Rigidized 1-aryl sulfonyl tryptamines: Synthesis and pharmacological evaluation as 5-HT 6 receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 15, 2011, Pages 4577-4580

  Nirogi, Ramakrishna ^a   Dwarampudi, Adireddy ^a,b   Kambhampati, Ramasastry ^a   Bhatta, Venugopalarao ^a   Kota, Laxman ^a   Shinde, Anil ^a   Badange, Rajesh ^a   Jayarajan, Pradeep ^a   Bhyrapuneni, Gopinadh ^a   Dubey, P K ^b  

^a SUVEN LIFE SCIENCES LTD   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

5 HT 6R antagonist; NORT; SAR; Water maze

Indexed keywords

ALKYL GROUP; CARBON; N1 ARYLSULFONYL 3 (4 CHLORO 2,5 DIHYDRO 1H PYRROL 3 YL) 1H INDOLE DERIVATIVE; N1 ARYLSULFONYL 3 (PYRROLIDIN 3 YL) 1H INDOLE DERIVATIVE; N1 BENZENESULFONYL 3 (4 CHLORO 1 METHYL 2,5 DIHYDRO 1H PYRROL 3 YL) 1H INDOLE; SEROTONIN 6 RECEPTOR; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING ASSAY; COGNITION; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MAZE TEST; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; INDOLES; LIGANDS; MALE; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRYPTAMINES;

ANIMALIA;

EID: 79960352440     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.106     Document Type: Article

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