Release of theophylline and carbamazepine from matrix tablets - Consequences of HPMC chemical heterogeneity

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 78, Issue 3, 2011, Pages 470-479

  Viridén, Anna ^a   Abrahmsén Alami, Susanna ^b   Wittgren, Bengt ^b   Larsson, Anette ^a  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Batch to batch variability; Drug release; Drug solubility; HPMC chemical heterogeneity; Hydrophilic matrix tablets; MRI

Indexed keywords

CARBAMAZEPINE; HYDROXYPROPYLMETHYLCELLULOSE; THEOPHYLLINE;

ARTICLE; CELL HETEROGENEITY; DRUG RELEASE; EROSION; NUCLEAR MAGNETIC RESONANCE IMAGING;

CARBAMAZEPINE; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; METHYLCELLULOSE; PARTICLE SIZE; PHARMACOKINETICS; POLYMERS; POROSITY; POWDERS; SOLUBILITY; TABLETS; THEOPHYLLINE;

EID: 79960579041     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.02.003     Document Type: Article

References (38)

1. D.A. Alderman A review of cellulose ethers in hydrophilic matrixes for oral controlled - release dosage forms Int. J. Pharm. Technol. Prod. Manuf. 5 3 1984 1 9 (Pubitemid 15105124)
2. P. Colombo, R. Bettini, P. Santi, and N.A. Peppas Swellable matrixes for controlled drug delivery: gel-layer behavior, mechanisms and optimal performance Pharm. Sci. Technol. Today 3 6 2000 198 204 (Pubitemid 30364933)
3. D.G. Kanjickal, and S.T. Lopina Modeling of drug release from polymeric delivery systems - a review Crit. Rev. Ther. Drug Carrier Syst. 21 2004 345 386 (Pubitemid 41647577)
4. B. Narasimhan Mathematical models describing polymer dissolution: consequences for drug delivery Adv. Drug Deliv. Rev. 48 2-3 2001 195 210 (Pubitemid 32434403)
5. J. Siepmann, and N.A. Peppas Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) Adv. Drug Deliv. Rev. 48 2-3 2001 139 157 (Pubitemid 32434400)
6. J. Siepmann, K. Podual, M. Sriwongjanya, N.A. Peppas, and R. Bodmeier A new model describing the swelling and drug release kinetics from hydroxypropyl methyl cellulose tablets J. Pharm. Sci. 88 1 1999 65 72 (Pubitemid 29037370)
7. K. Tahara, K. Yamamoto, and T. Nishihata Overall mechanism behind matrix sustained-release (SR) tablets prepared with hydroxypropyl methyl cellulose 2910 J. Control. Release 35 1 1995 59 66
8. R.T.C. Ju, P.R. Nixon, and M.V. Patel Drug release from hydrophilic matrices. 1. New scaling laws for predicting polymer and drug release based on the polymer disentanglement concentration and the diffusion layer J. Pharm. Sci. 84 12 1995 1455 1463
9. K. Ueberreiter, and F. Asmussen Velocity of dissolution of polymers. Part I J. Polym. Sci. Part A 57 165 1962 187 198
10. M. Levina, and A.R. Rajabi-Siahboomi The influence of excipients on drug release from hydroxypropyl methylcellulose matrices J. Pharm. Sci. 93 11 2004 2746 2754 (Pubitemid 39506625)
11. F. Tajarobi, S. Abrahmsen-Alami, M. Hansen, and A. Larsson The impact of dose and solubility of additives on the release from HPMC matrix tablets-identifying critical conditions Pharm. Res. 26 6 2009 1496 1503
12. P. Colombo, R. Bettini, G. Massimo, P.L. Catellani, P. Santi, and N.A. Peppas Drug diffusion front movement is important in drug release control from swellable matrix tablets J. Pharm. Sci. 84 8 1995 991 997
13. P. Colombo, R. Bettini, P. Santi, A. De Ascentiis, and N.A. Peppas Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport J. Control. Release 39 2-3 1996 231 237 (Pubitemid 26194222)
14. P.I. Lee Controlled drug release from polymeric matrixes involving moving boundaries Controlled Release Pestic. Pharm 1981 39 48
15. N.A. Peppas, R. Gurny, E. Doelker, and P. Buri Modelling of drug diffusion through swellable polymeric systems J. Membr. Sci. 7 3 1980 241 253 (Pubitemid 11192790)
16. R. Bettini, P.L. Catellani, P. Santi, G. Massimo, N.A. Peppas, and P. Colombo Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate J. Control. Release 70 3 2001 383 391 (Pubitemid 32155461)
17. X.C. Fu, G.P. Wang, W.Q. Liang, and M.S.S. Chow Prediction of drug release from HPMC matrices: effect of physicochemical properties of drug and polymer concentration J. Control. Release 95 2 2004 209 216 (Pubitemid 38230036)
18. J.L. Ford, M.H. Rubinstein, and J.E. Hogan Propranolol hydrochloride and aminophylline release from matrix tablets containing hydroxypropyl methyl cellulose Int. J. Pharm. 24 2-3 1985 339 350 (Pubitemid 15062541)
19. M.V. Velasco, J.L. Ford, P. Rowe, and A.R. Rajabi-Siahhoomi Influence of drug:hydroxypropyl methyl cellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets J. Control. Release 57 1 1999 75 85 (Pubitemid 29005075)
20. P. Colombo, R. Bettini, P.L. Catellani, P. Santi, and N.A. Peppas Drug volume fraction profile in the gel phase and drug release kinetics in hydroxypropyl methyl cellulose matrixes containing a soluble drug Eur. J. Pharm. Sci. 9 1 1999 33 40 (Pubitemid 29430190)
21. J. Siepmann, and N.A. Peppas Hydrophilic matrixes for controlled drug delivery: an improved mathematical model to predict the resulting drug release kinetics (the "sequential layer" model) Pharm. Res. 17 10 2000 1290 1298
22. T.C. Dahl, T. Calderwood, A. Bormeth, K. Trimble, and E. Piepmeier Influence of physico-chemical properties of hydroxypropyl methylcellulose on naproxen release from sustained release matrix tablets J. Control. Release 14 1 1990 1 10 (Pubitemid 20305835)
23. J.L. Ford, M.H. Rubinstein, and J.E. Hogan Formulation of sustained-release promethazine hydrochloride tablets using hydroxypropyl methyl cellulose matrixes Int. J. Pharm. 24 2-3 1985 327 338 (Pubitemid 15062540)
24. A. Viridén, A. Larsson, H. Schagerlöf, and B. Wittgren Model drug release from matrix tablets composed of HPMC with different substituent heterogeneity Int. J. Pharm. 401 1-2 2010 60 67
25. P. Gao, J.W. Skoug, P.R. Nixon, T.R. Ju, N.L. Stemm, and K.-C. Sung Swelling of hydroxypropyl methylcellulose matrix tablets. 2. Mechanistic study of the influence of formulation variables on matrix performance and drug release J. Pharm. Sci. 85 7 1996 732 740 (Pubitemid 26234678)
26. N. Kavanagh, and O.I. Corrigan Swelling and erosion properties of hydroxypropylmethylcellulose (Hypromellose) matrices - influence of agitation rate and dissolution medium composition Int. J. Pharm. 279 1-2 2004 141 152 (Pubitemid 38968649)
27. T.D. Reynolds, S.H. Gehrke, A.S. Hussain, and L.S. Shenouda Polymer erosion and drug release characterization of hydroxypropyl hethylcellulose matrices J. Pharm. Sci. 87 9 1998 1115 1123 (Pubitemid 28452113)
28. A. Viriden, B. Wittgren, T. Andersson, and A. Larsson The effect of chemical heterogeneity of HPMC on polymer release from matrix tablets Eur. J. Pharm. Sci. 36 4-5 2009 392 400
29. A. Viriden, A. Larsson, and B. Wittgren The effect of substitution pattern of HPMC on polymer release from matrix tablets Int. J. Pharm. 389 1-2 2010 147 156
30. J.T. Fell, and J.M. Newton Determination of tablet strength by the diametral-compression test J. Pharm. Sci. 59 5 1970 688 691
31. S. Abrahmsen-Alami, A. Korner, I. Nilsson, and A. Larsson New release cell for NMR microimaging of tablets. Swelling and erosion of poly(ethylene oxide) Int. J. Pharm. 342 1-2 2007 105 114 (Pubitemid 47259338)
32. H. Schagerlöf, Enzymatic Hydrolysis of Cellulose Derivatives. Active Site Studies and Polymer Characterisation. Department of Biochemistry, Lund University, Lund, 2006.
33. M.E. Campos-Aldrete, and L. Villafuerte-Robles Influence of the viscosity grade and the particle size of HPMC on metronidazole release from matrix tablets Eur. J. Pharm. Biopharm. 43 2 1997 173 178 (Pubitemid 28298798)
34. M.A. Dabbagh, J.L. Ford, M.H. Rubinstein, and J.E. Hogan Effects of polymer particle size, compaction pressure and hydrophilic polymers on drug release from matrixes containing ethyl cellulose Int. J. Pharm. 140 1 1996 85 95 (Pubitemid 26276718)
35. M. Larsson, A. Viriden, M. Stading, and A. Larsson The influence of HPMC substitution pattern on solid-state properties Carbohydr. Polym. 82 4 2010 1074 1081
36. E. Kaunisto, S. Abrahmsen-Alami, P. Borgquist, A. Larsson, B. Nilsson, and A. Axelsson A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging J. Control. Release 147 2 2010 232 241
37. K. Mitchell, J.L. Ford, D.J. Armstrong, P.N.C. Elliott, J.E. Hogan, and C. Rostron The influence of the particle size of hydroxypropyl methyl cellulose K15M on its hydration and performance in matrix tablets Int. J. Pharm. 100 1-3 1993 175 179 (Pubitemid 23316329)
38. I. Katzhendler, R. Azoury, and M. Friedman Crystalline properties of carbamazepine in sustained release hydrophilic matrix tablets based on hydroxypropyl methylcellulose J. Control. Release 54 1 1998 69 85 (Pubitemid 28255239)