Effect of sterols and fatty acids on growth and triglyceride accumulation in 3T3-L1 cells

Journal of Nutritional Biochemistry

Volumn 11, Issue 3, 2000, Pages 153-158

  Awad, Atif B ^a   Begdache, Lina A ^a   Fink, Carol S ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Sitosterol; Differentiation; Fatty acids; Obesity; Phytosterols; Triglyceride

Indexed keywords

CAMPESTEROL; CHOLESTEROL; DOCOSAHEXAENOIC ACID; ELAIDIC ACID; FATTY ACID; MONOUNSATURATED FATTY ACID; OLEIC ACID; PHYTOSTEROL; SITOSTEROL; STEROL; TRIACYLGLYCEROL;

ANIMAL CELL; ARTICLE; ASIAN; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET; DIETARY INTAKE; FAT INTAKE; MODEL; NONHUMAN; OBESITY; VEGETARIAN DIET;

EID: 0034019089     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-2863(99)00087-X     Document Type: Article

References (29)

1. Colditz G.A. Economic costs of obesity. Am. J. Clin. Nutr. 55:1992;503S-507S.
2. Barnard N.D., Nicholson A., Howard J.L. The medical costs attributable to meat consumption. Prev. Med. 24:1995;646-655.
3. Curhan G.C., Willett W.C., Rimm E.B., Spiegelman D., Ascherio A.L., Stampfer M.J. Birth weight and adult hypertension, diabetes mellitus, and obesity in U.S. men. Circulation. 94:1996;3246-3250.
4. Lee, R.D. and Nieman, D.C. (1996). Nutritional Assessment, 2nd ed. Mosby-Year Book, Inc., St. Louis, MO USA.
5. Awad A.B., Bernardis L.L., Fink C.S. Failure to demonstrate an effect of dietary fatty acid composition on body weight, body composition and parameters of lipid metabolism in mature rats. J. Nutr. 120:1990;1277-1282.
6. Shimomura Y., Tamura T., Suzuki M. Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet. J. Nutr. 120:1990;1291-1296.
7. Messina M., Barnes S. The role of soy products in reducing the risk of cancer. J. Natl. Cancer Inst. 83:1991;541-546.
8. Awad A.B., Chen Y.C., Fink C.S., Hennessey T. β-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Anticancer Res. 16:1996;2797-2804.
9. von Holtz R.L., Fink C.S., Awad A.B. β-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutr. Cancer. 32:1998;8-12.
10. Downie A., Fink C.S., Awad A.B. Effect of phytosterols on MDA-MB-231 breast cancer cell growth. FASEB J. 13:1999;A433.3.
11. Awad A.B., Tagle-Hernandez A.T., Fink C.S., Mendel S.L. Effect of dietary phytosterols on cell proliferation and protein kinase C activity in rat colonic mucosa. Nutr. Cancer. 27:1997;210-215.
12. Janezic S.A., Rao A.V. Dose-dependent effect of dietary phytosterols on epithelial cell proliferation of the murine colon. Food Chem. Toxicol. 30:1992;611-616.
13. Green H., Kehinde O. Spontaneous heritable changes leading to adipose conversion in 3T3 cells. Cells. 7:1976;105-113.
14. Murphy S., Albright E., Marthur S.N., Field F.J. Modifications of Caco-2 cell membrane fatty acid composition by eicosapentaenoic acid and palmitic acid Effect of cholesterol metabolism . J. Lipid Res. 29:1988;773-780.
15. Greenburg-Ofrath N., Terespolosky Y., Kahane I., Bar R. Cyclodextrins as carriers of cholesterol and fatty acids in cultivation of mycoplasms. Appl. Envir. Micro. 59:1993;547-551.
16. Ramirez-Zacarias J.L., Castro-Munozledo F., Kuri-Harcuch W. Quantification of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil Red O. Histochemistry. 97:1992;493-497.
17. Green H., Kehinde O. Sublines of mouse 3T3 cells that accumulate lipids. Cell. 1:1974;113-116.
18. Key T., Davey G. Prevalence of obesity is low in people who do not eat meat. Br. Med. J. 313:1996;816-817.
19. Montgomery, R., Conway, T.W., and Spector, A.A. (1990). Biochemistry, A Case Oriented Approach. Mosby Corp., St. Louis, MO USA.
20. Coleman P.S., Chen L.C., Sepp-Lorenzino L. Cholesterol metabolism and tumor cell proliferation. Sub-Cellular Biochem. 28:1997;363-435.
21. Grammatikos S.I., Subbaiah P.V., Vistor T.A., Miller W.M. n-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines. Br. J. Cancer. 70:1994;219-227.
22. Carlotti M., Hainault I., Guichard C., Hadjuch E., Lavau M. Fish oil in a high lard diet prevents obesity, hyperlipemia and adipocyte insulin resistance in rats. Ann. NY Acad. Sci. 683:1993;98-101.
23. Salen G., Ahrens E.N. Jr, Grundy S.M. Metabolism of β-sitosterol in man. J. Clin. Invest. 49:1970;952-967.
24. Begin M.E., Ells G., Horrobin D.F. Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidation. J. Natl. Cancer Inst. 80:1988;188-194.
25. Thompson M.P. Meal-feeding specifically induces obese mRNA expression. Biochem. Biophys. Res. Commun. 224:1996;332-337.
26. Child P., Kuksis A. Critical role of ring structure in the differential uptake of cholesterol and plant sterols by membrane preparations in vitro. J. Lipid Res. 24:1983;1196-1209.
27. Hennessey T.M. Effects of membrane plant sterols on excitable cell functions. Comp. Biochem. Physiol. 101C:1992;1-8.
28. Awad, A.B., von Holtz, R.L., Cone, J.P., Fink, C.S., and Chen, Y.-C. (1998). β-Sitosterol inhibits the growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle. Anticancer Res. 18, 487-479.
29. McDougald O.A., Hwang C.S., Fan H., Lane M.D. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc. Natl. Acad. Sci. USA. 92:1995;9034-9037.