Drug volume fraction profile in the gel phase and drug release kinetics in hydroxypropylmethyl cellulose matrices containing a soluble drug

European Journal of Pharmaceutical Sciences

Volumn 9, Issue 1, 1999, Pages 33-40

  Colombo, Paolo ^a   Bettini, Ruggero ^a   Catellani, Pier Luigi ^a   Santi, Patrizia ^a   Peppas, Nikolaos A ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b Purdue University   (United States)

Author keywords

Drug transport; Gel layer; HPMC; Polymer relaxation; Swelling

Indexed keywords

BUFLOMEDIL; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER;

ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG RELEASE; DRUG SOLUBILITY; DRUG TRANSPORT; IMAGE ANALYSIS; MATRIX TABLET; NONHUMAN; PRIORITY JOURNAL;

EID: 0032870873     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(99)00039-1     Document Type: Article

References (15)

1. Adler J., Jayan A., Melia C.D. A method for quantifying differential expansion within hydrating hydrophilic matrixes by tracking embedded fluorescent microspheres. J. Pharm. Sci. 88:1999;371-377.
2. Bettini R., Colombo P., Massimo G., Catellani P.L., Vitali T. Swelling and drug release in hydrogel matrices: polymer viscosity and matrix porosity effects. Eur. J. Pharm. Sci. 2:1994;213-219.
3. Colombo P., Gazzaniga A., Caramella C., Conte U., La Manna A. In vitro programmable zero-order release drug delivery system. Acta Pharm. Technol. 33:1987;15-20.
4. Colombo P., Bettini R., Massimo G., Catellani P. L, Santi P., Peppas N.A. Drug diffusion front movement is important in drug release control from swellable matrix tablets. J. Pharm. Sci. 84:1995;991-997.
5. Colombo P., Bettini R., Santi P., Peppas N.A. The importance of drug diffusion front in drug delivery kinetics from swellable matrices. Pharm.Res. 14:1997;S532.
6. Colombo P., Bettini R., Peppas N.A. Observations of swelling process and diffusion front position during swelling in HPMC matrices containing a soluble drug. J. Control. Release. 61:1999;83-91.
7. Conte U., Colombo P., Gazzaniga A., Sangalli M.E., La Manna A. Swelling-activated drug delivery system. Biomaterials. 9:1988;489-493.
8. ® gels: measurement of drug concentration to release rate kinetics. Pharm. Res. 12:1995;1513-1520.
9. Gao P., Meury R.H. Swelling of hydroxypropylmethyl cellulose matrix tablets. 1. Characterization of swelling using a novel optical imaging method. J. Pharm. Sci. 85:1996;725-731.
10. Konrad R., Christ A., Zessin G., Cobet U. The use of ultrasound and penetrometer to characterize the advancement of swelling and eroding fronts in HPMC matrices. Int. J. Pharm. 163:1998;123-131.
11. Lee P.I. Controlled drug release from polymeric matrices involving moving boundaries. Levis D.H. Controlled Release of Pesticides and Pharmaceuticals. 1981;30-48 Plenum, New York.
12. Lindner W.D., Mokel J.E., Lippold B.C. Controlled release of drug from hydrocoloid embeddings. Pharmazie. 51:1996;263-272.
13. Peppas N.A. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv. 60:1985;110-111.
14. Peppas N.A., Gurny R., Doelker E., Buri P. Modelling of drug diffusion through swellable polymeric systems. J. Membr. Sci. 7:1980;241-253.
15. Rajabi-Siahboomi A.R., Bowtell R.W., Mansfield P., Davies M.C., Melia C.D. Structure and behavior in hydrophilic matrix sustained release dosage forms: 4. Studies of water mobility and diffusion coefficient in the gel layer of HPMC tablets using NMR imaging. Pharm. Res. 13:1996;376-380.