Lower expression of PKAα impairs insulin secretion in islets isolated from low-density lipoprotein receptor (LDLR-/-) knockout mice

Metabolism: Clinical and Experimental

Volumn 60, Issue 8, 2011, Pages 1158-1164

  Bonfleur, Maria Lúcia ^a   Ribeiro, Rosane Aparecida ^b   Balbo, Sandra Lucinei ^a   Vanzela, Emerielle Cristine ^b   Carneiro, Everardo Magalhães ^b   Franco De Oliveira, Helena Coutinho ^b   Boschero, Antonio Carlos ^b  

^a UNIVERSIDADE ESTADUAL DO OESTE DO PARANÁ   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CALCIUM ION; CARBACHOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GLUCOSE; INSULIN; ISOBUTYLMETHYLXANTHINE; LOW DENSITY LIPOPROTEIN RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C BETA2; POTASSIUM CHLORIDE; PROTEIN KINASE A ALPHA; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CONTROLLED STUDY; FEMALE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; ISOLATED PANCREAS ISLET; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BLOOD GLUCOSE; CALCIUM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FASTING; FEMALE; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; PROTEIN KINASE C-ALPHA; RECEPTORS, LDL;

EID: 79960561698     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2010.12.010     Document Type: Article

References (39)

1. Fujimoto W.Y. Background and recruitment data for the U.S. Diabetes Prevention Program Diabetes Care 23 2000 B11 B13
2. Wilson P.W. Diabetes mellitus and coronary heart disease Am J Kidney Dis 32 1998 S89 100
3. Haffner S.M. Management of dyslipidemia in adults with diabetes Diabetes Care 21 1998 160 178 (Pubitemid 28030404)
4. Ginsberg H.N., Zhang Y.L., and Hernandez-Ono A. Regulation of plasma triglycerides in insulin resistance and diabetes Arch Med Res 36 2005 232 240 (Pubitemid 40755136)
5. Ginsberg H.N. Lipoprotein physiology in nondiabetic and diabetic states. Relationship to atherogenesis Diabetes Care 14 1991 839 855
6. Caparevic Z., Kostic N., and Ilic S. Oxidized LDL and C-reactive protein as markers for detection of accelerated atherosclerosis in type 2 diabetes Med Pregl 59 2006 160 164
7. Cohen M.P., Jin Y., and Lautenslager G.T. Increased plasma glycated low-density lipoprotein concentrations in diabetes: a marker of atherogenic risk Diabetes Technol Ther 6 2004 348 356 (Pubitemid 38821620)
8. Breslow J.L. Mouse models of atherosclerosis Science 272 1996 685 688 (Pubitemid 26000273)
9. Ishibashi S., Brown M.S., and Goldstein J.L. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery J Clin Invest 92 1993 883 893 (Pubitemid 23262411)
10. Merat S., Casanada F., and Sutphin M. Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet Arterioscler Thromb Vasc Biol 19 1999 1223 1230 (Pubitemid 29227641)
11. Schreyer S.A., Vick C., and Lystig T.C. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice Am J Physiol Endocrinol Metab 282 2002 E207 E214
12. Bonfleur M.L., Vanzela E.C., and Ribeiro R.A. Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity Biochim Biophys Acta 1801 2010 183 190
13. Scott A.M., Atwater I., and Rojas E. A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans Diabetologia 21 1981 470 475 (Pubitemid 11027869)
14. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
15. Newton A.C. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions Chem Rev 101 2001 2353 2364 (Pubitemid 35373023)
16. Xia F., Gao X., and Kwan E. Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis J Biol Chem 279 2004 24685 24691 (Pubitemid 38725336)
17. Schulla V., Renstrom E., and Feil R. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice Embo J 22 2003 3844 3854 (Pubitemid 36980594)
18. Iwashima Y., Abiko A., and Ushikubi F. Downregulation of the voltage-dependent calcium channel (VDCC) beta-subunit mRNAs in pancreatic islets of type 2 diabetic rats Biochem Biophys Res Commun 280 2001 923 932 (Pubitemid 32924522)
19. Straub S.G., and Sharp G.W. Glucose-stimulated signaling pathways in biphasic insulin secretion Diabetes Metab Res Rev 18 2002 451 463 (Pubitemid 36041600)
20. Gembal M., Detimary P., and Gilon P. Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells J Clin Invest 91 1993 871 880 (Pubitemid 23095261)
21. Gembal M., Gilon P., and Henquin J.C. Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells J Clin Invest 89 1992 1288 1295
22. Sato Y., Aizawa T., and Komatsu M. Dual functional role of membrane depolarization/Ca2+ influx in rat pancreatic B-cell Diabetes 41 1992 438 443
23. Jones P.M., and Persaud S.J. Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells Endocr Rev 19 1998 429 461 (Pubitemid 29116376)
24. Boschero A.C., Szpak-Glasman M., and Carneiro E.M. Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors Am J Physiol 268 1995 E336 E342
25. Malaisse W.J., Pipeleers D.G., and Levy J. The stimulus-secretion coupling of glucose-induced insulin release. XVI. A glucose-like and calcium-independent effect of cyclic AMP Biochim Biophys Acta 362 1974 121 128
26. Dyachok O., Idevall-Hagren O., and Sagetorp J. Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion Cell Metab 8 2008 26 37 (Pubitemid 351859229)
27. Thorens B. GLP-1 and the control of insulin secretion Journ Annu Diabetol Hotel Dieu 1994 33 46
28. Szecowka J., Grill V., and Sandberg E. Effect of GIP on the secretion of insulin and somatostatin and the accumulation of cyclic AMP in vitro in the rat Acta Endocrinol (Copenh) 99 1982 416 421 (Pubitemid 12165003)
29. Huypens P., Ling Z., and Pipeleers D. Glucagon receptors on human islet cells contribute to glucose competence of insulin release Diabetologia 43 2000 1012 1019 (Pubitemid 30655721)
30. Seino S., and Shibasaki T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis Physiol Rev 85 2005 1303 1342 (Pubitemid 41362272)
31. Hatakeyama H., Kishimoto T., and Nemoto T. Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets J Physiol 570 2006 271 282
32. Chheda M.G., Ashery U., and Thakur P. Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex Nat Cell Biol 3 2001 331 338 (Pubitemid 32288439)
33. Nagy G., Reim K., and Matti U. Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25 Neuron 41 2004 417 429 (Pubitemid 38228352)
34. Wang X., Zhou J., and Doyle M.E. Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism Endocrinology 142 2001 1820 1827 (Pubitemid 32405938)
35. Ferreira F., Barbosa H.C., and Stoppiglia L.F. Decreased insulin secretion in islets from rats fed a low protein diet is associated with a reduced PKAalpha expression J Nutr 134 2004 63 67 (Pubitemid 38057424)
36. Milanski M., Arantes V.C., and Ferreira F. Low-protein diets reduce PKAalpha expression in islets from pregnant rats J Nutr 135 2005 1873 1878 (Pubitemid 41099744)
37. Takahashi N., Kadowaki T., and Yazaki Y. Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells Proc Natl Acad Sci U S A 96 1999 760 765 (Pubitemid 29061282)
38. Henquin J.C. Cellular mechanisms of the control of insulin secretion Arch Int Physiol Biochim 98 1990 A61 A80
39. Kasai H., Suzuki T., and Liu T.T. Fast and cAMP-sensitive mode of Ca(2+)-dependent exocytosis in pancreatic beta-cells Diabetes 51 2002 S19 S24