Mu and delta, but not kappa, opioid agonists induce spastic paraparesis after a short period of spinal cord ischaemia in rats

British Journal of Anaesthesia

Volumn 96, Issue 1, 2006, Pages 88-94

  Kakinohana, M ^a   Nakamura, S ^a   Fuchigami, T ^a   Davison, K J ^b   Marsala, M ^c   Sugahara, K ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c University of California   (United States)

Author keywords

Agonists, DAMGO, DPDPE, U50488H; Complications, paraparesis; Complications, spinal cord ischaemia; Receptors, opioid

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MU OPIATE RECEPTOR AGONIST; NALOXONE; NALTRINDOLE; OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA BALLOON; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG RECEPTOR BINDING; MALE; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RAT STRAIN; SPASTIC PARAPLEGIA; SPINAL CORD ISCHEMIA;

EID: 31144473576     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aei285     Document Type: Article

References (22)

1. Chaney MA. High-dose intrathecal morphine for thoracoabdominal aneurysm repair. J Cardiothorac Vasc Anesth 1996; 10: 306-7
2. De Riu PL, Petruzzi V, Palmieri G, et al. Beta-endorphine in experimental canine spinal ischaemia. Stroke 1989; 20: 253-8
3. Faden AI, Jacobs TP, Smith MT, Zivin JA. Naloxone in experimental spinal cord ischaemia: Dose-response studies. Eur J Pharmacol 1984; 103: 115-20
4. Kakinohana M, Marsala M, Carter C, et al. Neuraxial morphine may trigger transient spasticity after a noninjurious interval of spinal cord ischaemia: A clinical and experimental study. Anesthesiology 2003; 98: 862-70
5. Kakinohana M, Fuchigami T, Nakamura S, et al. Intrathecal administration of morphine, but not small dose, induced spastic paraparesis after a noninjurious interval of aortic occlusion in rats. Anesth Analg 2003; 96: 769-75
6. Kakinohana M, Kakinohana O, Jun HJ, et al. The activation of spinal N-methyl-D-aspartate receptors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischaemia. Anesth Analg 2005; 100: 327-34
7. Yaksh TL. Pharmacology and mechanisms of opioid analgesic activity. In: Yaksh TL, Lynch C III, Zapol WM, et al. eds. Anaesthesia: Biologic Fundations. Philadelphia: Lippincott-Raven, 1997; 921-34
8. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 17: 1031-6
9. Taira Y, Marsala M. Effect of proximal arterial perfusion pressure on function, spinal cord blood flow, and histopathologic changes after increasing intervals of aortic occlusion in the rat. Stroke 1996; 27: 1850-8
10. Kakinohana M, Taira Y, Marsala M. The effect of graded postischemic spinal cord hypothermia on neurological outcome and histopathology after transient spinal ischaemia in rat. Anesthesiology 1999; 90: 789-98
11. Benecke R. Basic neurophysiological mechanisms in spasticity. In: Marsden CD, ed. Treating Spasticity: Pharmacological Advances. Toronto: Hans Huber, 1989; 11-19
12. Ting P, Xu S, Krumins S. Endogeneous opioid system activity following temporary focal cerebral ischaemia. Acta Neurochir Suppl 1994; 60: 253-6
13. Marsala J, Sulla I, Santa M, et al. Mapping of the canine lumbosacral spinal cord neurons by Nauta method at the end of the early phase of paraplegia induced by ischaemia and reperfusion. Neuroscience 1991; 45: 479-94
14. Marsala M, Sorkin LS, Yaksh TL. Transient spinal cord ischaemia in rat: Characterization of spinal cord blood flow, extracellular amino acid release, and concurrent histopathological damage. J Cereb Blood Flow Metab 1994; 14: 604-14
15. Homma S, Suzuki T, Murayama S, Otsuka M. Amino acid and substance P contents in spinal cord of cats with experimental hind-limb rigidity produced by occlusion of spinal cord blood supply. J Neurochem 1979; 32: 691-8
16. Curtis DR, Duggan AW. The depression of spinal inhibition by morphine. Agents Actions 1969; 1: 14-19
17. Werz MA, Macdonald RL. Opiate alkaloids antagonized postsynaptic glycine and GABA responces: Correlation with convulsant action. Brain Res 1982; 236: 107-19
18. Wilcox GL, Seybold V. Pharmacology of spinal afferent processing. In: Yaksh TL, Lynch C III, Zapol WM, et al. eds. Anaesthesia: Biologic Fundations. Philadelphia: Lippincott-Raven, 1997; 557-76
19. Wilcox GL. Excitatory neurotoransmitters and pain. In: Bond M, Woolf CJ, Charlton JE, eds. Pain Research and Clinical Management: Proceedings of the Sixth World Congress on Pain. Amsterdam: Elsevier Science (Biomedical Division), 1991; 97-117
20. Nakamura S, Kakinohana M, Sugahara K, Kinjo S, Miyata Y. Intrathecal morphine, but not buprenorphine or pentazocine, can induce spastic paraparesis after a short lasting of spinal cord ischaemia in the rat. Anesth Analg 2004; 99: 1528-31
21. Malmberg AB, Yaksh TL. Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: Effects of naltrindole and its benzofuran analog (NTB). J Pharmacol Exp Ther 1992; 263: 264-75
22. Fuchigami T, Kakinohana M, Taira Y, et al. Repetitive intrathecal administration of morphine induces irreversible paraparesis after noninjurious interval of spinal cord ischaemia in the rat. Biologia (Bratisl) 1999; 54: 51-60