In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Hwang, Jimee ^a,b   Alemayehu, Bereket H ^c   Hoos, David ^d   Melaku, Zenebe ^c   Tekleyohannes, Samuel G ^c   Teshi, Takele ^c   Birhanu, Sintayehu G ^c   Demeke, Leykun ^c   Gobena, Kedir ^e   Kassa, Moges ^f   Jima, Daddi ^g   Reithinger, Richard ^h   Nettey, Henry ^a   Green, Michael ^a   Malone, Joseph L ^a   Kachur, S Patrick ^a   Filler, Scott ⁱ  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c International Center for AIDS Care and Treatment Programs   (Ethiopia)

^d International Center for AIDS Care and Treatment Programs   (United States)

^e Oromia Regional Health Bureau   (Ethiopia)

^f ETHIOPIAN PUBLIC HEALTH INSTITUTE   (Ethiopia)

^g FEDERAL MINISTRY OF HEALTH   (Ethiopia)

^h US Agency for International Development   (Ethiopia)

ⁱ TUBERCULOSIS AND MALARIA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; PROTOZOAL DNA;

ADOLESCENT; ADULT; ARTICLE; CHILD; COUGHING; DRUG EFFICACY; ETHIOPIA; FEMALE; FOLLOW UP; GENOTYPE; HUMAN; IN VIVO STUDY; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NAUSEA AND VOMITING; OPEN STUDY; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM VIVAX MALARIA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; SCHOOL CHILD; SURVIVAL; CLINICAL TRIAL; DRUG COMBINATION; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; TREATMENT OUTCOME;

ADOLESCENT; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DNA, PROTOZOAN; DRUG COMBINATIONS; ETHANOLAMINES; ETHIOPIA; FEMALE; FLUORENES; HUMANS; MALARIA, FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79960653268     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-209     Document Type: Article

References (52)

1. WHO, World Malaria Report 2009 Geneva: World Health Organization 2009
2. Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia. Barnes KI, Chanda P, Ab Barnabas G, Malar J 2009 8 Suppl 1 8 10.1186/1475-2875-8-S1-S8 19917078
3. Methods for surveillance of antimalarial drug efficacy. WHO, Geneva: World Health Organization 2009
4. Ethiopia Federal Ministry of Health, Health and Health Related Indicators report EC 2000 Addis Ababa: Ethiopia Federal Ministry of Health 2008
5. Plasmodium vivax and P. falciparum epidemiology in Gambella, south-west Ethiopia. Nigatu W, Abebe M, Dejene A, Trop Med Parasitol 1992 43 181 185 1470839
6. Change in epidemiology of malaria infections in a rural area in Ethiopia. Ramos JM, Reyes F, Tesfamariam A, J Travel Med 2005 12 155 156 15996444 (Pubitemid 40868368)
7. Chloroquine resistance of Plasmodium falciparum malaria in Ethiopia and Eritrea. Alene GD, Bennett S, Trop Med Int Health 1996 1 810 815 8980594 (Pubitemid 27010562)
8. An in-vivo study of falciparum malaria sensitivity to chloroquine in unstable malaria endemic area of central Ethiopia. Kebede F, Taffa N, Tedla T, Ethiopian Medical Journal 1999 37 97 109 11957310
9. Failure of chloroquine treatment for malaria in the highlands of Ethiopia. Tulu AN, Webber RH, Schellenberg JA, Bradley DJ, Trans R Soc Trop Med Hyg 1996 90 556 557 10.1016/S0035-9203(96)90322-3 8944273 (Pubitemid 26356642)
10. Efficacy of sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Ethiopia. Jima D, Tesfaye G, Medhin A, Kebede A, Argaw D, Babaniyi O, East African Med J 2005 82 391 395 (Pubitemid 41539863)
11. Death rates from malaria epidemics, Burundi and Ethiopia. Guthmann JP, Bonnet M, Ahoua L, Dantoine F, Balkan S, van Herp M, Tamrat A, Legros D, Brown V, Checchi F, Emerg Infect Dis 2007 13 140 143 10.3201/eid1301.060546 17370530 (Pubitemid 46057852)
12. Development of resistance by Plasmodium falciparum to sulfadoxine/pyrimethamine in Amhara Region, Northwestern Ethiopia. Kassa M, Sileshi M, Mohammed H, Taye G, Asfaw M, Ethiopian Medical Journal 2005 43 181 187 16370550 (Pubitemid 44763574)
13. Safety and efficacy of artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in Ethiopia. Jima D, Tesfaye G, Medhin A, Kebede A, Argaw D, Babaniyi O, East African Med J 2005 82 387 390 (Pubitemid 41539862)
14. A study on efficacy of Coartem in the treatment of uncomplicated Plasmodium falciparum malaria in Shele, Arbaminch Zuria Wereda, South West Ethiopia. Kassa M, Addis Ababa: Ethiopian Health and Nutrition Research Institute 2010
15. Therapeutic efficacy of artemether/lumefantrine (Coartem) against Plasmodium falciparum in Kersa, South West Ethiopia. Assefa A, Kassa M, Tadese G, Mohamed H, Animut A, Mengesha T, Parasit Vectors 2010 3 1 10.1186/1756-3305-3-1 20051120
16. Safety profile of Coartem: the evidence base. Falade C, Manyando C, Malar J 2009 8 Suppl 1 6 10.1186/1475-2875-8-S1-S6 19917076
17. The clinical efficacy of artemether/lumefantrine (Coartem). Makanga M, Krudsood S, Malar J 2009 8 Suppl 1 5 10.1186/1475-2875-8-S1-S5 19917075
18. WHO, Guidelines for the treatment of malaria. Second edition Geneva: World Health Organization 2010
19. Artemisinin resistance in Plasmodium falciparum malaria. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NP, Lindegardh N, Socheat D, White NJ, NEJM 2009 361 455 467 10.1056/NEJMoa0808859 19641202
20. Evidence of artemisinin-resistant malaria in western Cambodia. Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM, NEJM 2008 359 2619 2620 10.1056/NEJMc0805011 19064625
21. Malaria indicator survey 2007, Ethiopia: coverage and use of major malaria prevention and control interventions. Jima D, Getachew A, Bilak H, Steketee RW, Emerson PM, Graves PM, Gebre T, Reithinger R, Hwang J, Malar J 2010 9 58 10.1186/1475-2875-9-S2-P58 20178654
22. Malaria prevalence and mosquito net coverage in Oromia and SNNPR regions of Ethiopia. Shargie EB, Gebre T, Ngondi J, Graves PM, Mosher AW, Emerson PM, Ejigsemahu Y, Endeshaw T, Olana D, WeldeMeskel A, Teferra A, Tadesse Z, Tilahun A, Yohannes G, Richards FO, BMC Public Health 2008 8 321 10.1186/1471-2458-8-321 18803880
23. School-based surveys of malaria in Oromia Regional State, Ethiopia: a rapid survey method for malaria in low transmission settings. Ashton RA, Kefyalew T, Tesfaye G, Pullan RL, Yadeta D, Reithinger R, Kolaczinski JH, Brooker S, Malar J 2011 10 25 10.1186/1475-2875-10-25 21288368
24. Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. WHO, Geneva: World Health Organization 2003
25. Malaria: diagnosis and treatment guidelines for health workers in Ethiopia 2nd Edition. Ethiopia Federal Ministry of Health, Addis Ababa: Federal Democratic Republic of Ethiopia, Ministry of Health 2004
26. Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria. Ashley EA, Stepniewska K, Lindegardh N, McGready R, Annerberg A, Hutagalung R, Singtoroj T, Hla G, Brockman A, Proux S, Wilahphaingern J, Singhasivanon P, White NJ, Nosten F, Trop Med Int Health 2007 12 201 208 10.1111/j.1365-3156.2006.01785.x 17300626
27. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria. Ezzet F, van Vugt M, Nosten F, Looareesuwan S, White NJ, Antimicrob Agents Chemother 2000 44 697 704 10.1128/AAC.44.3.697-704.2000 10681341 (Pubitemid 30117964)
28. Handbook IMCI Integrated management of childhood illness. WHO, Geneva: World Health Organization 2006
29. Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in Thailand. Snounou G, Zhu X, Siripoon N, Jarra W, Thaithong S, Brown KN, Viriyakosol S, Trans R Soc Trop Med Hyg 1999 93 369 374 10.1016/S0035-9203(99)90120-7 10674079 (Pubitemid 29405860)
30. Development and validation of an automated solid-phase extraction and liquid chromatographic method for determination of lumefantrine in capillary blood on sampling paper. Blessborn D, Romsing S, Annerberg A, Sundquist D, Bjorkman A, Lindegardh N, Bergqvist Y, J Pharm Biomed Anal 2007 45 282 287 10.1016/j.jpba.2007.07.015 17719735
31. In vivo parasitological measures of artemisinin susceptibility. Stepniewska K, Ashley E, Lee SJ, Anstey N, Barnes KI, Binh TQ, D'Alessandro U, Day NP, de Vries PJ, Dorsey G, Guthmann JP, Mayxay M, Newton PN, Olliaro P, Osorio L, Price RN, Rowland M, Smithuis F, Taylor WR, Nosten F, White NJ, J Infect Dis 2010 201 570 579 10.1086/650301 20085495
32. An integrated assessment of the clinical safety of artemether- lumefantrine: a new oral fixed-dose combination antimalarial drug. Bakshi R, Hermeling-Fritz I, Gathmann I, Alteri E, Trans R Soc Trop Med Hyg 2000 94 419 424 10.1016/S0035-9203(00)90126-3 11127248 (Pubitemid 30662353)
33. Efficacy and safety of artemether-lumefantrine (Coartem) tablets (six-dose regimen) in African infants and children with acute, uncomplicated falciparum malaria. Falade C, Makanga M, Premji Z, Ortmann CE, Stockmeyer M, de Palacios PI, Trans R Soc Trop Med Hyg 2005 99 459 467 10.1016/j.trstmh.2004.09. 013 15837358 (Pubitemid 40521344)
34. A randomized trial of artesunate mefloquine versus artemether lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Senegalese children. Faye B, Ndiaye JL, Tine R, Sylla K, Gueye A, Lo AC, Gaye O, Am J Trop Med Hyg 2010 82 140 144 10.4269/ajtmh.2010.09-0265 20065010
35. Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus) versus artemether-lumefantrine (Coartem) against uncomplicated Plasmodium falciparum malaria: multisite trial in Senegal and Ivory Coast. Faye B, Offianan AT, Ndiaye JL, Tine RC, Toure W, Djoman K, Sylla K, Ndiaye PS, Penali L, Gaye O, Trop Med Int Health 2010 15 608 613 20214761
36. Efficacy and safety of the six-dose regimen of artemether-lumefantrine in pediatrics with uncomplicated Plasmodium falciparum malaria: a pooled analysis of individual patient data. Makanga M, Premji Z, Falade C, Karbwang J, Mueller EA, Andriano K, Hunt P, De Palacios PI, Am J Trop Med Hyg 2006 74 991 998 16760509 (Pubitemid 351627405)
37. Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. Dorsey G, Staedke S, Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR, Rosenthal PJ, JAMA 2007 297 2210 2219 10.1001/jama.297.20.2210 17519410
38. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G, Clin Infect Dis 2009 49 1629 1637 10.1086/647946 19877969
39. Safety and efficacy of lumefantrine-artemether (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Zambian adults. Mulenga M, VangGeertruyden JP, Mwananyanda L, Chalwe V, Moerman F, Chilengi R, Van Overmeir C, Dujardin JC, D'Alessandro U, Malar J 2006 5 73 10.1186/1475-2875-5-73 16923176 (Pubitemid 44481293)
40. Efficacy and safety of a fixed dose artesunate-sulphamethoxypyrazine- pyrimethamine compared to artemether-lumefantrine for the treatment of uncomplicated falciparum malaria across Africa: a randomized multi-centre trial. Sagara I, Rulisa S, Mbacham W, Adam I, Sissoko K, Maiga H, Traore OB, Dara N, Dicko YT, Dicko A, Jansen FH, Doumbo OK, Malar J 2009 8 63 10.1186/1475-2875-8- 63 19366448
41. Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison. Ratcliff A, Siswantoro H, Kenangalem E, Maristela R, Wuwung RM, Laihad F, Ebsworth EP, Anstey NM, Tjitra E, Price RN, Lancet 2007 369 757 765 10.1016/S0140-6736(07)60160-3 17336652 (Pubitemid 46335820)
42. Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria. Sowunmi A, Gbotosho GO, Happi CT, Adedeji AA, Fehintola FA, Folarin OA, Tambo E, Fateye BA, Am J Trop Med Hyg 2007 77 235 241 17690392 (Pubitemid 351859269)
43. Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial. Tshefu AK, Gaye O, Kayentao K, Thompson R, Bhatt KM, Sesay SS, Bustos DG, Tjitra E, Bedu-Addo G, Borghini-Fuhrer I, Duparc S, Shin CS, Fleckenstein L, Lancet 375 1457 1467
44. Simplified antimalarial therapeutic monitoring: using the day-7 drug level? White NJ, Stepniewska K, Barnes K, Price RN, Simpson J, Trends Parasitol 2008 24 159 163 10.1016/j.pt.2008.01.006 18353727
45. Population pharmacokinetics and therapeutic response of CGP 56697 (artemether + benflumetol) in malaria patients. Ezzet F, Mull R, Karbwang J, Br J Clin Pharmacol 1998 46 553 561 9862244 (Pubitemid 28522119)
46. The relationship between capillary and venous concentrations of the antimalarial drug lumefantrine (benflumetol). van Vugt M, Ezzet F, Phaipun L, Nosten F, White NJ, Trans R Soc Trop Med Hyg 1998 92 564 565 10.1016/S0035-9203(98)90917-8 9861382 (Pubitemid 28486492)
47. Randomized, controlled dose-optimization studies of dihydroartemisinin- piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand. Ashley EA, Krudsood S, Phaiphun L, Srivilairit S, McGready R, Leowattana W, Hutagalung R, Wilairatana P, Brockman A, Looareesuwan S, Nosten F, White NJ, J Infect Dis 2004 190 1773 1782 10.1086/425015 15499533 (Pubitemid 39487822)
48. High rate of Plasmodium vivax relapse following treatment of falciparum malaria in Thailand. Looareesuwan S, White NJ, Chittamas S, Bunnag D, Harinasuta T, Lancet 1987 2 1052 1055 2889965
49. A trial of combination antimalarial therapies in children from Papua New Guinea. Karunajeewa HA, Mueller I, Senn M, Lin E, Law I, Gomorrai PS, Oa O, Griffin S, Kotab K, Suano P, Tarongka N, Ura A, Lautu D, Page-Sharp M, Wong R, Salman S, Siba P, Ilett KF, Davis TM, NEJM 2008 359 2545 2557 10.1056/NEJMoa0804915 19064624
50. Artemisinin combination therapy for vivax malaria. Douglas NM, Anstey NM, Angus BJ, Nosten F, Price RN, Lancet Infect Dis 2010 10 405 416 10.1016/S1473-3099(10)70079-7 20510281
51. Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand. Tarning J, Ashley EA, Lindegardh N, Stepniewska K, Phaiphun L, Day NP, McGready R, Ashton M, Nosten F, White NJ, Antimicrob Agents Chemother 2008 52 1052 1061 10.1128/AAC.00955-07 18180343 (Pubitemid 351358388)
52. Ethiopia Federal Ministry of Health, Ethiopia National Malaria Indicator Survey 2007 Addis Ababa: Federal Ministry of Health, Ethiopia 2008