Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus®) versus artemether-lumefantrine (Coartem®) against uncomplicated Plasmodium falciparum malaria: Multisite trial in Senegal and Ivory Coast

Tropical Medicine and International Health

Volumn 15, Issue 5, 2010, Pages 608-613

  Faye, Babacar ^a   Offianan, André Touré ^b   Ndiaye, Jean Louis ^a   Tine, Roger Clement ^a   Touré, Walatchin ^c   Djoman, Kali ^c   Sylla, Khadime ^a   Ndiaye, Paulette Suzanne ^a   Penali, Louis ^b   Gaye, Oumar ^a  

^a UNIVERSITÉ CHEIKH ANTA DIOP   (Senegal)

^b Institut Pasteur de Côte d'Ivoire   (France)

^c Formation Sanitaire Urbaine Communautaire FSU Com d'Anonkoua Kouté   (Côte d’Ivoire)

Author keywords

Artemether lumefantrine; Artesunate Amodiaquine; Plasmodium falciparum malaria; Randomised Phase IV trial; Senegal

Indexed keywords

AMODIAQUINE; AMODIAQUINE PLUS ARTESUNATE; ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; CAMOQUIN PLUS; UNCLASSIFIED DRUG;

DISEASE TREATMENT; DRUG; MALARIA; MEDICINE;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ANEMIA; ARTICLE; ASTHENIA; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COTE D'IVOIRE; DIZZINESS; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FEVER; GAMETOCYTE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MULTICENTER STUDY; NAUSEA AND VOMITING; NONHUMAN; PARASITOLOGY; PHASE 4 CLINICAL TRIAL; PLASMODIUM FALCIPARUM; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SENEGAL; SINGLE DRUG DOSE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AMODIAQUINE; ANTIMALARIALS; ARTEMISININS; CHILD; COTE D'IVOIRE; DRUG COMBINATIONS; ETHANOLAMINES; FEMALE; FLUORENES; HUMANS; MALARIA, FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; SENEGAL; STATISTICS AS TOPIC; YOUNG ADULT;

COTE D'IVOIRE; SENEGAL;

ARTESUNATE; PLASMODIUM FALCIPARUM;

EID: 77950637078     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2010.02487.x     Document Type: Article

References (14)

1. Adjei GO, Kurtzhals JAL, Rodrigues OP et al. (2008) Amodiaquine- artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up. Malaria Journal 7, 127.
2. Brasseur P, Agnamey P, Gaye O, Vaillant M, Taylor WRJ Olliaro PL (2007) Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal. Malaria Journal 6, 150. (Pubitemid 351143782)
3. Falade CO, Ogundele AO, Yusuf BO, Ademowo OG Ladipo SM (2008) High efficacy of two artemisinin-based combinations (artemether-lumefantrine and artesunate plus amodiaquine) for acute uncomplicated malaria in Ibadan, Nigeria. Tropical Medicine and International Health 13, 635 643.
4. Faye B, Ndiaye JL, Ndiaye D, Dieng Y, Faye O Gaye O (2007) Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal. Malaria Journal 6, 80. (Pubitemid 47064368)
5. Juma ElA, Obonyo O, Akhwale WS Ogutu BR (2008) A randomized, open-label, comparative efficacy trial of artemether-lumefantrine suspension versus artemether-lumefantrine tablets for treatment of uncomplicated Plasmodium falciparum malaria in children in western Kenya. Malaria Journal 7, 262.
6. Kobbe R, Klein P, Adjei S et al. (2008) A randomized trial on effectiveness of artemether lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children. Malaria Journal 7, 261.
7. Martin M, Alaribe A, Ejemot R et al. (2006) Artemether-Lumefantrine versus Artesunate plus Amodiaquine for treating uncomplicated childhood malaria in Nigeria: randomized controlled trial. Malaria Journal 5, 43. (Pubitemid 43865102)
8. Ménard D, Ratsimbasoa A, Randrianarivelojosia M et al. (2008) Assessment of the efficacy of antimalarial drugs recommended by the National Malaria Control Programme in Madagascar: Up-dated baseline data from randomized and multi-site clinical trial. Malaria Journa, 7, 55. (Pubitemid 351548816)
9. Ndayiragije A, Niyungeko D, Karenzo J et al. (2004) Efficacy of therapeutic combinations with artemisinin derivatives in the treatment of non complicated malaria in Burundi. Tropical Medicine and Hygiene 9, 673 679.
10. Ndiaye JLA, Faye B, Diouf A et al. (2008) Randomized, comparative study of the efficacy and safety of artesunate plus amodiaquine, administered as a single daily intake versus two daily intakes in the treatment of uncomplicated P. falciparum malaria. Malaria Journal 7, 16. (Pubitemid 351328665)
11. Oyakhirome S, Pötschke M, Schwarz NG et al. (2007) Artesunate - amodiaquine combination therapy for falciparum malaria in young Gabonese children. Malaria Journal 6, 29. (Pubitemid 46474682)
12. Sirima SB, Tiono AB, Gansane A et al. (2009) The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum. Malaria Journal 8, 48.
13. World Health Organization (2000) Management of severe malaria, a practical handbook. 2nd edn. WHO
14. World Health Organization (2001) Antimalarial Drug Combination Therapy: Report of a WHO Technical Consultation WHO/CDS/RBM/2001.35) WHO