Development of a fit-for-purpose large-scale synthesis of an oral PARP inhibitor

Organic Process Research and Development

Volumn 15, Issue 4, 2011, Pages 831-840

  Wallace, Debra J ^a   Baxter, Carl A ^a   Brands, Karel J M ^a   Bremeyer, Nadine ^a   Brewer, Sarah E ^a   Desmond, Richard ^b   Emerson, Khateeta M ^a   Foley, Jennifer ^b   Fernandez, Paul ^b   Hu, Weifeng ^c   Keen, Stephen P ^a   Mullens, Peter ^a   Muzzio, Daniel ^b   Sajonz, Peter ^b   Tan, Lushi ^b   Wilson, Robert D ^a   Zhou, George ^b   Zhou, Guoyue ^c  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c WUXI APPTEC   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHIC SEPARATIONS; LARGE SCALE SYNTHESIS; OPERATIONAL IMPROVEMENTS; PARP-INHIBITOR; POLY(ADP-RIBOSE) POLYMERASE; SAFETY EVALUATIONS;

LIQUID CHROMATOGRAPHY;

EID: 79960483896     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op2000783     Document Type: Article

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