Exposure to an environmental neurotoxicant hastens the onset of amyotrophic lateral sclerosis-like phenotype in human Cu2+/Zn2+ superoxide dismutase 1 G93A mice: Glutamate-mediated excitotoxicity

Journal of Pharmacology and Experimental Therapeutics

Volumn 338, Issue 2, 2011, Pages 518-527

  Johnson, Frank O ^a,b   Yuan, Yukun ^a,b   Hajela, Ravindra K ^a,b   Chitrakar, Alisha ^b   Parsell, Dawn M ^b   Atchison, William D ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; CALCIUM CHELATING AGENT; CALCIUM ION; COPPER ZINC SUPEROXIDE DISMUTASE; DRINKING WATER; GLUTAMIC ACID; METHYLMERCURY; N ACETYLSPERMINE; N,N,N',N' TETRAKIS(PYRIDYLMETHYL)ETHYLENEDIAMINE; NEUROTOXIN; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG; ZINC ION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EXCITOTOXICITY; FEMALE; FLUORESCENCE; GENE MUTATION; HYPOGLOSSAL NUCLEUS; MALE; MOTONEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; TONGUE; WILD TYPE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; EXCITATORY AMINO ACID AGONISTS; GENETIC PREDISPOSITION TO DISEASE; GLUTAMIC ACID; HUMANS; MALE; METHYLMERCURY COMPOUNDS; MICE; MICE, TRANSGENIC; PHENOTYPE; SUPEROXIDE DISMUTASE;

EID: 79960516739     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.174466     Document Type: Article

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