Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 488-492

  Scarpelli, Rita ^a   Boueres, Julia K ^a   Cerretani, Mauro ^a   Ferrigno, Federica ^a   Ontoria, Jesus M ^a   Rowley, Michael ^a   Schultz Fademrecht, Carsten ^a   Toniatti, Carlo ^a   Jones, Philip ^a  

^a IRBM   (Italy)

Author keywords

2 Phenyl 2H indazole 7 carboxamides; PARP inhibitor; Poly(ADP ribose) polymerase

Indexed keywords

2 PHENYL 2H INDAZOLE 7 CARBOXAMIDE; 5 FLUORO 2 PHENYL 2H INDAZOLE 7 CARBOXAMIDE; AMIDE; AZETIDINE; BRCA1 PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PROTEIN DEFICIENCY; RAT; STRAIN DIFFERENCE; STRUCTURE ACTIVITY RELATION; WILD TYPE;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; AZETIDINES; ENZYME INHIBITORS; HELA CELLS; HUMANS; INDAZOLES; POLY(ADP-RIBOSE) POLYMERASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN-PROTEIN LIGASES;

RATTUS;

EID: 72249100571     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.127     Document Type: Article

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