The SH2 domains of inositol polyphosphate 5-phosphatases SHIP1 and SHIP2 have similar ligand specificity but different binding kinetics

Biochemistry

Volumn 48, Issue 46, 2009, Pages 11075-11083

  Zhang, Yanyan ^a   Wavreille, Anne Sophie ^a   Kunys, Andrew R ^a   Pei, Dehua ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; BINDING BEHAVIORS; BINDING KINETICS; CIS-TRANS ISOMERIZATION; CONFORMATIONAL ISOMERS; CONSENSUS SEQUENCE; DIPHOSPHATES; DISSOCIATION RATES; IN-VIVO; KINETIC STUDY; LIGAND SPECIFICITY; PEPTIDE LIBRARY; PHOSPHATIDYLINOSITOL; POLYPHOSPHATES; POTENTIAL MECHANISM; PROLINE RESIDUES; PROLYL BONDS; SEQUENCE IDENTITY; SEQUENCE SPECIFICITY; SH2 DOMAIN; SITE DIRECTED MUTAGENESIS; SPECIFICITY PROFILE; SURFACE PLASMONS; TISSUE DISTRIBUTIONS; TRANS CONFIGURATION; TRIPHOSPHATE; TWO DOMAINS;

ALCOHOLS; AMINES; AMINO ACIDS; ASSOCIATION REACTIONS; BINDING ENERGY; DISSOCIATION; ISOMERIZATION; PEPTIDES; SUGARS; SURFACE PLASMON RESONANCE;

ISOMERS;

PEPTIDE LIBRARY; PROTEIN SHIP1; PROTEIN SHIP2; SYNAPTOJANIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CIS TRANS ISOMERISM; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; ENZYME LOCALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; HUMANS; KINETICS; LIGANDS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE;

EID: 72749093773     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9012462     Document Type: Article

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