Development of controlled drug release systems based on thiolated polymers

Journal of Controlled Release

Volumn 66, Issue 1, 2000, Pages 39-48

  Bernkop Schnürch, Andreas ^a   Scholler, Sabine ^a   Biebel, Regina G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Carboxymethylcellulose cysteine conjugate; Controlled drug release; Mucoadhesion; Polycarbophil cysteine conjugate; Thiomers

Indexed keywords

CARBOXYMETHYLCELLULOSE; POLYCARBOPHIL; POLYMER; THIOL GROUP;

ARTICLE; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG STABILITY; MATRIX TABLET; PRIORITY JOURNAL; TABLET DISINTEGRATION; TABLET MANUFACTURE;

ACRYLIC RESINS; ADHESIVES; ADSORPTION; CARBOXYMETHYLCELLULOSE; CYSTEINE; DELAYED-ACTION PREPARATIONS; DISULFIDES; DRUG CARRIERS; FREEZE DRYING; HYDROGEN-ION CONCENTRATION; MUCOUS MEMBRANE; PHARMACEUTIC AIDS; POLYMERS; RIFAMPIN; SOLUBILITY; SULFHYDRYL COMPOUNDS; TABLETS, ENTERIC-COATED; WATER;

EID: 0034600188     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00256-4     Document Type: Article

References (17)

1. Ch'ng H.S., Park H., Kelly P., Robinson J.R. Bioadhesive polymers as platforms for oral controlled drug delivery II: synthesis and evaluation of some swelling water-insoluble bioadhesive polymers. J. Pharm. Sci. 74:1985;399-405.
2. Smart J.D., Kellaway I.W., Worthington H.E.C. An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol. 36:1984;295-299.
3. Duchêne D., Touchard F., Peppas N.A. Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev. Ind. Pharm. 14:1988;283-318.
4. Khosla R., Davis S.S. The effect of polycarbophil on the gastric emptying of pellets. J. Pharm. Pharmacol. 39:1987;47-49.
5. Lehr C.-M. Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract. Crit. Rev. Ther. Drug. 11:1994;119-160.
6. Irache J.M., Durrer C., Duchêne D., Ponchel G. Bioadhesion of lectin-latex conjugates to rat intestinal mucosa. Pharm. Res. 13:1996;1716-1719.
7. Bernkop-Schnürch A., Schwarz V., Steininger S. Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm. Res. 16:1999;876-881.
8. Gum J.R. Jr., Hicks J.W., Toribara N.W., Rothe E.-M., Lagace R.E., Kim Y.S. The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region. J. Biol. Chem. 267:1992;21375-21383.
9. Bernkop-Schnürch A., Göckel N.C. Development and analysis of a polymer protecting from luminal enzymatic degradation caused by α-chymotrypsin. Drug Dev. Ind. Pharm. 23:1997;733-740.
10. Roth H.J., Eger K., Troschütz R. 3rd Edition In Pharmazeutische Chemie II: Arzneistoffanalyse. 1990;188-192 Thieme Verlag, Stuttgart.
11. A. Bernkop-Schnürch, B. Gilge, Anionic mucoadhesive polymers as auxiliary agents for the peroral administration of (poly)peptide drugs: influence of the gastric fluid, Drug Dev. Ind. Pharm. (1999) in press.
12. Kaiho F., Lueßen H.L., Lehr C.-M., Verhoef J.C., Junginger H.E. Disintegration and gel forming behaviour of carbomer and its sodium salt used as excipients for direct compression. S.T.P. Pharma Sci. 6:1996;385-389.
13. Woodley J.F. Enzymatic barriers for GI peptide and protein delivery. Crit. Rev. Ther. Drug. 11:1994;61-95.
14. Bernkop-Schnürch A. The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J. Control. Release. 52:1998;1-16.
15. Bernkop-Schnürch A. Polymer-inhibitor conjugates: a promising strategy to overcome the enzymatic barrier to perorally administered (poly)peptide drugs? S.T.P. Pharma Sci. 9:1999;78-87.
16. Coupe A.J., Davis S.S., Wilding I.R. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm. Res. 8:1991;360-365.
17. Clausen A., Marschütz M., Riegler M., Bernkop-Schnürch A. Thiolated polycarbophil as penetration enhancer for (poly)peptide drugs. Proc. Int. Symp. Control. Release Bioact. Mater. 26:1999;369-370.