-
1
-
-
33748753067
-
Bacterial clearance and mortality are not improved by a combination of IL-10 neutralization and IFN-gamma administration in a murine model of post-CLP immunosuppression
-
Murphey, E. D., and E. R. Sherwood. 2006. Bacterial clearance and mortality are not improved by a combination of IL-10 neutralization and IFN-gamma administration in a murine model of post-CLP immunosuppression. Shock 26: 417-424.
-
(2006)
Shock
, vol.26
, pp. 417-424
-
-
Murphey, E.D.1
Sherwood, E.R.2
-
2
-
-
5444241502
-
Diminished bacterial clearance is associated with decreased IL-12 and interferon-gamma production but a sustained proinflammatory response in a murine model of postseptic immunosuppression
-
Murphey, E. D., C. Y. Lin, R. W. McGuire, T. Toliver-Kinsky, D. N. Herndon, and E. R. Sherwood. 2004. Diminished bacterial clearance is associated with decreased IL-12 and interferon-gamma production but a sustained proinflammatory response in a murine model of postseptic immunosuppression. Shock 21: 415-425.
-
(2004)
Shock
, vol.21
, pp. 415-425
-
-
Murphey, E.D.1
Lin, C.Y.2
McGuire, R.W.3
Toliver-Kinsky, T.4
Herndon, D.N.5
Sherwood, E.R.6
-
3
-
-
77950208700
-
Characterization and modulation of the immunosuppressive phase of sepsis
-
Muenzer, J. T., C. G. Davis, K. Chang, R. E. Schmidt, W. M. Dunne, C. M. Coopersmith, and R. S. Hotchkiss. 2010. Characterization and modulation of the immunosuppressive phase of sepsis. Infect. Immun. 78: 1582-1592.
-
(2010)
Infect. Immun.
, vol.78
, pp. 1582-1592
-
-
Muenzer, J.T.1
Davis, C.G.2
Chang, K.3
Schmidt, R.E.4
Dunne, W.M.5
Coopersmith, C.M.6
Hotchkiss, R.S.7
-
4
-
-
33748793685
-
Physiological functions of caspases beyond cell death
-
Nhan, T. Q., W. C. Liles, and S. M. Schwartz. 2006. Physiological functions of caspases beyond cell death. Am. J. Pathol. 169: 729-737.
-
(2006)
Am. J. Pathol.
, vol.169
, pp. 729-737
-
-
Nhan, T.Q.1
Liles, W.C.2
Schwartz, S.M.3
-
5
-
-
0026507126
-
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
-
Thornberry, N. A., H. G. Bull, J. R. Calaycay, K. T. Chapman, A. D. Howard, M. J. Kostura, D. K. Miller, S. M. Molineaux, J. R. Weidner, J. Aunins, et al. 1992. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356: 768-774.
-
(1992)
Nature
, vol.356
, pp. 768-774
-
-
Thornberry, N.A.1
Bull, H.G.2
Calaycay, J.R.3
Chapman, K.T.4
Howard, A.D.5
Kostura, M.J.6
Miller, D.K.7
Molineaux, S.M.8
Weidner, J.R.9
Aunins, J.10
-
6
-
-
2542457495
-
Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
-
DOI 10.1016/j.cell.2004.05.004, PII S0092867404004908
-
Martinon, F., and J. Tschopp. 2004. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117: 561-574. (Pubitemid 38692523)
-
(2004)
Cell
, vol.117
, Issue.5
, pp. 561-574
-
-
Martinon, F.1
Tschopp, J.2
-
7
-
-
37549002511
-
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
-
Shao, W., G. Yeretssian, K. Doiron, S. N. Hussain, and M. Saleh. 2007. The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J. Biol. Chem. 282: 36321-36329.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 36321-36329
-
-
Shao, W.1
Yeretssian, G.2
Doiron, K.3
Hussain, S.N.4
Saleh, M.5
-
8
-
-
0027449187
-
Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
-
DOI 10.1016/0092-8674(93)90486-A
-
Miura, M., H. Zhu, R. Rotello, E. A. Hartwieg, and J. Yuan. 1993. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75: 653-660. (Pubitemid 23346364)
-
(1993)
Cell
, vol.75
, Issue.4
, pp. 653-660
-
-
Miura, M.1
Zhu, H.2
Rotello, R.3
Hartwieg, E.A.4
Yuan, J.5
-
9
-
-
26844452231
-
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
-
Mariathasan, S., D. S. Weiss, V. M. Dixit, and D. M. Monack. 2005. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J. Exp. Med. 202: 1043-1049.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1043-1049
-
-
Mariathasan, S.1
Weiss, D.S.2
Dixit, V.M.3
Monack, D.M.4
-
10
-
-
0028984948
-
Mice deficient in IL-1 betaconverting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
-
Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld, et al. 1995. Mice deficient in IL-1 betaconverting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80: 401-411.
-
(1995)
Cell
, vol.80
, pp. 401-411
-
-
Li, P.1
Allen, H.2
Banerjee, S.3
Franklin, S.4
Herzog, L.5
Johnston, C.6
McDowell, J.7
Paskind, M.8
Rodman, L.9
Salfeld, J.10
-
11
-
-
0018964280
-
Sepsis and septic shock - A review of laboratory models and a proposal
-
Wichterman, K. A., A. E. Baue, and I. H. Chaudry. 1980. Sepsis and septic shock - a review of laboratory models and a proposal. J. Surg. Res. 29: 189-201.
-
(1980)
J. Surg. Res.
, vol.29
, pp. 189-201
-
-
Wichterman, K.A.1
Baue, A.E.2
Chaudry, I.H.3
-
12
-
-
7744246745
-
Static and dynamic assessment of biomarkers in surgical patients with severe sepsis
-
PROWESS Surgical Evaluation Committee
-
Lowry, S. F., S. Awad, H. Ford, W. Cheadle, M. D. Williams, R. L. Qualy, J. S. McCollam, B. M. Bates, D. E. Fry; PROWESS Surgical Evaluation Committee. 2004. Static and dynamic assessment of biomarkers in surgical patients with severe sepsis. Surg. Infect. (Larchmt) 5: 261-268.
-
(2004)
Surg. Infect. (Larchmt)
, vol.5
, pp. 261-268
-
-
Lowry, S.F.1
Awad, S.2
Ford, H.3
Cheadle, W.4
Williams, M.D.5
Qualy, R.L.6
McCollam, J.S.7
Bates, B.M.8
Fry, D.E.9
-
13
-
-
4544231442
-
The anti-inflammatory response dominates after septic shock: Association of low monocyte HLA-DR expression and high interleukin-10 concentration
-
Monneret, G., M. E. Finck, F. Venet, A. L. Debard, J. Bohé, J. Bienvenu, and A. Lepape. 2004. The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration. Immunol. Lett. 95: 193-198.
-
(2004)
Immunol. Lett.
, vol.95
, pp. 193-198
-
-
Monneret, G.1
Finck, M.E.2
Venet, F.3
Debard, A.L.4
Bohé, J.5
Bienvenu, J.6
Lepape, A.7
-
14
-
-
0141871978
-
Use of intracellular cytokine staining and bacterial superantigen to document suppression of the adaptive immune system in injured patients
-
discussion 410-411
-
Murphy, T., H. Paterson, S. Rogers, J. A. Mannick, and J. A. Lederer. 2003. Use of intracellular cytokine staining and bacterial superantigen to document suppression of the adaptive immune system in injured patients. Ann. Surg. 238: 401-410, discussion 410-411.
-
(2003)
Ann. Surg.
, vol.238
, pp. 401410
-
-
Murphy, T.1
Paterson, H.2
Rogers, S.3
Mannick, J.A.4
Lederer, J.A.5
-
15
-
-
1542373661
-
Injury, sepsis, and the regulation of Toll-like receptor responses
-
Murphy, T. J., H. M. Paterson, J. A. Mannick, and J. A. Lederer. 2004. Injury, sepsis, and the regulation of Toll-like receptor responses. J. Leukoc. Biol. 75: 400-407.
-
(2004)
J. Leukoc. Biol.
, vol.75
, pp. 400-407
-
-
Murphy, T.J.1
Paterson, H.M.2
Mannick, J.A.3
Lederer, J.A.4
-
16
-
-
23444446083
-
Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis
-
Natanson, C., W. D. Hoffman, A. F. Suffredini, P. Q. Eichacker, and R. L. Danner. 1994. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann. Intern. Med. 120: 771-783.
-
(1994)
Ann. Intern. Med.
, vol.120
, pp. 771-783
-
-
Natanson, C.1
Hoffman, W.D.2
Suffredini, A.F.3
Eichacker, P.Q.4
Danner, R.L.5
-
17
-
-
0030746482
-
Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment
-
Zeni, F., B. Freeman, and C. Natanson. 1997. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit. Care Med. 25: 1095-1100.
-
(1997)
Crit. Care Med.
, vol.25
, pp. 1095-1100
-
-
Zeni, F.1
Freeman, B.2
Natanson, C.3
-
18
-
-
34250848196
-
Chronic sepsis mortality characterized by an individualized inflammatory response
-
Osuchowski, M. F., K. Welch, H. Yang, J. Siddiqui, and D. G. Remick. 2007. Chronic sepsis mortality characterized by an individualized inflammatory response. J. Immunol. 179: 623-630.
-
(2007)
J. Immunol.
, vol.179
, pp. 623-630
-
-
Osuchowski, M.F.1
Welch, K.2
Yang, H.3
Siddiqui, J.4
Remick, D.G.5
-
19
-
-
33748072117
-
Mechanisms of mortality in early and late sepsis
-
Xiao, H., J. Siddiqui, and D. G. Remick. 2006. Mechanisms of mortality in early and late sepsis. Infect. Immun. 74: 5227-5235.
-
(2006)
Infect. Immun.
, vol.74
, pp. 5227-5235
-
-
Xiao, H.1
Siddiqui, J.2
Remick, D.G.3
-
20
-
-
0035862535
-
Considering immunomodulatory therapies in the septic patient: Should apoptosis be a potential therapeutic target?
-
Oberholzer, A., C. Oberholzer, R. M. Minter, and L. L. Moldawer. 2001. Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target? Immunol. Lett. 75: 221-224.
-
(2001)
Immunol. Lett.
, vol.75
, pp. 221-224
-
-
Oberholzer, A.1
Oberholzer, C.2
Minter, R.M.3
Moldawer, L.L.4
-
21
-
-
56549120527
-
Lymphocyte apoptosis, caspase activation and inflammatory response in septic shock
-
Delogu, G., G. Famularo, G. Tellan, M. Marandola, A. Antonucci, M. Signore, S. Marcellini, and S. Moretti. 2008. Lymphocyte apoptosis, caspase activation and inflammatory response in septic shock. Infection 36: 485-487.
-
(2008)
Infection
, vol.36
, pp. 485-487
-
-
Delogu, G.1
Famularo, G.2
Tellan, G.3
Marandola, M.4
Antonucci, A.5
Signore, M.6
Marcellini, S.7
Moretti, S.8
-
22
-
-
34247646636
-
Targeting caspase-1 by inhalation-therapy: Effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
-
DOI 10.1007/s00134-007-0588-0
-
Boost, K. A., S. Hoegl, C. Hofstetter, M. Flondor, K. Stegewerth, I. Platacis, J. Pfeilschifter, H. Muhl, and B. Zwissler. 2007. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia. Intensive Care Med. 33: 863-871. (Pubitemid 46675323)
-
(2007)
Intensive Care Medicine
, vol.33
, Issue.5
, pp. 863-871
-
-
Boost, K.A.1
Hoegl, S.2
Hofstetter, C.3
Flondor, M.4
Stegewerth, K.5
Platacis, I.6
Pfeilschifter, J.7
Muhl, H.8
Zwissler, B.9
-
23
-
-
33750580090
-
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18
-
Sarkar, A., M. W. Hall, M. Exline, J. Hart, N. Knatz, N. T. Gatson, and M. D. Wewers. 2006. Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am. J. Respir. Crit. Care Med. 174: 1003-1010.
-
(2006)
Am. J. Respir. Crit. Care Med.
, vol.174
, pp. 1003-1010
-
-
Sarkar, A.1
Hall, M.W.2
Exline, M.3
Hart, J.4
Knatz, N.5
Gatson, N.T.6
Wewers, M.D.7
-
24
-
-
5944251623
-
Caspase inhibitors improve survival in sepsis: A critical role of the lymphocyte
-
Hotchkiss, R. S., K. C. Chang, P. E. Swanson, K. W. Tinsley, J. J. Hui, P. Klender, S. Xanthoudakis, S. Roy, C. Black, E. Grimm, et al. 2000. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat. Immunol. 1: 496-501.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 496-501
-
-
Hotchkiss, R.S.1
Chang, K.C.2
Swanson, P.E.3
Tinsley, K.W.4
Hui, J.J.5
Klender, P.6
Xanthoudakis, S.7
Roy, S.8
Black, C.9
Grimm, E.10
-
25
-
-
77949892535
-
VX-166: A novel potent small molecule caspase inhibitor as a potential therapy for sepsis
-
Weber, P., P. Wang, S. Maddens, P. Sh. Wang, R. Wu, M. Miksa, W. Dong, M. Mortimore, J. M. Golec, and P. Charlton. 2009. VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. Crit. Care 13: R146.
-
(2009)
Crit. Care
, vol.13
-
-
Weber, P.1
Wang, P.2
Maddens, S.3
Wang, P.Sh.4
Wu, R.5
Miksa, M.6
Dong, W.7
Mortimore, M.8
Golec, J.M.9
Charlton, P.10
-
26
-
-
0028845730
-
Cloning of a new cytokine that induces IFN-gamma production by T cells
-
Okamura, H., H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378: 88-91.
-
(1995)
Nature
, vol.378
, pp. 88-91
-
-
Okamura, H.1
Tsutsi, H.2
Komatsu, T.3
Yutsudo, M.4
Hakura, A.5
Tanimoto, T.6
Torigoe, K.7
Okura, T.8
Nukada, Y.9
Hattori, K.10
-
27
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan, S., D. S. Weiss, K. Newton, J. McBride, K. O'Rourke, M. Roose-Girma, W. P. Lee, Y. Weinrauch, D. M. Monack, and V. M. Dixit. 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-232.
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
McBride, J.4
O'Rourke, K.5
Roose-Girma, M.6
Lee, W.P.7
Weinrauch, Y.8
Monack, D.M.9
Dixit, V.M.10
-
28
-
-
33644985564
-
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
-
Sutterwala, F. S., Y. Ogura, M. Szczepanik, M. Lara-Tejero, G. S. Lichtenberger, E. P. Grant, J. Bertin, A. J. Coyle, J. E. Galán, P. W. Askenase, and R. A. Flavell. 2006. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24: 317-327.
-
(2006)
Immunity
, vol.24
, pp. 317-327
-
-
Sutterwala, F.S.1
Ogura, Y.2
Szczepanik, M.3
Lara-Tejero, M.4
Lichtenberger, G.S.5
Grant, E.P.6
Bertin, J.7
Coyle, A.J.8
Galán, J.E.9
Askenase, P.W.10
Flavell, R.A.11
-
29
-
-
34247118826
-
Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling
-
DOI 10.1016/j.immuni.2007.03.008, PII S1074761307002117
-
Kanneganti, T. D., M. Lamkanfi, Y. G. Kim, G. Chen, J. H. Park, L. Franchi, P. Vandenabeele, and G. Núñez. 2007. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 26: 433-443. (Pubitemid 46603000)
-
(2007)
Immunity
, vol.26
, Issue.4
, pp. 433-443
-
-
Kanneganti, T.-D.1
Lamkanfi, M.2
Kim, Y.-G.3
Chen, G.4
Park, J.-H.5
Franchi, L.6
Vandenabeele, P.7
Nunez, G.8
-
30
-
-
33744493091
-
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
-
Miao, E. A., C. M. Alpuche-Aranda, M. Dors, A. E. Clark, M. W. Bader, S. I. Miller, and A. Aderem. 2006. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7: 569-575.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 569-575
-
-
Miao, E.A.1
Alpuche-Aranda, C.M.2
Dors, M.3
Clark, A.E.4
Bader, M.W.5
Miller, S.I.6
Aderem, A.7
-
31
-
-
33744464740
-
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
-
Franchi, L., A. Amer, M. Body-Malapel, T. D. Kanneganti, N. Ozören, R. Jagirdar, N. Inohara, P. Vandenabeele, J. Bertin, A. Coyle, et al. 2006. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 7: 576-582.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 576-582
-
-
Franchi, L.1
Amer, A.2
Body-Malapel, M.3
Kanneganti, T.D.4
Ozören, N.5
Jagirdar, R.6
Inohara, N.7
Vandenabeele, P.8
Bertin, J.9
Coyle, A.10
-
32
-
-
37549041954
-
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
-
Sutterwala, F. S., L. A. Mijares, L. Li, Y. Ogura, B. I. Kazmierczak, and R. A. Flavell. 2007. Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J. Exp. Med. 204: 3235-3245.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 3235-3245
-
-
Sutterwala, F.S.1
Mijares, L.A.2
Li, L.3
Ogura, Y.4
Kazmierczak, B.I.5
Flavell, R.A.6
|