The association of the angiotensinogen gene with insulin sensitivity in humans: A tagging single nucleotide polymorphism and haplotype approach

Metabolism: Clinical and Experimental

Volumn 60, Issue 8, 2011, Pages 1150-1157

  Underwood, Patricia C ^a,b   Sun, Bei ^a   Williams, Jonathan S ^a   Pojoga, Luminita H ^a   Raby, Benjamin ^a   Lasky Su, Jessica ^a   Hunt, Steven ^c   Hopkins, Paul N ^c   Jeunemaitre, Xavier ^d   Adler, Gail K ^a   Williams, Gordon H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON COLLEGE   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSINOGEN; INSULIN;

ADULT; ALLELE; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GAIN OF FUNCTION MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HOMEOSTASIS; HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE; HOMOZYGOTE; HUMAN; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; ANGIOTENSINOGEN; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HAPLOTYPES; HUMANS; HYPERTENSION; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79960564182     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2010.12.009     Document Type: Article

References (38)

1. Watkins W.S., Hunt S.C., and Williams G.H. Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes J Hypertens 28 2010 65 75
2. Hopkins P.N., Lifton R.P., and Hollenberg N.K. Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity J Hypertens 14 1996 199 207 (Pubitemid 26121862)
3. Hopkins P.N., Hunt S.C., and Jeunemaitre X. Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension Circulation 105 2002 1921 1927 (Pubitemid 34437619)
4. Abuissa H., Jones P.G., and Marso S.P. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials J Am Coll Cardiol 46 2005 821 826 (Pubitemid 41224805)
5. The NAVIGATOR Study Group Effect of valsartan on the incidence of diabetes and cardiovascular events N Engl J Med 362 2010 1477 1490
6. DREAM Trial Investigators Effect of ramipril on the incidence of diabetes N Engl J Med 355 2006 1551 1562
7. Bonnet F., Patel S., and Laville M. Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects Diabetes Care 31 2008 789 794
8. Guo X., Cheng S., and Taylor K.D. Hypertension genes are genetic markers for insulin sensitivity and resistance Hypertension 45 2005 799 803 (Pubitemid 40418384)
9. Sheu W.H., Lee W.J., and Jeng C.Y. Angiotensinogen gene polymorphism is associated with insulin resistance in nondiabetic men with or without coronary heart disease Am Heart J 136 1998 125 131 (Pubitemid 28317877)
10. Takakura Y., Yoshida T., and Yoshioka K. Angiotensinogen gene polymorphism (Met235Thr) influences visceral obesity and insulin resistance in obese japanese women Metabolism 55 2006 819 824
11. Raji A., Williams G.H., and Jeunemaitre X. Insulin resistance in hypertensives: effect of salt sensitivity, renin status and sodium intake J Hypertens 19 2001 99 105 (Pubitemid 32099281)
12. Chamarthi B., Kolatkar N.S., and Hunt S.C. Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension J Clin Endocrinol Metab 92 2007 1340 1346 (Pubitemid 46556407)
13. Williams J.S., Williams G.H., and Jeunemaitre X. Influence of dietary sodium on the renin-angiotensin-aldosterone system and prevalence of left ventricular hypertrophy by EKG criteria J Hum Hypertens 19 2005 133 138 (Pubitemid 40227370)
14. Donovan D.S., Soloman C.G., and Seely E.W. Effect of sodium intake on salt sensitivity Am J Physiol 264 1993 730 734
15. Matthews D.R., Hosker J.P., and Rudenski A.S. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419 (Pubitemid 15018832)
16. International HAPMAP Consortium The International HAPMAP Project Nature 426 2003 789 796
17. den Dunnen J.T., and Antonarakis S.E. Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion Hum Mutat 15 2000 7 12 (Pubitemid 30036162)
18. Halangk J., Berg T., and Neumann K. Evaluation of angiotensinogen c. 1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver disease of various etiologies Gen Test Mol Bioma 13 2009 407 414
19. Purcell S., Neale B., and Todd-Brown K. PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 2007 559 575 (Pubitemid 47330214)
20. American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 33 2010 S62 S69
21. Lalouel J.M., Rohrwasser A., and Terreros D. Angiotensinogen in essential hypertension: from genetics to nephrology J Am Soc Nephrol 12 2001 606 615 (Pubitemid 32180032)
22. McLauglin T., Abbasi F., and Cheal K. Use of metabolic markers to identify overweight individuals who are insulin resistant Ann Intern Med 139 2003 802 809
23. Tsai C.T., Hwang J.J., and Lai L.P. Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort Atherosclerosis 203 2009 249 256
24. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults-the evidence report. national institutes of health Obes Res 6 1998 51S 209S
25. Inoue I., Nakajima J., and Williams C.S. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro J Clin Invest 99 1997 1786 1797 (Pubitemid 27164639)
26. Jeunemaitre X., Soubrier F., and Kotelevtsev Y.V. Molecular basis of human hypertension: role of angiotensinogen Cell 71 1992 169 180
27. Kim H.S., Krege J., and Kluckman K.D. Genetic control of blood pressure and angiotensinogen locus Proc Natl Acad Sci 92 1995 2735 2739
28. Fliser D., Arnold U., and Kohl B. Angiotensin II enhances insulin sensitivity in healthy volunteers under euglycemic conditions J Hypertens 11 1993 983 988 (Pubitemid 23277474)
29. Morris A.D., Petrie J.R., and Ueda S. Pressor and subpressor doses of angiotensin II increase insulin sensitivity in NIDDM. dissociation of metabolic and blood pressure effects Diabetes 43 1994 1445 1449
30. Jonk A.M., Houben A.J., and Schaper N.C. Angiotensin II enhances insulin-stimulated whole-body glucose disposal but impairs insulin-induced capillary recruitment in healthy volunteers J Clin Endocrinol Metab 95 2010 3901 3908
31. Buchanan T.A., Thawani H., and Kades W. Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism J Clin Invest 92 1993 720 726 (Pubitemid 23262390)
32. Juan C.C., Chien Y., and Wu L.Y. Angiotensin II enhances insulin sensitivity in vitro and in vivo Endocrinology 146 2005 2246 2254 (Pubitemid 40577512)
33. Garg R., Williams G.H., and Hurwitz S. Low-salt diet increases insulin resistance in healthy subjects Metabolism 2010 [October 29, Epub ahead of print]
34. Rahmouni K., Mark A.L., and Haynes W.G. Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity Am J Physiol Endocrinol Metab 286 2004 E891 E895
35. Jones B.H., Standridge M.K., and Taylor J.W. Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control Am J Physiol 273 1997 R236 R242
36. Saiki A., Ohira M., and Endo K. Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus Metabolism 58 2009 708 713
37. Jeunemaitre X., Inoue I., and Williams C.S. Haplotypes of angiotensinogen in essential hypertension Am J Hum Genet 60 1997 1448 1460 (Pubitemid 27258077)
38. Sethupathy P., Borel C., and Gagnebin M. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated regions: a mechanism for functional single-nucleotide polymorphisms related to phenotypes Am J Hum Genet 81 2007 405 413 (Pubitemid 47236088)