Model drug release from matrix tablets composed of HPMC with different substituent heterogeneity

International Journal of Pharmaceutics

Volumn 401, Issue 1-2, 2010, Pages 60-67

  Viriden A ^a   Larsson, Anette ^a   Schagerlöf, Herje ^b   Wittgren, Bengt ^c  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Batch to batch variation; Chemical heterogeneous; Drug release; Hydrophilic matrix tablets; Hydroxypropyl methylcellulose

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; METHYL PARABEN;

ARTICLE; CHEMICAL COMPOSITION; DIFFUSION; DRUG RELEASE; HYDROLYSIS; MATRIX TABLET; PRIORITY JOURNAL; SHEAR RATE; VISCOSITY;

CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; METHYLCELLULOSE; MOLECULAR WEIGHT; PARABENS; SOLUBILITY; TABLETS; TEMPERATURE; VISCOSITY;

EID: 78049297947     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.09.017     Document Type: Article

References (30)

1. Alderman D.A. A review of cellulose ethers in hydrophilic matrixes for oral controlled-release dosage forms. International Journal of Pharmaceutical Technology & Product Manufacture 1984, 5:1-9.
2. 1H NMR. Pharmeuropa 2003.
3. Blaug S., Ahsan S. Interactions of parabens with nonionic macromolecules. Journal of Pharmaceutical Sciences 1961, 50:441-443.
4. Bonferoni M.C., Rossi S., Ferrari F., Bertoni M., Sinistri R., Carmella C. Characterization of three hydroxypropyl methyl cellulose substitution types. Rheological properties and dissolution behavior. European Journal of Pharmaceutics and Biopharmaceutics 1995, 41:242-246.
5. Colombo P., Bettini R., Santi P., De Ascentiis A., Peppas N.A. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport. Journal of Controlled Release 1996, 39:231-237.
6. Dahl T.C., Calderwood T., Bormeth A., Trimble K., Piepmeier E. Influence of physico-chemical properties of hydroxypropyl methylcellulose on naproxen release from sustained release matrix tablets. Journal of Controlled Release 1990, 14:1-10.
7. De Gennes P.G. Scaling Concepts in Polymer Physics 1979, Cornell Univ. Press, Ithaca, NY.
8. Gao P., Skoug J.W., Nixon P.R., Ju T.R., Stemm N.L., Sung K.-C. Swelling of hydroxypropyl methylcellulose matrix tablets. 2. Mechanistic study of the influence of formulation variables on matrix performance and drug release. Journal of Pharmaceutical Sciences 1996, 85:732-740.
9. Haque A., Morris E.R. Thermogelation of methylcellulose. Part I. Molecular structures and processes. Carbohydrate Polymers 1993, 22:161-173.
10. Haque A., Richardson R.K., Morris E.R., Gidley M.J., Caswell D.C. Thermogelation of methylcellulose. Part II. Effect of hydroxypropyl substituents. Carbohydrate Polymers 1993, 22:175-186.
11. Hirrien M., Desbrieres J., Rinaudo M. Physical properties of methylcellulose in relation with the conditions for cellulose modification. Carbohydrate Polymers 1996, 31:243-252.
12. Ju R.T.C., Nixon P.R., Patel M.V. Drug release from hydrophilic matrices. 1. New scaling laws for predicting polymer and drug release based on the polymer disentanglement concentration and the diffusion layer. Journal of Pharmaceutical Sciences 1995, 84:1455-1463.
13. Karlsson J., Momcilovic D., Wittgren B., Schülein M., Tjerneld F., Brinkmalm G. Enzymatic degradation of carboxymethyl cellulose hydrolyzed by the endoglucanases Cel5A, Cel7B, and Cel45A from Humicola insolens and Cel7B, Cel12A and Cel45Acore from Trichoderma reesei. Biopolymers 2002, 63:32-40.
14. Karlsson J., Siika-Aho M., Tenkanen M., Tjerneld F. Enzymatic properties of the low molecular mass endoglucanases Cel12A (EG III) and Cel45A (EG V) of Trichoderma reesei. Journal of Biotechnology 2002, 99:63-78.
15. Kavanagh N., Corrigan O.I. Swelling and erosion properties of hydroxypropylmethylcellulose (Hypromellose) matrices-influence of agitation rate and dissolution medium composition. International Journal of Pharmaceutics 2004, 279:141-152.
16. Lapidus H., Lordi N.G. Drug release from compressed hydrophilic matrices. Journal of Pharmaceutical Sciences 1968, 57:1292-1301.
17. Melander C. New methods for enzyme hydrolysis, analysis, and characterization of modified cellulose. Analytical Chemistry 2006, Lund University, Lund.
18. Neely W.B. Solution properties of polysaccharides. IV. Molecular weight and aggregate formation in methylcellulose solutions. Journal of Polymer Science Part A 1963, 1:311-320.
19. European Pharmacopoeia 2006, Council of Europe, cop, Strasbourg. E. Pharmacopoeia (Ed.).
20. Reynolds T.D., Gehrke S.H., Hussain A.S., Shenouda L.S. Polymer erosion and drug release characterization of hydroxypropyl methylcellulose matrices. Journal of Pharmaceutical Sciences 1998, 87:1115-1123.
21. Richardson S., Gorton L. Characterisation of the substituent distribution in starch and cellulose derivatives. Analytica Chimica Acta 2003, 497:27-65.
22. Sarkar N. Thermal gelation properties of methyl and hydroxypropyl methylcellulose. Journal of Applied Polymer Science 1979, 24:1073-1087.
23. Schagerlof H., Johansson M., Richardson S., Brinkmalm G., Wittgren B., Tjerneld F. Substituent distribution and clouding behavior of hydroxypropyl methylcellulose analyzed using enzymatic degradation. Biomacromolecules 2006, 7:3474-3481.
24. Schagerlöf H. Enzymatic Hydrolysis of Cellulose Derivatives. Active Site Studies and Polymer Characterisation 2006, Department of Biochemistry, Lund University, Lund.
25. Silva S.M.C., Pinto F.V., Antunes F.E., Miguel M.G., Sousa J.J.S., Pais A.A.C.C. Aggregation and gelation in hydroxypropylmethyl cellulose aqueous solutions. Journal of Colloid and Interface Science 2008, 327:333-340.
26. Takahashi S.-I., Fujimoto T., Miyamoto T., Inagaki H. Relationship between distribution of substituents and water solubility of O-methyl cellulose. Journal of Polymer Science Part A: Polymer Chemistry 1987, 25:987-994.
27. USP29-NF24, U.S.P., 2003. United States Pharmacopeia.
28. Viriden A., Larsson A., Wittgren B. The effect of substitution pattern of HPMC on polymer release from matrix tablets. International Journal of Pharmaceutics 2010, 389:147-156.
29. Viriden A., Wittgren B., Andersson T., Abrahmsen-Alami S., Larsson A. Influence of substitution pattern on solution behavior of hydroxypropyl methylcellulose. Biomacromolecules 2009, 10:522-529.
30. Viriden A., Wittgren B., Andersson T., Larsson A. The effect of chemical heterogeneity of HPMC on polymer release from matrix tablets. European Journal of Pharmaceutical Sciences 2009, 36:392-400.