메뉴 건너뛰기




Volumn 65, Issue 4, 2011, Pages 252-259

Possible role of peritoneal NF-κB in peripheral inflammation and cancer: Lessons from the inhibitor DHMEQ

Author keywords

DHMEQ; NF B; Peritoneal cavity

Indexed keywords

ANTIINFLAMMATORY AGENT; APOLIPOPROTEIN; B RAF KINASE; BORTEZOMIB; CD24 ANTIGEN; CD44V ANTIGEN; CELL SURFACE RECEPTOR; CYSTEINE; DEHYDROXYMETHYLEPOXYQUINOMICIN; GRANULOCYTE COLONY STIMULATING FACTOR; HISTAMINE; HISTAMINE DECARBOXYLASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LATENT MEMBRANE PROTEIN 1; OSTEOCLAST DIFFERENTIATION FACTOR; PANEPOXYDONE; PARIETAL CELL ANTIBODY; PHYTOHEMAGGLUTININ; TAX PROTEIN; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT C1; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

EID: 79960390177     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2011.02.003     Document Type: Review
Times cited : (40)

References (55)
  • 1
    • 4544228457 scopus 로고    scopus 로고
    • Functions of NF-κB1 and NF-κB2 in immune cell biology
    • Sören B., Sten C. Functions of NF-κB1 and NF-κB2 in immune cell biology. Biochem J 2004, 382:393-409.
    • (2004) Biochem J , vol.382 , pp. 393-409
    • Sören, B.1    Sten, C.2
  • 2
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • Li Q., Verma I.M. NF-κB regulation in the immune system. Nat Rev Immunol 2002, 2:331-367.
    • (2002) Nat Rev Immunol , vol.2 , pp. 331-367
    • Li, Q.1    Verma, I.M.2
  • 3
    • 73649122793 scopus 로고    scopus 로고
    • Chemical biology of inflammatory cytokine signaling
    • Kataoka T. Chemical biology of inflammatory cytokine signaling. J Antibiot (Tokyo) 2009, 62:655-667.
    • (2009) J Antibiot (Tokyo) , vol.62 , pp. 655-667
    • Kataoka, T.1
  • 4
    • 33947714617 scopus 로고    scopus 로고
    • NF-kappaB and cytokines
    • Kulms D., Schwarz T. NF-kappaB and cytokines. Vitam Horm 2006, 74:283-300.
    • (2006) Vitam Horm , vol.74 , pp. 283-300
    • Kulms, D.1    Schwarz, T.2
  • 6
  • 7
    • 0031782069 scopus 로고    scopus 로고
    • Cycloepoxydon: 1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene1-hydroxy-2-hydroxymethyl-3-pent-1, 3-dienylbenzene, new inhibitors of eukaryotic signal transduction
    • Gehrt A., Erkel G., Anke T., Sterner O.A. Cycloepoxydon: 1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene1-hydroxy-2-hydroxymethyl-3-pent-1, 3-dienylbenzene, new inhibitors of eukaryotic signal transduction. J Antibiot 1998, 51:455-463.
    • (1998) J Antibiot , vol.51 , pp. 455-463
    • Gehrt, A.1    Erkel, G.2    Anke, T.3    Sterner, O.A.4
  • 8
    • 3242671837 scopus 로고    scopus 로고
    • Preparation and biological activities of optically active dehydroxymethylepoxyquinomicin, a novel NF-κB inhibitor
    • Suzuki Y., Sugiyama C., Ohno O., Umezawa K. Preparation and biological activities of optically active dehydroxymethylepoxyquinomicin, a novel NF-κB inhibitor. Tetrahedron 2004, 60:7061-7066.
    • (2004) Tetrahedron , vol.60 , pp. 7061-7066
    • Suzuki, Y.1    Sugiyama, C.2    Ohno, O.3    Umezawa, K.4
  • 9
    • 33748326108 scopus 로고    scopus 로고
    • Inhibition of TNF-α-induced nuclear translocation and activation of NF-κB by dehydroxymethyl-epoxyquinomicin
    • Ariga A., Namekawa J., Matsumoto N., Inoue J., Umezawa K. Inhibition of TNF-α-induced nuclear translocation and activation of NF-κB by dehydroxymethyl-epoxyquinomicin. J Biol Chem 2002, 277:27625-27630.
    • (2002) J Biol Chem , vol.277 , pp. 27625-27630
    • Ariga, A.1    Namekawa, J.2    Matsumoto, N.3    Inoue, J.4    Umezawa, K.5
  • 10
    • 52449131840 scopus 로고    scopus 로고
    • Inactivation of nuclear factor kappa B components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues
    • Yamamoto M., Horie R., Takeiri M., Kozawa I., Umezawa K. Inactivation of nuclear factor kappa B components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues. J Med Chem 2008, 51:5780-5788.
    • (2008) J Med Chem , vol.51 , pp. 5780-5788
    • Yamamoto, M.1    Horie, R.2    Takeiri, M.3    Kozawa, I.4    Umezawa, K.5
  • 11
    • 68949090105 scopus 로고    scopus 로고
    • Unusual intramolecular N→O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine
    • Kozawa I., Kato K., Teruya T., Suenaga K., Umezawa K. Unusual intramolecular N→O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine. Bioorg Med Chem Lett 2009, 19:5380-5382.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 5380-5382
    • Kozawa, I.1    Kato, K.2    Teruya, T.3    Suenaga, K.4    Umezawa, K.5
  • 12
    • 33748294546 scopus 로고    scopus 로고
    • Inhibition of macrophage activation and phagocytosis by a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin
    • Suzuki E., Umezawa K. Inhibition of macrophage activation and phagocytosis by a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin. Biomed Pharmacother 2006, 60:578-586.
    • (2006) Biomed Pharmacother , vol.60 , pp. 578-586
    • Suzuki, E.1    Umezawa, K.2
  • 13
    • 67650803168 scopus 로고    scopus 로고
    • Inhibition of inflammatory mediator secretion by (-)-DHMEQ in mouse bone marrow-derived macrophages
    • Suzuki E., Sugiyama C., Umezawa K. Inhibition of inflammatory mediator secretion by (-)-DHMEQ in mouse bone marrow-derived macrophages. Biomed Pharmacother 2009, 63:351-358.
    • (2009) Biomed Pharmacother , vol.63 , pp. 351-358
    • Suzuki, E.1    Sugiyama, C.2    Umezawa, K.3
  • 14
    • 58149497007 scopus 로고    scopus 로고
    • Induction of hisitidine decarboxylase in macrophages inhibited by the novel NF-kappa B inhibitor (-)-DHMEQ
    • Suzuki E., Ninomiya Y., Umezawa K. Induction of hisitidine decarboxylase in macrophages inhibited by the novel NF-kappa B inhibitor (-)-DHMEQ. Biochem Biophys Res Commun 2009, 379:379-383.
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 379-383
    • Suzuki, E.1    Ninomiya, Y.2    Umezawa, K.3
  • 15
    • 20144373896 scopus 로고    scopus 로고
    • Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1
    • Takatsuna H., Asagiri M., Kubota T., Oka K., Osada T., Sugiyama C., et al. Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1. J Bone Mineral Res 2005, 20:653-661.
    • (2005) J Bone Mineral Res , vol.20 , pp. 653-661
    • Takatsuna, H.1    Asagiri, M.2    Kubota, T.3    Oka, K.4    Osada, T.5    Sugiyama, C.6
  • 16
    • 33846031926 scopus 로고    scopus 로고
    • The molecular understanding of osteoclast differentiation
    • Asagiri M., Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 2007, 40:251-264.
    • (2007) Bone , vol.40 , pp. 251-264
    • Asagiri, M.1    Takayanagi, H.2
  • 17
    • 35948958589 scopus 로고    scopus 로고
    • NF-κB inhibitor DHMEQ suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANCL OPG or M-CSF
    • Kubota T., Hoshino M., Aoki K., Ohya K., Komano Y., Nanki T., et al. NF-κB inhibitor DHMEQ suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANCL OPG or M-CSF. Arthritis Res Ther 2007, 9:R97.
    • (2007) Arthritis Res Ther , vol.9
    • Kubota, T.1    Hoshino, M.2    Aoki, K.3    Ohya, K.4    Komano, Y.5    Nanki, T.6
  • 18
    • 33644671435 scopus 로고    scopus 로고
    • Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells
    • Wakamatsu K., Nanki T., Miyasaka N., Umezawa K., Kubota T. Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells. Arthritis Res Ther 2003, 7:1348-1359.
    • (2003) Arthritis Res Ther , vol.7 , pp. 1348-1359
    • Wakamatsu, K.1    Nanki, T.2    Miyasaka, N.3    Umezawa, K.4    Kubota, T.5
  • 19
    • 0037376397 scopus 로고    scopus 로고
    • Novel NF-κB activation inhibitor prevents inflammatory injury in unilateral urethral obstruction
    • Miyajima A., Kosaka T., Seta K., Asano T., Umezawa K., Hayakawa M. Novel NF-κB activation inhibitor prevents inflammatory injury in unilateral urethral obstruction. J Urol 2003, 169:1559-1563.
    • (2003) J Urol , vol.169 , pp. 1559-1563
    • Miyajima, A.1    Kosaka, T.2    Seta, K.3    Asano, T.4    Umezawa, K.5    Hayakawa, M.6
  • 20
    • 48649096672 scopus 로고    scopus 로고
    • The novel NF-κB activation inhibitor dehydroxymethyl-epoxyquinomicin suppresses anti-Thy1.1-induced glomerulonephritis in rats
    • Kosaka T., Miyajima A., Kikuchi E., Horiguchi Y., Umezawa K., Ohigashi T., et al. The novel NF-κB activation inhibitor dehydroxymethyl-epoxyquinomicin suppresses anti-Thy1.1-induced glomerulonephritis in rats. Nephron Exp Nephrol 2008, 110:e17-e24.
    • (2008) Nephron Exp Nephrol , vol.110
    • Kosaka, T.1    Miyajima, A.2    Kikuchi, E.3    Horiguchi, Y.4    Umezawa, K.5    Ohigashi, T.6
  • 21
    • 23044483988 scopus 로고    scopus 로고
    • Prevention of cancer cachexia by a novel nuclear factor κB inhibitor in prostate cancer
    • Kuroda K., Horiguchi Y., Nakashima J., Kikuchi E., Kanao K., Miyajima A., et al. Prevention of cancer cachexia by a novel nuclear factor κB inhibitor in prostate cancer. Clin Cancer Res 2005, 11:5590-5594.
    • (2005) Clin Cancer Res , vol.11 , pp. 5590-5594
    • Kuroda, K.1    Horiguchi, Y.2    Nakashima, J.3    Kikuchi, E.4    Kanao, K.5    Miyajima, A.6
  • 23
    • 48949096764 scopus 로고    scopus 로고
    • The novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reperfusion in rats
    • Suzuki T., Yamashita K., Jomen W., Ueki S., Aoyagi T., Fukai M., et al. The novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reperfusion in rats. J Surg Res 2008, 149:69-75.
    • (2008) J Surg Res , vol.149 , pp. 69-75
    • Suzuki, T.1    Yamashita, K.2    Jomen, W.3    Ueki, S.4    Aoyagi, T.5    Fukai, M.6
  • 24
    • 35148898712 scopus 로고    scopus 로고
    • Suppression of diabetes-induced retinal inflammation by blocking angiotensin II type 1 receptor or its downstream NF-κB pathway
    • Nagai N., Oike Y., Izumi-Nagai K., Koto T., Satofuka S., Ozawa Y., et al. Suppression of diabetes-induced retinal inflammation by blocking angiotensin II type 1 receptor or its downstream NF-κB pathway. Invest Ophthalmol Vis Sci 2007, 48:4342-4350.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 4342-4350
    • Nagai, N.1    Oike, Y.2    Izumi-Nagai, K.3    Koto, T.4    Satofuka, S.5    Ozawa, Y.6
  • 25
    • 77951227605 scopus 로고    scopus 로고
    • Nuclear factor-κB inhibitor, dehydroxy methyl epoxyquinomicin ameliorates experimental autoimmune uveoreitnitis (EAU) in mice
    • Iwata D., Kitaichi N., Ebihara A., Iwabuchi K., Yoshida K., Namba K., et al. Nuclear factor-κB inhibitor, dehydroxy methyl epoxyquinomicin ameliorates experimental autoimmune uveoreitnitis (EAU) in mice. Invest Ophthalmol Vis Sci 2010, 51:2077-2084.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 2077-2084
    • Iwata, D.1    Kitaichi, N.2    Ebihara, A.3    Iwabuchi, K.4    Yoshida, K.5    Namba, K.6
  • 26
    • 33845947853 scopus 로고    scopus 로고
    • Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin
    • Ueki S., Yamashita K., Aoyagi T., Haga S., Suzuki T., Itoh T., et al. Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin. Transplantation 2006, 82:1720-1727.
    • (2006) Transplantation , vol.82 , pp. 1720-1727
    • Ueki, S.1    Yamashita, K.2    Aoyagi, T.3    Haga, S.4    Suzuki, T.5    Itoh, T.6
  • 27
    • 43749120230 scopus 로고    scopus 로고
    • DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells
    • Nishioka C., Ikezoe T., Jing Y., Umezawa K., Yokoyama A. DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells. Immunology 2008, 124:198-205.
    • (2008) Immunology , vol.124 , pp. 198-205
    • Nishioka, C.1    Ikezoe, T.2    Jing, Y.3    Umezawa, K.4    Yokoyama, A.5
  • 29
    • 4644324186 scopus 로고    scopus 로고
    • NF-κB functions as a tumour promoter in inflammation-associated cancer
    • Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 2004, 431:461-466.
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 30
    • 12944273470 scopus 로고    scopus 로고
    • Targeting of NF-κB pathways by DHMEQ, a novel inhibitor of breast carcinomas: Anti-tumor and anti-angiogenic activity in vivo
    • Matsumoto G., Namekawa J., Muta M., Nakamura T., Bando H., Tohyama K., et al. Targeting of NF-κB pathways by DHMEQ, a novel inhibitor of breast carcinomas: Anti-tumor and anti-angiogenic activity in vivo. Clin Cancer Res 2005, 11:1287-1293.
    • (2005) Clin Cancer Res , vol.11 , pp. 1287-1293
    • Matsumoto, G.1    Namekawa, J.2    Muta, M.3    Nakamura, T.4    Bando, H.5    Tohyama, K.6
  • 31
    • 0037227989 scopus 로고    scopus 로고
    • Suppression of hormone-refractory prostate cancer by a novel nuclear factor κB inhibitor in nude mice
    • Kikuchi E., Horiguchi Y., Nakashima J., Kuroda K., Oya M., Ohigashi T., et al. Suppression of hormone-refractory prostate cancer by a novel nuclear factor κB inhibitor in nude mice. Cancer Res 2003, 63:107-110.
    • (2003) Cancer Res , vol.63 , pp. 107-110
    • Kikuchi, E.1    Horiguchi, Y.2    Nakashima, J.3    Kuroda, K.4    Oya, M.5    Ohigashi, T.6
  • 32
    • 77950300277 scopus 로고    scopus 로고
    • Potent cytotoxic effect of a novel nuclear factor-kappa B inhibitor DHMEQ on human bladder cancer cells producing various cytokines
    • Kodaira K., Kikuchi E., Kosugi M., Horiguchi Y., Matsumoto K., Kanai K., et al. Potent cytotoxic effect of a novel nuclear factor-kappa B inhibitor DHMEQ on human bladder cancer cells producing various cytokines. Urology 2010, 75:805-812.
    • (2010) Urology , vol.75 , pp. 805-812
    • Kodaira, K.1    Kikuchi, E.2    Kosugi, M.3    Horiguchi, Y.4    Matsumoto, K.5    Kanai, K.6
  • 33
    • 6044271614 scopus 로고    scopus 로고
    • Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, DHMEQ
    • Starenki D.V., Namba H., Saenko V.A., Ohtsuru A., Maeda S., Umezawa K., et al. Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, DHMEQ. Clin Cancer Res 2004, 10:6821-6829.
    • (2004) Clin Cancer Res , vol.10 , pp. 6821-6829
    • Starenki, D.V.1    Namba, H.2    Saenko, V.A.3    Ohtsuru, A.4    Maeda, S.5    Umezawa, K.6
  • 34
    • 33751549248 scopus 로고    scopus 로고
    • BRAFV600E promotes invasiveness of thyroid cancer cells through NF-κB activation
    • Palona I., Namba H., Mitsutake N., Starenki D., Podtcheko A., Sedliarou I., et al. BRAFV600E promotes invasiveness of thyroid cancer cells through NF-κB activation. Endocrinology 2006, 147:5699-5707.
    • (2006) Endocrinology , vol.147 , pp. 5699-5707
    • Palona, I.1    Namba, H.2    Mitsutake, N.3    Starenki, D.4    Podtcheko, A.5    Sedliarou, I.6
  • 35
    • 33644644326 scopus 로고    scopus 로고
    • Enhancement of the caspase-independent apoptotic sensitivity of pancreatic cancer cells by DHMEQ, an NF-κB inhibitor
    • Matsumoto G., Muta M., Umezawa K., dxSuzuki T., Mitsumi K., Tsuruta K., et al. Enhancement of the caspase-independent apoptotic sensitivity of pancreatic cancer cells by DHMEQ, an NF-κB inhibitor. Int J Oncol 2005, 27:1247-1255.
    • (2005) Int J Oncol , vol.27 , pp. 1247-1255
    • Matsumoto, G.1    Muta, M.2    Umezawa, K.3    dxSuzuki, T.4    Mitsumi, K.5    Tsuruta, K.6
  • 36
    • 27144476790 scopus 로고    scopus 로고
    • Dual targeting of transformed and untransformed HTLV-1-infected T-cells by DHMEQ, a potent and selective inhibitor of NF-κB, as a strategy for chemoprevention and therapy of adult T cell leukemia
    • Watanabe M., Ohsugi T., Shoda M., Ishida T., Aizawa S., Maruyama-Nagai M., et al. Dual targeting of transformed and untransformed HTLV-1-infected T-cells by DHMEQ, a potent and selective inhibitor of NF-κB, as a strategy for chemoprevention and therapy of adult T cell leukemia. Blood 2005, 106:2462-2471.
    • (2005) Blood , vol.106 , pp. 2462-2471
    • Watanabe, M.1    Ohsugi, T.2    Shoda, M.3    Ishida, T.4    Aizawa, S.5    Maruyama-Nagai, M.6
  • 37
    • 24944487318 scopus 로고    scopus 로고
    • In vivo antitumor activity of the NF-κB inhibitor dehydroxymethyl-epoxyquinomicin in a mouse model of adult T-cell leukemia
    • Ohsugi T., Horie R., Kumasaka T., Ishida A., Ishida T., Yamaguchi K., et al. In vivo antitumor activity of the NF-κB inhibitor dehydroxymethyl-epoxyquinomicin in a mouse model of adult T-cell leukemia. Carcinogenesis 2005, 26:1382-1388.
    • (2005) Carcinogenesis , vol.26 , pp. 1382-1388
    • Ohsugi, T.1    Horie, R.2    Kumasaka, T.3    Ishida, A.4    Ishida, T.5    Yamaguchi, K.6
  • 38
    • 35148844816 scopus 로고    scopus 로고
    • Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult T-cell leukemia-derived cell lines
    • Ohsugi T., Kumasaka T., Okada S., Ishida T., Yamaguchi K., Horie R., et al. Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult T-cell leukemia-derived cell lines. Cancer Lett 2007, 257:206-215.
    • (2007) Cancer Lett , vol.257 , pp. 206-215
    • Ohsugi, T.1    Kumasaka, T.2    Okada, S.3    Ishida, T.4    Yamaguchi, K.5    Horie, R.6
  • 39
    • 13244252299 scopus 로고    scopus 로고
    • A novel NF-κB inhibitor DHMEQ selectively targets constitutive NF-κB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo
    • Watanabe M., Dewan M.Z., Okamura T., Sasaki M., Itoh K., Higashihara M., et al. A novel NF-κB inhibitor DHMEQ selectively targets constitutive NF-κB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo. Int J Cancer 2005, 114:32-38.
    • (2005) Int J Cancer , vol.114 , pp. 32-38
    • Watanabe, M.1    Dewan, M.Z.2    Okamura, T.3    Sasaki, M.4    Itoh, K.5    Higashihara, M.6
  • 40
    • 2342667387 scopus 로고    scopus 로고
    • The development of proteasome inhibitors as anticancer drugs
    • Adams J. The development of proteasome inhibitors as anticancer drugs. Cancer Cell 2005, 5:417-421.
    • (2005) Cancer Cell , vol.5 , pp. 417-421
    • Adams, J.1
  • 41
    • 23144462040 scopus 로고    scopus 로고
    • A novel nuclear factor kappa B inhibitor induced apoptosis of multiple myeloma cells
    • Tatetsu H., Okuno Y., Nakamura M., Matsuno F., Sonoki T., Taniguchi I., et al. A novel nuclear factor kappa B inhibitor induced apoptosis of multiple myeloma cells. Mol Cancer Ther 2005, 4:1114-1120.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1114-1120
    • Tatetsu, H.1    Okuno, Y.2    Nakamura, M.3    Matsuno, F.4    Sonoki, T.5    Taniguchi, I.6
  • 42
    • 33947526496 scopus 로고    scopus 로고
    • IκBα independent induction of NF-κB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells
    • Watanabe M., Dewan M.Z., Taira M., Shoda M., Honda M., Sata T., et al. IκBα independent induction of NF-κB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells. Lab Invest 2007, 87:372-382.
    • (2007) Lab Invest , vol.87 , pp. 372-382
    • Watanabe, M.1    Dewan, M.Z.2    Taira, M.3    Shoda, M.4    Honda, M.5    Sata, T.6
  • 43
    • 0347719385 scopus 로고    scopus 로고
    • Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation
    • Luftig M., Yasui T., Soni V., Kang M.S., Jacobson N., Cahir-McFarland E., et al. Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. Proc Natl Acad Sci U S A 2004, 6:141-146.
    • (2004) Proc Natl Acad Sci U S A , vol.6 , pp. 141-146
    • Luftig, M.1    Yasui, T.2    Soni, V.3    Kang, M.S.4    Jacobson, N.5    Cahir-McFarland, E.6
  • 44
    • 45849151698 scopus 로고    scopus 로고
    • Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-κB inhibitor DHMEQ
    • Miyake A., Dewan Z., Ishida T., Watanabe M., Honda M., Sata T., et al. Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-κB inhibitor DHMEQ. Microbes Infect 2008, 10:748-756.
    • (2008) Microbes Infect , vol.10 , pp. 748-756
    • Miyake, A.1    Dewan, Z.2    Ishida, T.3    Watanabe, M.4    Honda, M.5    Sata, T.6
  • 45
    • 67449103166 scopus 로고    scopus 로고
    • Transient inhibition of NF-κB by DHMEQ induces cell death of primary effusion lymphoma without HHV-8 reactivation
    • Dabaghmanesh N., Matsubara A., Miyake A., Nakano K., Ishida T., Katano H., et al. Transient inhibition of NF-κB by DHMEQ induces cell death of primary effusion lymphoma without HHV-8 reactivation. Cancer Sci 2009, 100:737-746.
    • (2009) Cancer Sci , vol.100 , pp. 737-746
    • Dabaghmanesh, N.1    Matsubara, A.2    Miyake, A.3    Nakano, K.4    Ishida, T.5    Katano, H.6
  • 46
    • 74249088301 scopus 로고    scopus 로고
    • Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells
    • Murohashi M., Hinohara K., Kuroda M., Isagawa T., Tsuji S., Kobayashi S., et al. Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells. Br J Cancer 2010, 102:206-212.
    • (2010) Br J Cancer , vol.102 , pp. 206-212
    • Murohashi, M.1    Hinohara, K.2    Kuroda, M.3    Isagawa, T.4    Tsuji, S.5    Kobayashi, S.6
  • 47
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., Werb Z. Inflammation and cancer. Nature 2003, 420:860-867.
    • (2003) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 48
    • 33748311907 scopus 로고    scopus 로고
    • Inhibition of tumor growth by NF-κB inhibitors
    • Umezawa K. Inhibition of tumor growth by NF-κB inhibitors. Cancer Sci 2006, 97:990-995.
    • (2006) Cancer Sci , vol.97 , pp. 990-995
    • Umezawa, K.1
  • 49
    • 48049124544 scopus 로고    scopus 로고
    • A simple and reliable method for determining plasma concentration of dehydroxymethylepoxyquinomicin by high performance liquid chromatography with mass spectrometry
    • Watanabe E., Mochizuki N., Ajima H., Ohno K., Shiino M., Umezawa K., et al. A simple and reliable method for determining plasma concentration of dehydroxymethylepoxyquinomicin by high performance liquid chromatography with mass spectrometry. J. Chromatogr B 2008, 871:32-36.
    • (2008) J. Chromatogr B , vol.871 , pp. 32-36
    • Watanabe, E.1    Mochizuki, N.2    Ajima, H.3    Ohno, K.4    Shiino, M.5    Umezawa, K.6
  • 50
    • 77956898095 scopus 로고    scopus 로고
    • Efficient cellular uptake of the novel NF-κB inhibitor (-)-DHMEQ and irreversible inhibition of NF-κB in neoplastic cells
    • Shimada C., Ninomiya Y., Suzuki E., Umezawa K. Efficient cellular uptake of the novel NF-κB inhibitor (-)-DHMEQ and irreversible inhibition of NF-κB in neoplastic cells. Oncol Res 2010, 18:529-535.
    • (2010) Oncol Res , vol.18 , pp. 529-535
    • Shimada, C.1    Ninomiya, Y.2    Suzuki, E.3    Umezawa, K.4
  • 52
    • 33846049299 scopus 로고    scopus 로고
    • NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
    • Park B.K., Zhang H., Zeng Q., Dai J., Keller E.T., Giordano T., et al. NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nature Med 2007, 13:62-69.
    • (2007) Nature Med , vol.13 , pp. 62-69
    • Park, B.K.1    Zhang, H.2    Zeng, Q.3    Dai, J.4    Keller, E.T.5    Giordano, T.6
  • 53
    • 33847029227 scopus 로고    scopus 로고
    • Colon cancer cell-derived tumor necrosis factor-α mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway
    • Zins K., Abraham D., Sioud M., Aharinejad S. Colon cancer cell-derived tumor necrosis factor-α mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway. Cancer Res 2007, 67:1038-1045.
    • (2007) Cancer Res , vol.67 , pp. 1038-1045
    • Zins, K.1    Abraham, D.2    Sioud, M.3    Aharinejad, S.4
  • 54
    • 0014693822 scopus 로고
    • Lymphocyte to macrophage transformation in the peritoneal cavity preceding the mobilization of peritoneal macrophages to inflamed areas
    • Vernon-Roberts B. Lymphocyte to macrophage transformation in the peritoneal cavity preceding the mobilization of peritoneal macrophages to inflamed areas. Nature 1969, 222:1286-1288.
    • (1969) Nature , vol.222 , pp. 1286-1288
    • Vernon-Roberts, B.1
  • 55
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of TH2 cytokines by adipose tissue-associated c-Kit+ Sca-1+ lymphoid cells
    • Moro K., Yamada T., Tanabe M., Takeuchi T., Ikawa T., Kawamoto H., et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+ Sca-1+ lymphoid cells. Nature 2010, 463:540-544.
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1    Yamada, T.2    Tanabe, M.3    Takeuchi, T.4    Ikawa, T.5    Kawamoto, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.