Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase Cγ that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation

Journal of Pharmacological Sciences

Volumn 114, Issue 2, 2010, Pages 206-216

  Seki, Takahiro ^a   Takahashi, Hideyuki ^b   Yamamoto, Kazuhiro ^a   Ogawa, Kota ^a   Onji, Tomoya ^a   Adachi, Naoko ^b   Tanaka, Shigeru ^a   Hide, Izumi ^a   Saito, Naoaki ^b   Sakai, Norio ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Aggregation; Cerebellar purkinje cell; Congo red; Protein kinase C ( PKC); Spinocerebellar ataxia type 14 (SCA14)

Indexed keywords

CONGO RED; GREEN FLUORESCENT PROTEIN; PROTEIN KINASE C GAMMA; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; GENE MUTATION; MOUSE; NERVE CELL CULTURE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PURKINJE CELL; SPINOCEREBELLAR ATAXIA TYPE 14; SPINOCEREBELLAR DEGENERATION; WILD TYPE;

EID: 78349302308     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10170FP     Document Type: Article

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