Efficacy and safety of a fixed dose artesunate-sulphamethoxypyrazine- pyrimethamine compared to artemether-lumefantrine for the treatment of uncomplicated falciparum malaria across Africa: A randomized multi-centre trial

Malaria Journal

Volumn 8, Issue 1, 2009, Pages

  Sagara, Issaka ^a   Rulisa, Stephen ^b   Mbacham, Wilfred ^c   Adam, Ishag ^d   Sissoko, Kourane ^a   Maiga, Hamma ^a   Traore, Oumar B ^a   Dara, Niawanlou ^a   Dicko, Yahia T ^a   Dicko, Alassane ^a   Djimdé, Abdoulaye ^a   Jansen, F Herwig ^e   Doumbo, Ogobara K ^a  

^a UNIVERSITY OF BAMAKO   (Mali)

^b Teaching Hospital   (Rwanda)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^d UNIVERSITY OF KHARTOUM   (Sudan)

^e Dafra Pharma NV/SA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; ARTESUNATE PLUS METAKELFIN; CO ARINATE FDC; METAKELFIN; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; ARTEMETHER LUMEFANTRINE COMBINATION; ARTEMETHER-LUMEFANTRINE COMBINATION; ARTEMISININ DERIVATIVE; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; PYRIMETHAMINE; SULFALENE;

ABDOMINAL PAIN; ADOLESCENT; ADULT; AFRICA; AGED; ANEMIA; ANOREXIA; ARTICLE; CHILD; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOSAGE SCHEDULE COMPARISON; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; HEADACHE; HUMAN; INFANT; INTESTINE INFECTION; MAJOR CLINICAL STUDY; MALARIA; MALARIA FALCIPARUM; MALE; MULTICENTER STUDY; NAUSEA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SCHOOL CHILD; SKIN INFECTION; UNSPECIFIED SIDE EFFECT; VOMITING; WEAKNESS; ANIMAL; COMPARATIVE STUDY; DRUG ADMINISTRATION; DRUG COMBINATION; DRUG EFFECT; ISOLATION AND PURIFICATION; PLASMODIUM FALCIPARUM; PREGNANCY; PROSPECTIVE STUDY; TABLET; TREATMENT OUTCOME;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; ETHANOLAMINES; FEMALE; FLUORENES; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; PREGNANCY; PROSPECTIVE STUDIES; PYRIMETHAMINE; SULFALENE; TABLETS; TREATMENT OUTCOME;

EID: 65549167913     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-8-63     Document Type: Article

References (33)

1. Epidemiology of drug-resistant malaria. C Wongsrichanalai AL Pickard WH Wernsdorfer SR Meshnick, Lancet Infect Dis 2002 2 209 218 10.1016/S1473-3099(02) 00239-6 11937421 (Pubitemid 34464751)
2. The global distribution of clinical episodes of Plasmodium falciparum malaria. RW Snow CA Guerra AM Noor HY Myint SI Hay, Nature 2005 434 214 217 10.1038/nature03342 15759000 (Pubitemid 40388051)
3. Malaria. BM Greenwood K Bojang CJ Whitty GA Targett, Lancet 2005 365 1487 1498 10.1016/S0140-6736(05)66420-3 15850634 (Pubitemid 40591695)
4. World Health Organization, Guidelines for the treatment of malaria. Geneva
5. Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. M Adjuik P Agnamey A Babiker S Borrmann P Brasseur M Cisse F Cobelens S Diallo JF Faucher P Garner S Gikunda PG Kremsner S Krishna B Lell M Loolpapit PB Matsiegui MA Missinou J Mwanza F Ntoumi P Olliaro P Osimbo P Rezbach E Some WR Taylor, Lancet 2002 20 1365 1372 10.1016/S0140-6736(02)08348-4 (Pubitemid 34442375)
6. Artemether-lumefantrine for uncomplicated malaria: a systematic review. AA Omari C Gamble P Garner, Trop Med Int Health 2004 9 192 199 10.1046/j.1365-3156.2003.01186.x 15040555 (Pubitemid 38250805)
7. ®) tablets (six-dose regimen) in African infants and children with acute, uncomplicated falciparum malaria. C Falade M Makanga Z Premji CE Ortmann M Stockmeyer PI de Palacios, Trans R Soc Trop Med Hyg 2005 99 459 467 10.1016/j.trstmh.2004.09.013 15837358 (Pubitemid 40521344)
8. Assessment of the relative advantage of various artesunate-based combination therapies by a multi-treatment bayesian random-effects meta-analysis. FH Jansen E Lesaffre LK Penali MJ Zattera H Die-Kakou E Bissagnene, Am J Trop Med Hyg 2007 77 1005 1009 18165512
9. WHO guidelines for the treatment of malaria: Implication for the next generation of antimalarial medicines. K Mendis, Press release Global Malaria Programme, Washington 2005
10. A randomized trial of artesunate-sulfamethoxypyrazine-pyrimethamine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali. I Sagara A Dicko A Djimde O Guindo M Kone Y Tolo MA Thera M Sogoba M Fofana A Ouattara M Sissoko HF Jansen OK Doumbo, Am J Trop Med Hyg 2006 75 630 636 17038684 (Pubitemid 46941266)
11. Comparison of different artemisinin-based combinations for the treatment of Plasmodium falciparum malaria in children in Kigali, Rwanda, an area of resistance to sulfadoxine-pyrimethamine: artesunate plus sulfadoxine/ pyrimethamine versus artesunate plus sulfamethoxypyrazine/pyrimethamine. S Rulisa JP Gatarayiha T Kabarisa G Ndayisaba, Am J Trop Med Hyg 2007 77 612 616 17978058
12. Single day, three dose treatment with fixed dose combination artesunate/sulfamethoxypyrazine/pyrimethamine to cure P. falciparum malaria. LK Penali FH Jansen, Int J Infect Dis 2008 12 430 437 10.1016/j.ijid.2007.12.006 18343702
13. A fixed-dose 24-hour regimen of artesunate plus sulfamethoxypyrazine- pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan. I Adam M Magzoub ME Osman IF Khalil M Alifrangis KA Elmardi, Ann Clin Microbiol Antimicrob 2006 5 18 16934158 10.1186/1476-0711-5-18 (Pubitemid 44377710)
14. Therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine and the sulfadoxine-pyrimethamine-amodiaquine combination against uncomplicated Plasmodium falciparum malaria in young children in Cameroon. LK Basco A Same-Ekobo VF Ngane M Ndounga T Metoh P Ringwald G Soula, Bull World Health Organ 2002 80 538 545 12163917
15. Molecular epidemiology of malaria in Cameroon. XXVII: Clinical and parasitological response to sulfadoxine-pyrimethamine treatment and Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase alleles in Cameroonian children. R Tahar LK Basco, Acta Trop 2007 103 81 89 10.1016/j.actatropica.2007.04.008 17640607 (Pubitemid 47277439)
16. Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones. AA Djimdé A Dolo A Ouattara S Diakité CV Plowe OK Doumbo, J Infect Dis 2004 190 853 855 10.1086/422758 15272415 (Pubitemid 39050017)
17. Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria. AA Djimdé OK Doumbo O Traore AB Guindo K Kayentao Y Diourte S Niare-Doumbo D Coulibaly AK Kone Y Cissoko M Tekete B Fofana A Dicko DA Diallo TE Wellems D Kwiatkowski CV Plowe, Am J Trop Med Hyg 2003 69 558 563 14695097 (Pubitemid 38248261)
18. The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. East African Network for Monitoring Antimalarial Treatment (EANMAT), Trop Med Int Health 2003 8 860 867 10.1046/j.1360-2276.2003.01114.x 14516296 (Pubitemid 37304999)
19. Efficacy of chloroquine and sulfadoxine/pyrimethamine mono- and combined therapy against falciparum malaria in Sudan. SB Elamin el-FM Malik el-DS Ahmed EK Elabadil TA Mohamad, East Mediterr Health J 2007 13 25 34 17546902 (Pubitemid 47243837)
20. The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural Eastern Sudan: the interrelation between resistance, age and gametocytogenesis. IE Elbasit MI Elbashir IF Khalil M Alifrangis HA Giha, Trop Med Int Health 2006 11 604 612 10.1111/j.1365-3156. 2006.01616.x 16640612
21. Severe falciparum malaria. World Health Organization, Trans R Soc Trop Med Hyg 2000 94 S1 90 10.1016/S0035-9203(00)90300-6 11103309 (Pubitemid 30303682)
22. World Health Organization, Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. Geneva 50 1 68
23. A randomized trial of artesunate-mefloquine versus artemether- lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Mali. I Sagara A Diallo M Kone M Coulibaly SI Diawara O Guindo H Maiga MB Niambele M Sissoko A Dicko A Djimde OK Doumbo, Am J Trop Med Hyg 2008 79 655 661 18981499
24. The economic burden of malaria. JL Gallup JD Sachs, Am J Trop Med Hyg 2001 64 1-2 Suppl 85 96 11425181 (Pubitemid 32552575)
25. A comparative study on the efficacy of artesunate plus sulphadoxine/pyrimethamine versus artemether-lumefantrine in eastern Sudan. EA Mukhtar NB Gadalla SE El-Zaki I Mukhtar FA Mansour A Babiker BB El-Sayed, Malar J 2007 6 92 17631681 10.1186/1475-2875-6-92 (Pubitemid 47224885)
26. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. MR Kamya A Yeka H Bukirwa M Lugemwa JB Rwakimari SG Staedke AO Talisuna B Greenhouse F Nosten PJ Rosenthal F Wabwire-Mangen G Dorsey, PLoS Clin Trials 2007 2 5 e20 17525792 10.1371/journal.pctr.0020020 (Pubitemid 46860146)
27. Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug. RK Haynes HW Chan CM Lung NC Ng HN Wong LY Shek ID Williams A Cartwright MF Gomes, Chem Med Chem 2007 2 1448 1463 17694524
28. Chemical instability determines the biological action of the artemisinins. FH Jansen SA Soomro, Curr Med Chem 2007 14 3243 3259 10.2174/092986707782793844 18220758
29. Antimalarial combinations. PG Kremsner S Krishna, Lancet 2004 364 285 94 10.1016/S0140-6736(04)16680-4 15262108 (Pubitemid 38942820)
30. Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial. G Priotto J Kabakyenga L Pinoges A Ruiz T Eriksson F Coussement T Ngambe WR Taylor W Perea JP Guthmann P Olliaro D Legros, Trans R Soc Trop Med Hyg 2003 97 325 330 10.1016/S0035-9203(03)90161-1 15228253 (Pubitemid 39185891)
31. Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa. A Nahum A Erhart D Gazard C Agbowai C Van Overmeir H van Loen J Menten M Akogbeto M Coosemans A Massougbodji U D'Alessandro, Malar J 2007 6 170 18154655 10.1186/1475-2875-6-170
32. A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria. FP Mockenhaupt S Ehrhardt SY Dzisi J Teun Bousema N Wassilew J Schreiber SD Anemana JP Cramer RN Otchwemah RW Sauerwein TA Eggelte U Bienzle, Trop Med Int Health 2005 10 512 520 10.1111/j.1365-3156.2005.01427.x 15941413 (Pubitemid 40806656)
33. Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria. S Looareesuwan C Viravan S Vanijanonta P Wilairatana P Suntharasamai P Charoenlarp K Arnold D Kyle C Canfield K Webster, Lancet 1992 339 821 824 10.1016/0140-6736(92)90276-9 1347854