: properties and applications. Prog Polym Sci. 31:603-32. (Pubitemid 44287019)
31. Ritger, P.L., Peppas, N.A. (1987). A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Contr Rel. 5:37-42. (Pubitemid 17106644)
32. Roldo, M., Hornof, M., Caliceti, P., Bernkop-Schnürch, A. (2004). Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vivo evaluation. Eur J Pharm Biopharm. 57:115-21. (Pubitemid 38058810)
33. Talukder, R., Fassihi, R. (2004). Gastroretentive delivery systems: a mini review. Drug Dev Ind Pharm. 30:1019-28. USP XXX-NF XXV. (2007). United States Pharmacopeial Convention Inc. 12601 Twinbrook Parkway, Rockville, MD 20852. (Pubitemid 39577994)