Contribution of Epstein-Barr virus infection to chemoresistance of gastric carcinoma cells to 5-fluorouracil

Archives of Pharmacal Research

Volumn 34, Issue 4, 2011, Pages 635-643

  Seo, Jung Seon ^a   Kim, Tai Gyu ^a   Hong, Young Seon ^a   Chen, Jen Yang ^b   Lee, Suk Kyeong ^a  

^a The Catholic University of Korea   (South Korea)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

5 FU; Apoptosis; Chemoresistance; EBV lytic genes; Epstein Barr virus (EBV); Gastric carcinoma

Indexed keywords

CASPASE 3; FLUOROURACIL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SENSITIVITY; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; IMMUNOFLUORESCENCE; PROTEIN EXPRESSION; STOMACH CARCINOMA; WESTERN BLOTTING;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; EPSTEIN-BARR VIRUS INFECTIONS; FLUOROURACIL; HUMANS; NEOPLASM PROTEINS; STOMACH NEOPLASMS; TIME FACTORS;

EID: 79960388688     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0414-7     Document Type: Article

References (36)

1. Akiba, S., Koriyama, C., Herrera-Goepfert, R., and Eizuru, Y., Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features. Cancer Sci., 99, 195-201 (2008). (Pubitemid 351228470)
2. Altmann, M. and Hammerschmidt, W., Epstein-Barr virus provides a new paradigm: a requirement for the immediate inhibition of apoptosis. PLoS Biol., 3, e404 (2005).
3. Bellows, D. S., Howell, M., Pearson, C., Hazlewood, S. A., and Hardwick, J. M., Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins. J. Virol., 76, 2469-2479 (2002). (Pubitemid 34150715)
4. Cabras, G., Decaussin, G., Zeng, Y., Djennaoui, D., Melouli, H., Broully, P., Bouguermouh, A. M., and Ooka, T., Epstein-Barr virus encoded BALF1 gene is transcribed in Burkitt's lymphoma cell lines and in nasopharyngeal carcinoma's biopsies. J. Clin. Virol., 34, 26-34 (2005). (Pubitemid 41125873)
5. Cayrol, C. and Flemington, E. K., The Epstein-Barr virus bZIP transcription factor Zta causes G0/G1 cell cycle arrest through induction of cyclin-dependent kinase inhibitors. EMBO J., 15, 2748-2759 (1996).
6. Chong, J. M., Fukayama, M., Hayashi, Y., Takizawa, T., Koike, M., Konishi, M., Kikuchi-Yanoshita, R., and Miyaki, M., Microsatellite instability in the progression of gastric carcinoma. Cancer Res., 54, 4595-4597 (1994). (Pubitemid 24276478)
7. Chou, S. P., Tsai, C. H., Li, L. Y., Liu, M. Y., and Chen, J. Y., Characterization of monoclonal antibody to the Epstein-Barr virus BHRF1 protein, a homologue of Bcl-2. Hybrid Hybridomics, 23, 29-37 (2004).
8. Desbien, A. L., Kappler, J. W., and Marrack, P., The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim. Proc. Natl. Acad. Sci. U. S. A., 106, 5663-5668 (2009).
9. Dreyfus, D. H., Nagasawa, M., Kelleher, C. A., and Gelfand, E. W., Stable expression of Epstein-Barr virus BZLF-1-encoded ZEBRA protein activates p53-dependent transcription in human Jurkat T-lymphoblastoid cells. Blood, 96, 625-634 (2000). (Pubitemid 30463384)
10. Feng, W. H., Israel, B., Raab-Traub, N., Busson, P., and Kenney, S. C., Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Res., 62, 1920-1926 (2002). (Pubitemid 34408523)
11. Feuillard, J., Schuhmacher, M., Kohanna, S., Asso-Bonnet, M., Ledeur, F., Joubert-Caron, R., Bissières, P., Polack, A., Bornkamm, G. W., and Raphaël, M., Inducible loss of NF-kappaB activity is associated with apoptosis and Bcl-2 down-regulation in Epstein-Barr virus-transformed B lymphocytes. Blood, 95, 2068-2075 (2000). (Pubitemid 30151647)
12. Fukayama, M., Hayashi, Y., Iwasaki, Y., Chong, J., Ooba, T., Takizawa, T., Koike, M., Mizutani, S., Miyaki, M., and Hirai, K., Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab. Invest., 71, 73-81 (1994). (Pubitemid 24246024)
13. Henderson, S., Rowe, M., Gregory, C., Croom-Carter, D., Wang, F., Longnecker, R., Kieff, E., and Rickinson, A., Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell, 65, 1107-1115 (1991). (Pubitemid 121001325)
14. Hickish, T., Robertson, D., Clarke, P., Hill, M., di Stefano, F., Clarke, C., and Cunningham, D., Ultrastructural localization of BHRF1: an Epstein-Barr virus gene product which has homology with bcl-2. Cancer Res., 54, 2808-2811 (1994). (Pubitemid 24173779)
15. Hino, R., Uozaki, H., Inoue, Y., Shintani, Y., Ushiku, T., Sakatani, T., Takada, K., and Fukayama, M., Survival advantage of EBV-associated gastric carcinoma: survivin up-regulation by viral latent membrane protein 2A. Cancer Res., 68, 1427-1435 (2008). (Pubitemid 351346850)
16. Imai, S., Koizumi, S., Sugiura, M., Tokunaga, M., Uemura, Y., Yamamoto, N., Tanaka, S., Sato, E., and Osato, T., Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc. Natl. Acad. Sci. U. S. A., 91, 9131-9135 (1994).
17. Inoue, Y., Tanaka, K., Hiro, J., Yoshiyama, S., Toiyama, Y., Eguchi, T., Miki, C., and Kusunoki, M., in vitro synergistic antitumor activity of a combination of 5-fluorouracil and irinotecan in human colon cancer. Int. J. Oncol., 28, 479-486 (2006).
18. Jung, E. J., Lee, Y. M., Lee, B. L., Chang, M. S., and Kim, W. H., Ganciclovir augments the lytic induction and apoptosis induced by chemotherapeutic agents in an Epstein-Barr virus-infected gastric carcinoma cell line. Anticancer Drugs, 18, 79-85 (2007).
19. Kieff, E., Epstein-Barr Virus and its replication. In Fields, B., Knipe, D., and Howley, P. (Eds.). Fields Virology. Lippincott-Raven Publishers, Philadelphia, pp. 2343-2396, (1996).
20. Komano, J., Maruo, S., Kurozumi, K., Oda, T., and Takada, K., Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata. J. Virol., 73, 9827-9831 (1999).
21. Kume, T., Oshima, K., Shinohara, T., Takeo, H., Yamashita, Y., Shirakusa, T., and Kikuchi, M., Low rate of apoptosis and overexpression of bcl-2 in Epstein-Barr virus-associated gastric carcinoma. Histopathology, 34, 502-509 (1999). (Pubitemid 29284624)
22. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E., p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967 (1993). (Pubitemid 23289454)
23. Marshall, W. L., Yim, C., Gustafson, E., Graf, T., Sage, D. R., Hanify, K., Williams, L., Fingeroth, J., and Finberg, R. W., Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak. J. Virol., 73, 5181-5185 (1999). (Pubitemid 29246784)
24. Nishikawa, J., Imai, S., Oda, T., Kojima, T., Okita, K., and Takada, K., Epstein-Barr virus promotes epithelial cell growth in the absence of EBNA2 and LMP1 expression. J. Virol., 73, 1286-1292 (1999). (Pubitemid 29036783)
25. Nita, M. E., Nagawa, H., Tominaga, O., Tsuno, N., Fujii, S., Sasaki, S., Fu, C. G., Takenoue, T., Tsuruo, T., and Muto, T., 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. Br. J. Cancer, 78, 986-992 (1998). (Pubitemid 28463972)
26. Peters, G. J. and van Groeningen, C. J., Clinical relevance of biochemical modulation of 5-fluorouracil. Ann. Oncol., 2, 469-480 (1991).
27. Rowe, M., Peng-Pilon, M., Huen, D. S., Hardy, R., Croom-Carter, D., Lundgren, E., and Rickinson, A. B., Upregula-tion of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers. J. Virol., 68, 5602-5612 (1994). (Pubitemid 24258573)
28. Sato, Y., Shirata, N., Kudoh, A., Iwahori, S., Nakayama, S., Murata, T., Isomura, H., Nishiyama, Y., and Tsurumi, T., Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription. Virology, 388, 204-211 (2009).
29. Shimizu, N., Yoshiyama, H., and Takada, K., Clonal propagation of Epstein-Barr virus (EBV) recombinants in EBV-negative Akata cells. J. Virol., 70, 7260-7263 (1996). (Pubitemid 26307449)
30. Sugiura, M., Imai, S., Tokunaga, M., Koizumi, S., Uchizawa, M., Okamoto, K., and Osato, T., Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells. Br. J. Cancer, 74, 625-631 (1996). (Pubitemid 26279061)
31. Tarodi, B., Subramanian, T., and Chinnadurai, G., Epstein-Barr virus BHRF1 protein protects against cell death induced by DNA-damaging agents and heterologous viral infection. Virology, 201, 404-407 (1994). (Pubitemid 24187289)
32. Uozaki, H. and Fukayama, M., Epstein-Barr virus and gastric carcinoma-viral carcinogenesis through epigenetic mechanisms. Int. J. Clin. Exp. Pathol., 1, 198-216 (2008).
33. Yoshiyama, H., Imai, S., Shimizu, N., and Takada, K., Epstein-Barr virus infection of human gastric carcinoma cells: implication of the existence of a new virus receptor different from CD21. J. Virol., 71, 5688-5691 (1997). (Pubitemid 27258255)
34. Zhang, Q., Gutsch, D., and Kenney, S., Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency. Mol. Cell. Biol., 14, 1929-1938 (1994). (Pubitemid 24074588)
35. zur Hausen, A., Brink, A. A., Craanen, M. E., Middeldorp, J. M., Meijer, C. J., and van den Brule, A. J., Unique transcription pattern of Epstein-Barr virus (EBV) in EBV-carrying gastric adenocarcinomas: expression of the transforming BARF1 gene. Cancer Res., 60, 2745-2748 (2000). (Pubitemid 30318253)
36. zur Hausen, A., van Grieken, N. C., Meijer, G. A., Hermsen, M. A., Bloemena, E., Meuwissen, S. G., Baak, J. P., Meijer, C. J., Kuipers, E. J., and van den Brule, A. J., Distinct chromosomal aberrations in Epstein-Barr virus-carrying gastric carcinomas tested by comparative genomic hybridization. Gastroenterology, 121, 612-618 (2001). (Pubitemid 32822576)