Altered connectivity and action model formation in autism is autism

Neuroscientist

Volumn 17, Issue 4, 2011, Pages 437-448

  Mostofsky, Stewart H ^a   Ewen, Joshua B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

action models; autism; cerebral connectivity; EEG; motor function

Indexed keywords

ATTENTION DEFICIT DISORDER; AUTISM; BEHAVIOR; BRAIN REGION; DIFFUSION TENSOR IMAGING; ELECTROENCEPHALOGRAPHY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GESTURE; HUMAN; INTERNAL ACTION MODEL; INTERPERSONAL COMMUNICATION; MOTOR PERFORMANCE; PRIORITY JOURNAL; PSYCHOLOGICAL MODEL; REVIEW; SENSORY FEEDBACK; SOCIAL INTERACTION;

AUTISTIC DISORDER; CEREBRAL CORTEX; EXECUTIVE FUNCTION; HUMANS; MODELS, NEUROLOGICAL; MODELS, PSYCHOLOGICAL; MOTOR SKILLS DISORDERS; NEURAL PATHWAYS;

EID: 79960519991     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/1073858410392381     Document Type: Review

References (87)

1. Diagnostic and statistical manual of mental disorders. 4 th ed. Washington, DC: American Psychiatric Association ; 2000 :
2. Baron-Cohen S, Leslie AM, Frith U. Does the autistic child have a "theory of mind"?. Cognition. 1985 ; 21 (1). 37-46
3. Basar E, Basar-Eroglu C, Karakas S, Schurmann M. Gamma, alpha, delta, and theta oscillations govern cognitive processes. Int J Psychophysiol. 2001 ; 39 (2-3). 241-8 (Pubitemid 32041270)
4. Beilin H, Fireman G. The foundation of Piaget's theories: mental and physical action. Adv Child Dev Behav. 1999 ; 27: 221-46
5. Belmonte MK, Allen G, Beckel-Mitchener A, Boulanger LM, Carper RA, Webb SJ. Autism and abnormal development of brain connectivity. J Neurosci. 2004 ; 24 (42). 9228-31 (Pubitemid 39426157)
6. Boggio PS, Nunes A, Rigonatti SP, Nitsche MA, Pascual-Leone A, Fregni F. Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients. Restor Neurol Neurosci. 2007 ; 25 (2). 123-9 (Pubitemid 47290440)
7. BoriaSFabbri-DestroMCattaneoLSparaciLSinigagliaCSantelliE and others. 2009. Intention understanding in autism. PLoS One4(5):e5596.
8. Brieber S, Herpertz-Dahlmann B, Fink GR, Kamp-Becker I, Remschmidt H, Konrad K. Coherent motion processing in autism spectrum disorder (ASD): an fMRI study. Neuropsychologia. 2010 ; 48 (6). 1644-51
9. Prevalence of autism spectrum disorders-Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR. 2009 ; 58 (SS-10). 1-20
10. Cheng Y, Chou KH, Chen IY, Fan YT, Decety J, Lin CP. Atypical development of white matter microstructure in adolescents with autism spectrum disorders. Neuroimage. 2010 ; 50 (3). 873-82
11. Cherkassky VL, Kana RK, Keller TA, Just MA. Functional connectivity in a baseline resting-state network in autism. Neuroreport. 2006 ; 17 (16). 1687-90 (Pubitemid 44621565)
12. Coben R, Clarke AR, Hudspeth W, Barry RJ. EEG power and coherence in autistic spectrum disorder. Clin Neurophysiol. 2008 ; 119 (5). 1002-9
13. Courchesne E. Brain development in autism: early overgrowth followed by premature arrest of growth. Ment Retard Dev Disabil Res Rev. 2004 ; 10 (2). 106-11 (Pubitemid 39329015)
14. Crocetti D, Srinivasan P, Izawa J, Shadmehr R, Mostofsky S. Sensorimotor DTI abnormality is associated with anomalous motor learning in autism. Paper presented at: Ninth International Meeting for Autism Research ; 2010 Philadelphia, PA ; 2010..
15. Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci. 2006 ; 9 (1). 28-30 (Pubitemid 43011906)
16. DeMeyer MK, Alpern GD, Barton S, DeMyer WE, Churchill DW, Hingtgen JN. Imitation in autistic, early schizophrenic, and non-psychotic subnormal children. J Autism Child Schizophr. 1972 ; 2 (3). 264-87
17. Dewey D, Cantell M, Crawford SG. Motor and gestural performance in children with autism spectrum disorders, developmental coordination disorder, and/or attention deficit hyperactivity disorder. J Int Neuropsychol Soc. 2007 ; 13 (2). 246-56 (Pubitemid 46487356)
18. Dowell LR, Mahone EM, Mostofsky SH. Associations of postural knowledge and basic motor skill with dyspraxia in autism: implication for abnormalities in distributed connectivity and motor learning. Neuropsychology. 2009 ; 23 (5). 563-70
19. Dziuk MA, Gidley Larson JC, Apostu A, Mahone EM, Denckla MB, Mostofsky SH. Dyspraxia in autism: association with motor, social, and communicative deficits. Dev Med Child Neurol. 2007 ; 49 (10). 734-9 (Pubitemid 47456447)
20. Feder KP, Majnemer A. Handwriting development, competency, and intervention. Dev Med Child Neurol. 2007 ; 49 (4). 312-7 (Pubitemid 46477258)
21. Fletcher PT, Whitaker RT, Tao R, DuBray MB, Froehlich A, Ravichandran C. Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism. Neuroimage. 2010 ; 51 (3). 1117-25
22. Frazier TW, Hardan AY. A meta-analysis of the corpus callosum in autism. Biol Psychiatry. 2009 ; 66 (10). 935-41
23. Fries P, Nikolic D, Singer W. The gamma cycle. Trends Neurosci. 2007 ; 30 (7). 309-16 (Pubitemid 46991120)
24. Fritsch B, Reis J, Martinowich K, Schambra HM, Ji Y, Cohen LG. Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron. 2010 ; 66 (2). 198-204
25. Fuentes CT, Mostofsky SH, Bastian AJ. Children with autism show specific handwriting impairments. Neurology. 2009 ; 73 (19). 1532-7
26. Gallese V. Embodied simulation: from mirror neuron systems to interpersonal relations. Novartis Found Symp. 2007 ; 278: 3-12
27. Geschwind N. Disconnexion syndromes in animals and man: I. Brain. 1965 ; 88 (2). 237-94
28. Ghaziuddin M, Butler E. Clumsiness in autism and Asperger syndrome: a further report. J Intellect Disabil Res. 1998 ; 42 (Pt 1). 43-8 (Pubitemid 28349724)
29. Gidley Larson J, Mostofsky S Autism: a neurological disorder of early brain development. Tuchman R Rapin I, ed. London: Mac Keith Press for the International Review of Child Neurology Series ; 2006 :
30. Grafton ST. Embodied cognition and the simulation of action to understand others. Ann N Y Acad Sci. 2009 ; 1156: 97-117
31. Ham H, Bartolo A, Corley M, Rajendran G, Szabo A, Swanson S. Exploring the relationship between gestural recognition and imitation: evidence of dyspraxia in autism spectrum disorders. J Autism Dev Disord. 2010 ;:
32. Ham HS, Bartolo A, Corley M, Swanson S, Rajendran G. Case report: selective deficit in the production of intransitive gestures in an individual with autism. Cortex. 2010 ; 46 (3). 407-9
33. Haswell CC, Izawa J, Dowell LR, Mostofsky SH, Shadmehr R. Representation of internal models of action in the autistic brain. Nat Neurosci. 2009 ; 12 (8). 970-2
34. Heilman KM, Valenstein E Clinical neuropsychology. Oxford, UK: Oxford University Press ; 2003 :
35. Herbert MR, Ziegler DA, Makris N, Filipek PA, Kemper TL, Normandin JJ. Localization of white matter volume increase in autism and developmental language disorder. Ann Neurol. 2004 ; 55 (4). 530-40 (Pubitemid 38391970)
36. Hofvander B, Delorme R, Chaste P, Nyden A, Wentz E, Stahlberg O. Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders. BMC Psychiatry. 2009 ; 9: 35
37. Iacoboni M, Mazziotta JC. Mirror neuron system: basic findings and clinical applications. Ann Neurol. 2007 ; 62 (3). 213-8 (Pubitemid 47525396)
38. Iacoboni M, Molnar-Szakacs I, Gallese V, Buccino G, Mazziotta JC, Rizzolatti G. Grasping the intentions of others with one's own mirror neuron system. PLoS Biol. 2005 ; 3 (3). e79
39. Jansiewicz EM, Goldberg MC, Newschaffer CJ, Denckla MB, Landa R, Mostofsky SH. Motor signs distinguish children with high functioning autism and Asperger's syndrome from controls. J Autism Dev Disord. 2006 ; 36 (5). 613-21 (Pubitemid 44336984)
40. Just MA, Cherkassky VL, Keller TA, Kana RK, Minshew NJ. Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry. Cereb Cortex. 2007 ; 17 (4). 951-61 (Pubitemid 46434636)
41. Just MA, Cherkassky VL, Keller TA, Minshew NJ. Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain. 2004 ; 127 (Pt 8). 1811-21 (Pubitemid 39061557)
42. Kana RK, Keller TA, Cherkassky VL, Minshew NJ, Just MA. Sentence comprehension in autism: thinking in pictures with decreased functional connectivity. Brain. 2006 ; 129 (Pt 9). 2484-93 (Pubitemid 44522132)
43. Kanner L. Autistic disturbances of affective conduct. Nervous Child. 1943 ; 2: 217-250
44. Kennedy DP, Courchesne E. Functional abnormalities of the default network during self- and other-reflection in autism. Soc Cogn Affect Neurosci. 2008a ; 3 (2). 177-90 (Pubitemid 351827061)
45. Kennedy DP, Courchesne E. The intrinsic functional organization of the brain is altered in autism. Neuroimage. 2008b ; 39 (4). 1877-85
46. Kirton A, Deveber G, Gunraj C, Chen R. Cortical excitability and interhemispheric inhibition after subcortical pediatric stroke: plastic organization and effects of rTMS. Clin Neurophysiol. 2010 ; 121 (11). 1922-9
47. Kleinhans NM, Richards T, Sterling L, Stegbauer KC, Mahurin R, Johnson LC. Abnormal functional connectivity in autism spectrum disorders during face processing. Brain. 2008 ; 131 (Pt 4). 1000-12 (Pubitemid 351499416)
48. Klin A, Jones W, Schultz R, Volkmar F. The enactive mind, or from actions to cognition: lessons from autism. Philos Trans R Soc Lond B Biol Sci. 2003 ; 358 (1430). 345-60 (Pubitemid 36257607)
49. Kogan MD, Blumberg SJ, Schieve LA, Boyle CA, Perrin JM, Ghandour RM. Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007. Pediatrics. 2009 ; 124 (5). 1395-403
50. Korzeniewska A, Crainiceanu CM, Kus R, Franaszczuk PJ, Crone NE. Dynamics of event-related causality in brain electrical activity. Hum Brain Mapp. 2008 ; 29 (10). 1170-92
51. Koshino H, Carpenter PA, Minshew NJ, Cherkassky VL, Keller TA, Just MA. Functional connectivity in an fMRI working memory task in high-functioning autism. Neuroimage. 2005 ; 24 (3). 810-21 (Pubitemid 40094563)
52. Lee JE, Bigler ED, Alexander AL, Lazar M, DuBray MB, Chung MK. Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism. Neurosci Lett. 2007 ; 424 (2). 127-32 (Pubitemid 47285507)
53. Lee PS, Yerys BE, Della Rosa A, Foss-Feig J, Barnes KA, James JD. Functional connectivity of the inferior frontal cortex changes with age in children with autism spectrum disorders: a fcMRI study of response inhibition. Cereb Cortex. 2009 ; 19 (8). 1787-94
54. Liebetanz D, Nitsche MA, Paulus W. Pharmacology of transcranial direct current stimulation: missing effect of riluzole. Suppl Clin Neurophysiol. 2003 ; 56: 282-7
55. Lombardo MV, Chakrabarti B, Bullmore ET, Sadek SA, Pasco G, Wheelwright SJ. Atypical neural self-representation in autism. Brain. 2010 ; 133 (Pt 2). 611-24
56. Martineau J, Cochin S, Magne R, Barthelemy C. Impaired cortical activation in autistic children: is the mirror neuron system involved?. Int J Psychophysiol. 2008 ; 68 (1). 35-40
57. Mason RA, Williams DL, Kana RK, Minshew N, Just MA. Theory of mind disruption and recruitment of the right hemisphere during narrative comprehension in autism. Neuropsychologia. 2008 ; 46 (1). 269-80
58. Monk CS, Peltier SJ, Wiggins JL, Weng SJ, Carrasco M, Risi S. Abnormalities of intrinsic functional connectivity in autism spectrum disorders. Neuroimage. 2009 ; 47 (2). 764-72
59. Monk CS, Weng SJ, Wiggins JL, Kurapati N, Louro HM, Carrasco M. Neural circuitry of emotional face processing in autism spectrum disorders. J Psychiatry Neurosci. 2010 ; 35 (2). 105-14
60. Montalbano R, Roccella M. The quality of life of children with pervasive developmental disorders. Minerva Pediatr. 2009 ; 61 (4). 361-70
61. Moss J, Howlin P. Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider autism spectrum disorder population. J Intellect Disabil Res. 2009 ; 53 (10). 852-73
62. Mostofsky S, Izawa J, Marko M, Pekny S, Dowell L, Shadmehr R. Evidence for specificity of anomalous motor learning in autism. Paper presented at: Ninth International Meeting for Autism Research ; 2010 Philadelphia, PA ; 2010..
63. Mostofsky SH, Burgess MP, Gidley Larson JC. Increased motor cortex white matter volume predicts motor impairment in autism. Brain. 2007 ; 130 (Pt 8). 2117-22 (Pubitemid 47236619)
64. Mostofsky SH, Dubey P, Jerath VK, Jansiewicz EM, Goldberg MC, Denckla MB. Developmental dyspraxia is not limited to imitation in children with autism spectrum disorders. J Int Neuropsychol Soc. 2006 ; 12 (3). 314-26 (Pubitemid 43970897)
65. Mostofsky SH, Powell SK, Simmonds DJ, Goldberg MC, Caffo B, Pekar JJ. Decreased connectivity and cerebellar activity in autism during motor task performance. Brain. 2009 ; 132 (Pt 9). 2413-25
66. Murias M, Webb SJ, Greenson J, Dawson G. Resting state cortical connectivity reflected in EEG coherence in individuals with autism. Biol Psychiatry. 2007 ; 62 (3). 270-3 (Pubitemid 47042024)
67. Noterdaeme M, Mildenberger K, Minow F, Amorosa H. Evaluation of neuromotor deficits in children with autism and children with a specific speech and language disorder. Eur Child Adolesc Psychiatry. 2002 ; 11 (5). 219-25 (Pubitemid 36041691)
68. Perez MA, Cohen LG. The corticospinal system and transcranial magnetic stimulation in stroke. Top Stroke Rehabil. 2009 ; 16 (4). 254-69
69. Reis J, Robertson E, Krakauer JW, Rothwell J, Marshall L, Gerloff C. Consensus: "Can tDCS and TMS enhance motor learning and memory formation?". Brain Stimul. 2008 ; 1 (4). 363-9
70. Reis J, Schambra HM, Cohen LG, Buch ER, Fritsch B, Zarahn E. Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation. Proc Natl Acad Sci U S A. 2009 ; 106 (5). 1590-5
71. Rinehart NJ, Bellgrove MA, Tonge BJ, Brereton AV, Howells-Rankin D, Bradshaw JL. An examination of movement kinematics in young people with high-functioning autism and Asperger's disorder: further evidence for a motor planning deficit. J Autism Dev Disord. 2006 ; 36 (6). 757-67 (Pubitemid 44284980)
72. Rinehart NJ, Tonge BJ, Iansek R, McGinley J, Brereton AV, Enticott PG. Gait function in newly diagnosed children with autism: cerebellar and basal ganglia related motor disorder. Dev Med Child Neurol. 2006 ; 48 (10). 819-24 (Pubitemid 44425688)
73. Rogers S, Pennington B. A theoretical approach to the deficits in infantile autism. Dev Psychopathol. 1991 ; 3: 137-62
74. Sahyoun CP, Belliveau JW, Soulieres I, Schwartz S, Mody M. Neuroimaging of the functional and structural networks underlying visuospatial vs. linguistic reasoning in high-functioning autism. Neuropsychologia. 2010 ; 48 (1). 86-95
75. Shadmehr R. Generalization as a behavioral window to the neural mechanisms of learning internal models. Hum Mov Sci. 2004 ; 23 (5). 543-68 (Pubitemid 40012392)
76. Shadmehr R, Krakauer JW. A computational neuroanatomy for motor control. Exp Brain Res. 2008 ; 185 (3). 359-81
77. Shadmehr R, Mussa-Ivaldi FA. Adaptive representation of dynamics during learning of a motor task. J Neurosci. 1994 ; 14 (5 Pt 2). 3208-24 (Pubitemid 24139004)
78. Singer W. Neuronal synchrony: a versatile code for the definition of relations?. Neuron. 1999 ; 24 (1). 49 111-65 25
79. Solomon M, Ozonoff SJ, Ursu S, Ravizza S, Cummings N, Ly S. The neural substrates of cognitive control deficits in autism spectrum disorders. Neuropsychologia. 2009 ; 47 (12). 2515-26
80. Villalobos ME, Mizuno A, Dahl BC, Kemmotsu N, Muller RA. Reduced functional connectivity between V1 and inferior frontal cortex associated with visuomotor performance in autism. Neuroimage. 2005 ; 25 (3). 916-25 (Pubitemid 40461729)
81. Weng SJ, Wiggins JL, Peltier SJ, Carrasco M, Risi S, Lord C. Alterations of resting state functional connectivity in the default network in adolescents with autism spectrum disorders. Brain Res. 2010 ; 1313: 202-14
82. Wheaton L, Fridman E, Bohlhalter S, Vorbach S, Hallett M. Left parietal activation related to planning, executing and suppressing praxis hand movements. Clin Neurophysiol. 2009 ; 120 (5). 980-6
83. Wheaton LA, Hallett M. Ideomotor apraxia: a review. J Neurol Sci. 2007 ; 260 (1-2). 1-10 (Pubitemid 47214628)
84. Wheaton LA, Nolte G, Bohlhalter S, Fridman E, Hallett M. Synchronization of parietal and premotor areas during preparation and execution of praxis hand movements. Clin Neurophysiol. 2005 ; 116 (6). 1382-90 (Pubitemid 40839346)
85. Wheaton LA, Shibasaki H, Hallett M. Temporal activation pattern of parietal and premotor areas related to praxis movements. Clin Neurophysiol. 2005 ; 116 (5). 1201-12 (Pubitemid 40514390)
86. Williams JH. Self-other relations in social development and autism: multiple roles for mirror neurons and other brain bases. Autism Res. 2008 ; 1 (2). 73-90
87. Williams JH, Whiten A, Singh T. A systematic review of action imitation in autistic spectrum disorder. J Autism Dev Disord. 2004 ; 34 (3). 285-99 (Pubitemid 38860210)