Design, synthesis and antifungal activity of novel triazole derivatives

Chinese Chemical Letters

Volumn 15, Issue 4, 2004, Pages 404-407

  Sheng, Chun Quan ^a   Zhang, Wan Nian ^a   Ji, Hai Tao ^a   Song, Yun Long ^a   Zhang, Min ^a   Zhou, You Jun ^a   Lü, Jia Guo ^a   Zhu, Jü ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal; Synthesis; Triazole

Indexed keywords

FLUCONAZOLE; TRIAZOLE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; HYDROPHOBICITY;

EID: 2342648735     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

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5. K. Richardson, US Patent, 1983, 13, 4404216.
6. In vitro antifungal activity was measured by means of the minimal inhibitory concentrations (MIC) using the serial dilution method with 96-well microtest plates. Test fungal strains were obtained from ATCC. Minimal inhibitory concentrations (MIC) were determined in RPM 1640 medium. The MIC was defined as the lowest concentration which resulted in a culture with turbidity less than or equal to the 80% inhibition, when compared with the growth of the control. Test compounds were dissolved in DMSO, serially diluted in growth medium, inoculated and incubated at 35°C. Growth MIC was determined at 24 hr for Candida species, 72 hr for Cryptococcus neoformans and 7 days for filamentous fungi.