Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells

Journal of Nutritional Biochemistry

Volumn 22, Issue 8, 2011, Pages 777-783

  Sabeva, Nadezhda S ^a   McPhaul, Christopher M ^b   Li, Xiangan ^c   Cory, Theodore J ^a   Feola, David J ^a   Graf, Gregory A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

ABC transporter; Interleukin 1 ; Interleukin 6; LXR; Phytosterol; Tumor necrosis factor

Indexed keywords

22 DEHYDROCHOL; ABC TRANSPORTER A1; ABC TRANSPORTER G1; APOLIPOPROTEIN A1; BRASSICASTEROL; CAMPESTEROL; CHOLESTEROL; CYTOKINE; DEHYDROCHOLIC ACID; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; PHYTOSTEROL; SITOSTEROL; STIGMASTEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; FOAM CELL; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; CHOLESTEROL; FOAM CELLS; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MALE; MICE; MICE, INBRED C57BL; PHYTOSTEROLS; SITOSTEROLS; STIGMASTEROL; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 79960288054     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.07.002     Document Type: Article

References (28)

1. Moghadasian M.H., Frohlich J.J. Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: clinical and experimental evidence. Am J Med 1999, 107:588-594.
2. John S., Sorokin A.V., Thompson P.D Phytosterols and vascular disease. Curr Opin Lipidol 2007, 18:35-40.
3. Patel M.D., Thompson P.D Phytosterols and vascular disease. Atherosclerosis 2006, 186:12-19.
4. Thompson G.R., Grundy S.M. History and development of plant sterol and stanol esters for cholesterol-lowering purposes. Am J Cardiol 2005, 96:3D-9D.
5. Kidambi S., Patel S.B. Sitosterolaemia: pathophysiology, clinical presentation and laboratory diagnosis. J Clin Pathol 2008, 61:588-594.
6. Hui D.Y., Labonte E.D., Howles P.N. Development and physiological regulation of intestinal lipid absorption: III. Intestinal transporters and cholesterol absorption. Am J Physiol 2008, 294:G839-843.
7. Weingartner O., Lutjohann D., Ji S., Weisshoff N., List F., Sudhop T., von Bergmann K., Gertz K., Konig J., et al. Vascular effects of diet supplementation with plant sterols. J Am Coll Cardiol 2008, 51:1553-1561.
8. Windler E., Zyriax B.C., Kuipers F., Linseisen J., Boeing H. Association of plasma phytosterol concentrations with incident coronary heart disease data from the CORA study, a case-control study of coronary artery disease in women. Atherosclerosis 2008.
9. Plat J., Beugels I., Gijbels M.J., de Winther M.P., Mensink R.P. Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols. J Lipid Res 2006, 47:2762-2771.
10. Awad A.B., Begdache L.A., Fink C.S. Effect of sterols and fatty acids on growth and triglyceride accumulation in 3t3-l1 cells. J Nutr Biochem 2000, 11:153-158.
11. Awad A.B., Fink C.S. Phytosterols as anticancer dietary components: evidence and mechanism of action. J Nutr 2000, 130:2127-2130.
12. Bao L., Li Y., Deng S.X., Landry D., Tabas I. Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in acat-competent macrophages. J Biol Chem 2006, 281:33635-33649.
13. Rubis B., Paszel A., Kaczmarek M., Rudzinska M., Jelen H., Rybczynska M. Beneficial or harmful influence of phytosterols on human cells?. Br J Nutr 2008, 1-9.
14. Ho S.S., Pal S. Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells. Atherosclerosis 2005, 182:29-36.
15. Batta A.K., Xu G., Honda A., Miyazaki T., Salen G. Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat. Metabolism: Clin Exp 2006, 55:292-299.
16. Yang C., Yu L., Li W., Xu F., Cohen J.C., Hobbs H.H. Disruption of cholesterol homeostasis by plant sterols. J Clin Invest 2004, 114:813-822.
17. Yang C., McDonald J.G., Patel A., Zhang Y., Umetani M., Xu F., Westover E.J., Covey D.F., Mangelsdorf D.J., et al. Sterol intermediates from cholesterol biosynthetic pathway as liver × receptor ligands. J Biol Chem 2006, 281:27816-27826.
18. Carter B.A., Taylor O.A., Prendergast D.R., Zimmerman T.L., Von Furstenberg R., Moore D.D., Karpen S.J. Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res 2007, 62:301-306.
19. Sabeva N.S., Rouse E.J., Graf G.A. Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. J Biol Chem 2007, 282:22397-22405.
20. Coetzee G.A., Strachan A.F., van der Westhuyzen D.R., Hoppe H.C., Jeenah M.S., de Beer F.C. Serum amyloid A-containing human high density lipoprotein 3: density, size, and apolipoprotein composition. J Biol Chem 1986, 261:9644-9651.
21. Griffin E.E., Ullery J.C., Cox B.E., Jerome W.G. Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells. J Lipid Res 2005, 46:2052-2060.
22. Wilund K.R., Yu L., Xu F., Vega G.L., Grundy S.M., Cohen J.C., Hobbs H.H. No association between plasma levels of plant sterols and atherosclerosis in mice and men. Arteriosclerosis, Thromb Vasc Biol 2004, 24:2326-2332.
23. Cook E.B., Stahl J.L., Lowe L., Chen R., Morgan E., Wilson J., Varro R., Chan A., Graziano F.M., Barney N.P. Simultaneous measurement of six cytokines in a single sample of human tears using microparticle-based flow cytometry: allergics vs. non-allergics. J Immunol Methods 2001, 254:109-118.
24. Chen R., Lowe L., Wilson J.D., Crowther E., Tzeggai K., Bishop J.E., Varro R. Simultaneous quantification of six human cytokines in a single sample using microparticle-based flow cytometric technology. Clin Chem 1999, 45:1693-1694.
25. Hoff H., Zyromski N., Armstrong D., O'Neil J. Aggregation as well as chemical modification of LDL during oxidation is responsible for poor processing in macrophages. J Lipid Res 1993, 34:1919-1929.
26. Rigamonti E., Helin L., Lestavel S., Mutka A.L., Lepore M., Fontaine C., Bouhlel M.A., Bultel S., Fruchart J.C., et al. Liver × receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ Res 2005, 97:682-689.
27. Rigamonti E., Chinetti-Gbaguidi G., Staels B. Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men. Arterioscler Thromb Vasc Biol 2008, 28:1050-1059.
28. Zelcer N., Hong C., Boyadjian R., Tontonoz P. LXR regulates cholesterol uptake through idol-dependent ubiquitination of the LDL receptor. Science 2009, 325:100-104.