Simultaneous determination of 3,3′,4′,5,7-pentamethylquercetin and its possible metabolite 3,3′,4′,7-tetramethylquercetin in dog plasma by liquid chromatography-tandem mass spectrometry and its application to preclinical pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 23, 2011, Pages 2339-2344

  Chen, Xiaomei ^a   Li, Dongyan ^a   Hu, Yan ^a   Jin, Manwen ^a   Zhou, Liping ^a   Peng, Kelong ^a   Zheng, Heng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

3,3 ,4 ,5,7 pentamethylquercetin; 3,3 ,4 ,7 tetramethylquercetin; LC MS MS; Pharmacokinetic

Indexed keywords

ANALYTES; DOG PLASMA; ESI-MS/MS; INTERNAL STANDARDS; ION PAIRS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MOBILE PHASE; ORAL DOSE; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; PROTEIN PRECIPITATION; SIMULTANEOUS DETERMINATIONS; ULTRA-FAST LIQUID CHROMATOGRAPHY;

ACETONITRILE; BIOMOLECULES; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHARMACOKINETICS;

LIQUID CHROMATOGRAPHY;

3,3',4',5,7 PENTAMETHYLQUERCETIN; 3,3',4',7 TETRAMETHYLQUERCETIN; ACETONITRILE; APIGENIN DERIVATIVE; QUERCETIN DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STABILITY; EXPERIMENTAL DOG; INSTRUMENT VALIDATION; ION PAIR EXTRACTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, LIQUID; DOGS; MALE; QUERCETIN; TANDEM MASS SPECTROMETRY;

CANIS FAMILIARIS;

EID: 79960559551     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.06.019     Document Type: Article

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