Trypanocidal activity of peptidyl vinyl ester derivatives selective for inhibition of mammalian proteasome trypsin-like activity

Experimental Parasitology

Volumn 128, Issue 4, 2011, Pages 444-447

  Steverding, Dietmar ^a   Baldisserotto, Anna ^b   Wang, Xia ^a   Marastoni, Mauro ^b  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Proteasome; Sleeping sickness; Trypanosoma brucei; Vinyl ester tripeptides

Indexed keywords

3 HYDROXY 2 METHYLBENZOYL LEUCYLLEUCYLLEUCINE VINYL ESTER; 3 HYDROXY 2 METHYLBENZOYL VALYLASPARAGINYLLEUCINE VINYL ESTER; 3 HYDROXY 2 METHYLBENZOYL VALYLGLUTAMINYLLEUCINE VINYL ESTER; 3 HYDROXY 2 METHYLBENZOYL VALYLSERYLLEUCINE VINYL ESTER; ANTITRYPANOSOMAL AGENT; BENZYLOXYCARBONYL LEUCYLLEUCYLLEUCINE VINYL ESTER; BENZYLOXYCARBONYL VALYLSERYLLEUCINE VINYL ESTER; GUVACINE LEUCYLLEUCYLLEUCINE VINYL ESTER; GUVACINE VALYLSERYLLEUCINE VINYL ESTER; PROTEASOME; PYRIDINE 3 CARBONYL VALYLGLUTAMINYLLEUCINE VINYL ESTER; TRYPTASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING; TRYPANOCIDAL ACTIVITY; TRYPANOSOMA BRUCEI;

ESTERS; HL-60 CELLS; HUMANS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPSIN INHIBITORS;

MAMMALIA; TRYPANOSOMA BRUCEI;

EID: 79960562551     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2011.03.015     Document Type: Article

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