Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity

Biochemical Pharmacology

Volumn 82, Issue 4, 2011, Pages 341-349

  Kapuria, Vaibhav ^a,c   Peterson, Luke F ^a   Showalter, H D Hollis ^b   Kirchhoff, Paul D ^b   Talpaz, Moshe ^a   Donato, Nicholas J ^a,d  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

Cross linking; Deubiquitinase; Inhibitor; Ubiquitin activating enzyme

Indexed keywords

3,3' DITHIOBIS(SUCCINIMIDYL PROPIONATE); 4 [4 (5 NITRO FURAN 2 YLMETHYLENE) 3,5 DIOXO PYRAZOLIDIN 1 YL]BENZOICACID ETHYL ESTER; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; JANUS KINASE 2; LIGASE INHIBITOR; PYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANTINEOPLASTIC AGENTS; BENZOIC ACIDS; CROSS-LINKING REAGENTS; ENZYME INHIBITORS; FURANS; HEK293 CELLS; HUMANS; K562 CELLS; PYRAZOLES; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITINATED PROTEINS;

EID: 79960360968     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.05.012     Document Type: Article

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