Different expression of the catalytic alpha subunits of the AMP activated protein kinase - an immunohistochemical study in human tissue

Histology and Histopathology

Volumn 26, Issue 5, 2011, Pages 589-596

  Quentin, Thomas ^a   Kitz, Julia ^a   Steinmetz, Michael ^a   Poppe, Andrea ^a   Bär, Karin ^a   Krätzner, Ralph ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

AMPK; Immunohistochemistry; Secretion

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOPROTEIN; PRKAA1 PROTEIN, HUMAN; PRKAA2 PROTEIN, HUMAN;

ARTICLE; BIOSYNTHESIS; CYTOLOGY; ENZYME ACTIVE SITE; GENE EXPRESSION REGULATION; HEART MUSCLE CELL; HELA CELL; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; PANCREAS ISLET; SKELETAL MUSCLE; TISSUE DISTRIBUTION; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; BLOTTING, WESTERN; CATALYTIC DOMAIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; MUSCLE, SKELETAL; MYOCYTES, CARDIAC; PROTEIN ISOFORMS; TISSUE DISTRIBUTION;

EID: 79960620794     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Birk J.B. and Wojtaszewski J.F.P. (2006). Predominant α2ß2/γ3 AMPK activation during exercise in human skeletal muscle. J. Physiol. 577 Pt 3, 1021-1032.
2. Bronner M., Hertz R. and Bar-Tana J. (2004). Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase. Biochem. J. 384 Pt 2, 295-305.
3. Carling D. (2004). The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem. Sci. 29, 18-24.
4. Conde E., Suarez-Gauthier A., Garcia-Garcia E., Lopez-Rios F., Lopez-Encuentra A., Garcia-Lujan R., Morente M., Sanchez-Verde L. and Sanchez-Cespedes M. (2007). Specific pattern of LKB1 and phosphor-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Human Pathol. 38, 1351-1360.
5. Dzamko N.L. and Steinberg G.R. (2009). AMPK-dependent hormonal regulation of whole-body energy metabolism. Acta Physiol. (Oxf) 196, 115-127.
6. Jansen M., Klooster J.P., Offerhaus G.J. and Clevers H. (2009). LKB1 and AMPK family signaling: The intimate link between cell polarity and energy metabolism. Physiol. Rev. 89, 77-798.
7. Kodiha M., Rassi J.G., Brown C.M. and Stochaj U. (2007). Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway. Am. J. Physiol. Cell. Physiol. 293, C1427-1436.
8. Lage R., Dieguez C., Vidal-Puig A. and Lopez M. (2008). AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol. Med. 14, 539-549.
9. McGee S.L. and Hargreaves M. (2010). AMPK-mediated regulation of transcription in skeletal muscle. Clin. Sci. 118, 507-518.
10. Sakamoto K., Zarrinpashneh E., Budas G.R., Pouleur A.C., Dutta A., Prescott A.R., Vanoverschelde J.L., Ashworth A., Jovanovic A., Alessi D.R. and Bertrand L. (2006). Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am. J. Physiol. Endocrinol. Metab. 290, E780-788.
11. Salt I., Celler J.W., Hawley S.A., Prescott A., Woods A., Carling D. and Hardie D.G. (1998). AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem. J. 334 Pt 1, 177-187.
12. Sidani S., Kopic S., Socrates T., Kirchhoff P., Foller M., Murek M., Capasso A. and Geibel J.P. (2009). AMP-activated protein kinase: a physiological off switch for murine gastric acid secretion. Pflugers Arch. 459, 39-46.
13. Stapleton D., Mitchelhill K.I., Gao G., Widmer J., Michell B.J., The T., House C.M., Fernandez C.S., Cox T., Witters L.A. and Kemp B.E. (1996). Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271, 611-614.
14. Tian R., Musi N., D'Agostino J., Hirshman M.F. and Goodyear J.L. (2001). Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 104, 1664-1669.
15. Tosca L., Froment P., Solnais P., Ferre P., Foufelle F. and Dupont J. (2005). Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells. Endocrinology 146, 4500-4513.
16. Tsuboi T., da Silva Xavier G., Leclerc I. and Rutter G.A. (2003). 5'-AMPactivated protein kinase controls insulin-containing secretory vesicle dynamics. J. Biol. Chem. 278, 52042-52051.
17. Wojtaszewski J.F., Nielsen P., Hansen B.F., Richter E.A. and Kiens B. (2000). Isoform-specific and exercise intensity-dependent activation of 5'-AMP-activated protein kinase in human skeletal muscle. J. Physiol. 528 Pt1, 221-226.
18. Wojtaszewski J.F., Birk J.B., Frosig C., Holten M., Pilegaard H. and Dela F. (2005). 5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes. J. Physiol. 528 Pt1, 221-226.