Ganciclovir augments the lytic induction and apoptosis induced by chemotherapeutic agents in an Epstein-Barr virus-infected gastric carcinoma cell line

Anti-Cancer Drugs

Volumn 18, Issue 1, 2007, Pages 79-85

  Ji Jung, Eun ^a   Mie Lee, You ^a,b   Lan Lee, Byung ^a   Soo Chang, Mee ^a   Ho Kim, Woo ^a  

^a Seoul National University   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

Apoptosis; Chemotherapy; Ganciclovir; Human herpesvirus 4; Stomach neoplasms

Indexed keywords

ANTINEOPLASTIC AGENT; BMRF1 PROTEIN; BRLF1 PROTEIN; CISPLATIN; FLUOROURACIL; GANCICLOVIR; IMMEDIATE EARLY PROTEIN BZLF1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE C DELTA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL STRAIN SNU 719; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOLYSIS; DRUG EFFICACY; DRUG POTENTIATION; DRUG TARGETING; EPITHELIUM CELL; EPSTEIN BARR VIRUS; HERPES VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; TUMOR CELL; TUMOR VIRUS;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DRUG SYNERGISM; FLUOROURACIL; GANCICLOVIR; HERPESVIRUS 4, HUMAN; HUMANS; PACLITAXEL; STOMACH NEOPLASMS;

EID: 33845608377     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e3280101006     Document Type: Article

References (19)

1. Kieff E. Epstein-Barr virus and its replication. In: Knipe D, Howley P, editors. Fields virology. 4th ed. Philadelphia: Lippincott-Raven; 2001. pp. 2511-2627.
2. Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, et al. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 1984; 310:207-211.
3. Luo B, Wang Y, Wang XF, Liang H, Yan LP, Huang BH, et al. Expression of Epstein-Barr virus genes in EBV-associated gastric carcinomas. World J Gastroenterol 2005; 11:629-633.
4. Israel BF, Kenney SC. Virally targeted therapies for EBV-associated malignancies. Oncogene 2003; 22:5122-5130.
5. Feng WH, Hong G, Deleciuse HJ, Kenney SC. Lytic induction therapy for Epstein-Barr virus-positive B-cell lymphomas. J Virol 2004; 78:1893-1902.
6. Feng WH, Israel B, Raab-Traub N, Busson P, Kenney SC. Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Res 2002; 62:1920-1926.
7. Oh ST, Seo JS, Moon UY, Kang KH, Shin DJ, Yoon SK, et al. A naturally derived gastric cancer cell line shows latency I Epstein-Barr virus infection closely resembling EBV-associated gastric cancer. Virology 2004; 320:330-336.
8. Ohtsu A. Current status and future prospects of chemotherapy for metastatic gastric cancer: a review. Gastric Cancer 2005; 8:95-102.
9. Leong T. Chemotherapy and radiotherapy in the management of gastric cancer. Curr Opin Gastroenterol 2005; 21:673-678.
10. Lin JC, Smith MC, Pagano JS. Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus. J Virol 1984; 50:50-55.
11. Moore SM, Cannon JS, Tanhehco YC, Hamzeh FM, Ambinder RF. Induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues. Antimicrob Agents Chemother 2001; 45:2082-2091.
12. Connors TA. The choice of prodrugs for gene directed enzyme prodrug therapy of cancer. Gene Therapy 1995; 2:702-709.
13. Chang MS, Lee HS, Jung EJ, Kim CW, Lee BL, Kim WH. Cell-cycle regulators, bcl-2 and NF-kappaB in Epstein-Barr virus-positive gastric carcinomas. Int J Oncol 2005; 27:1265-1272.
14. Jung EJ, Lee YM, Lee BL, Chang MS, Kim WH. Lytic induction and apoptosis of Epstein-Barr virus-associated gastric cancer cell line with epigenetic modifiers and Ganciclovir. Cancer Lett 2006 (in press).
15. Roychowdhury S, Peng R, Baiocchi RA, Bhatt D, Vourganti S, Grecula J, et al. Experimental treatment of Epstein-Barr virus-associated primary central nervous system lymphoma. Cancer Res 2003; 63:965-971.
16. Chang YF, Li LL, Wu CW, Liu TY, Lui WY, P'eng FK, et al. Paclitaxel-induced apoptosis in human gastric carcinoma cell lines. Cancer 1996; 77:14-18.
17. Kim R, Tanabe K, Inoue H, Toge T. Mechanism(s) of antitumor action in protracted infusion of low dose 5-fluorouracil and cisplatin in gastric carcinoma. Int J Oncol 2002; 20:549-555.
18. Shi M, Cai O, Yao L, Mao Y, Ming Y, Ouyang G. Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biol Int 2006; 30:221-226.
19. Tanjoni I, Weinlich R, Della-Casa MS, Clissa PB, Saldanha-Gamma RF, de Freitas MS, et al. Jararhagin, a snake venom metalloproteinase, induces a specialized form of apoptosis (anikis) selective to endothelial cells. Apoptosis 2005; 10:851-861.