The relationship between capillary and venous concentrations of the antimalarial drug lumefantrine (benflumetol)

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 92, Issue 5, 1998, Pages 564-565

  Van Vugt, M ^a,b,c   Ezzet, F ^d   Phaipun, L ^a   Nosten, F ^a,b,e   White, N J ^b,e  

^a SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d NOVARTIS PHARMA AG   (Switzerland)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Artemether; Benflumetol; Blood concentrations; CGP 56697; Chemotherapy; Lumefantrine; Malaria; Plasmodium falciparum

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; BENFLUMETOL; BENFLUTEMOL; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CAPILLARY BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; FAT INTAKE; HUMAN; LIPOPHILICITY; MALARIA; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; VENOUS BLOOD;

PLASMODIUM FALCIPARUM;

EID: 0031764316     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(98)90917-8     Document Type: Article

References (5)

1. Ezzet, F. (1997). Pharmacokinetics of benflumetol; prevention of recrudescence following administration of co-artemether to malaria patients. Proceedings of conference on European co-operation in the field of scientific and technical research, 12-14 February 1997, Geneva. Brussels: European Commission, pp. 319-323.
2. Van Vugt, M., Brockman, A., Gemperli, B., Luxemburger, C., Gathman, I., Royce, C., Thra Slight, Looareesuwan, S., White, N. J. & Nosten, F. (1998). A randomized comparison of artemether-benflumetol and artesunate-mefloquine in the treatment of multi-drug resistant falciparum malaria. Antimicrobial Agents and Chemotherapy, 42, 135-139.
3. White, N. J. (1997). Assessment of the pharmacodynamic properties of antimalarial drugs in-vivo. Antimicrobial Agents and Chemotherapy, 41, 1413-1422.
4. WHO (1990). Severe and complicated malaria, 2nd edition. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, supplement 2.
5. Zeng, M. Y, Lu, Z. L., Yang, S. C., Zhang, M., Liao, J., Liu, S. L. & Teng, X. H. (1996). Determination of benflumetol in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. Journal of Chromatography, 681, 299-306.