Comparative analysis of predictive models for nongenotoxic hepatocarcinogenicity using both toxicogenomics and quantitative structure-activity relationships

Chemical Research in Toxicology

Volumn 24, Issue 7, 2011, Pages 1062-1070

  Liu, Zhichao ^a   Kelly, Reagan ^b   Fang, Hong ^b   Ding, Don ^b   Tong, Weida ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b ICF INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; ACETYLSALICYLIC ACID; ALCOHOL; CARBON TETRACHLORIDE; CATECHOL; CHLORAMBUCIL; CHLOROFORM; CHOLINE; DICHLORVOS; DIPYRONE; ERGOCALCIFEROL; ESTRADIOL; GRISEOFULVIN; HYDRAZINE; IFOSFAMIDE; ISONIAZID; LEAD ACETATE; MERCAPTOPURINE; NAFENOPIN; NITROFURANTOIN; PARACETAMOL; PHENACETIN; PHENOBARBITAL; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PIRINIXIC ACID; PREDNISOLONE; PROPYLTHIOURACIL; RIFAMPICIN; UNINDEXED DRUG; VINYLIDENE CHLORIDE;

AMINO ACID METABOLISM; ARTICLE; BIOASSAY; BIOLOGICAL MODEL; CARCINOGENICITY; CELL CYCLE; CELL DEATH; CELL INTERACTION; CELL MOTION; CONTROLLED STUDY; CYTOSKELETON; GENE EXPRESSION PROFILING; GENOMICS; INTERMETHOD COMPARISON; LIVER CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; NONHUMAN; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TOXICOGENOMICS; VALIDATION STUDY;

ANIMALS; CARCINOGENS; DATABASES, FACTUAL; GENE EXPRESSION PROFILING; LIVER; MICE; MODELS, ANIMAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SOFTWARE; TIME FACTORS; TOXICITY TESTS; TOXICOGENETICS;

ANIMALIA; RATTUS; RODENTIA;

EID: 79960527011     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx2000637     Document Type: Article

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