메뉴 건너뛰기




Volumn 55, Issue 3, 2006, Pages 292-299

Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat

Author keywords

[No Author keywords available]

Indexed keywords

27 HYDROXYLASE; CAMPESTEROL; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIVER ENZYME; OXYGENASE; SITOSTEROL; STEROID 7ALPHA HYDROXYLASE; STEROL; STIGMASTEROL; UNCLASSIFIED DRUG;

EID: 32544440149     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2005.08.024     Document Type: Article
Times cited : (147)

References (36)
  • 2
    • 0017030722 scopus 로고
    • Phytosterols in aortic tissue in adults and infants
    • M.J. Mellies, T.T. Ishikawa, and C.J. Glueck Phytosterols in aortic tissue in adults and infants J Lab Clin Med 88 1976 914 921
    • (1976) J Lab Clin Med , vol.88 , pp. 914-921
    • Mellies, M.J.1    Ishikawa, T.T.2    Glueck, C.J.3
  • 3
    • 0023926545 scopus 로고
    • Plasma and biliary cholestanol related to steroid metabolism in familial hypercholesterolemia patients with and without ileal exclusion
    • P.V. Koivisto, and T.A. Miettenen Plasma and biliary cholestanol related to steroid metabolism in familial hypercholesterolemia patients with and without ileal exclusion Clin Chim Acta 174 1988 197 205
    • (1988) Clin Chim Acta , vol.174 , pp. 197-205
    • Koivisto, P.V.1    Miettenen, T.A.2
  • 4
    • 0019979503 scopus 로고
    • Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins
    • T.A. Miettenen Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins J Lipid Res 23 1982 466 473
    • (1982) J Lipid Res , vol.23 , pp. 466-473
    • Miettenen, T.A.1
  • 5
    • 0027459249 scopus 로고
    • Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol
    • M. Becker, D. Staab, and K. von Bergmann Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol J Pediatr 122 1993 292 296
    • (1993) J Pediatr , vol.122 , pp. 292-296
    • Becker, M.1    Staab, D.2    Von Bergmann, K.3
  • 6
    • 0022486322 scopus 로고
    • Usefulness of gas chromatographic profiles of plasma total lipids in diagnosis of phytosterolemia
    • A. Kuksis, J.J. Myher, and L. Marai Usefulness of gas chromatographic profiles of plasma total lipids in diagnosis of phytosterolemia J Chromatogr 381 1986 1 12
    • (1986) J Chromatogr , vol.381 , pp. 1-12
    • Kuksis, A.1    Myher, J.J.2    Marai, L.3
  • 7
    • 0025156823 scopus 로고
    • Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population
    • T.A. Miettenen, R.S. Tilvis, and Y.A. Kesaniemi Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population Am J Epidemiol 131 1990 20 31
    • (1990) Am J Epidemiol , vol.131 , pp. 20-31
    • Miettenen, T.A.1    Tilvis, R.S.2    Kesaniemi, Y.A.3
  • 8
    • 0035158733 scopus 로고    scopus 로고
    • Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
    • M.-H. Lee, K. Lu, and S. Hazard Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption Nat Genet 27 2001 79 83
    • (2001) Nat Genet , vol.27 , pp. 79-83
    • Lee, M.-H.1    Lu, K.2    Hazard, S.3
  • 9
    • 17744390348 scopus 로고    scopus 로고
    • Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    • K.E. Berge, H. Tian, and G.A. Graf Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Science 290 2000 1771 1775
    • (2000) Science , vol.290 , pp. 1771-1775
    • Berge, K.E.1    Tian, H.2    Graf, G.A.3
  • 10
    • 0034915332 scopus 로고    scopus 로고
    • Two genes that match to the STSL locus cause sitosterolemia: Genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2 encoded by ABCG5 and ABCG8, respectively
    • K. Lu, M.-H. Lee, and S. Hazard Two genes that match to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2 encoded by ABCG5 and ABCG8, respectively Am J Hum Genet 69 2001 278 290
    • (2001) Am J Hum Genet , vol.69 , pp. 278-290
    • Lu, K.1    Lee, M.-H.2    Hazard, S.3
  • 11
    • 0026766590 scopus 로고
    • Increased sitosterol absorption is offset by rapid elimination to prevent accumulation in heterozygotes with sitosterolemia
    • G. Salen, G.S. Tint, and S. Shefer Increased sitosterol absorption is offset by rapid elimination to prevent accumulation in heterozygotes with sitosterolemia Arterioscler Thromb 12 1992 563 568
    • (1992) Arterioscler Thromb , vol.12 , pp. 563-568
    • Salen, G.1    Tint, G.S.2    Shefer, S.3
  • 12
    • 0018091917 scopus 로고
    • 7-Hydroxylation of 3-oxygenated C27-, C28-, and C29-steroids in rat liver 18,000 g supernate
    • L. Aringer 7-Hydroxylation of 3-oxygenated C27-, C28-, and C29-steroids in rat liver 18,000 g supernate J Lipid Res 19 1978 933 944
    • (1978) J Lipid Res , vol.19 , pp. 933-944
    • Aringer, L.1
  • 13
    • 0020626032 scopus 로고
    • Comparison of cholesterol and β-sitosterol: Effects on jejunal fluid secretion induced by oleate, and absorption from mixed micellar solutions
    • T. Slota, N.A. Kozlov, and H.V. Ammon Comparison of cholesterol and β-sitosterol: effects on jejunal fluid secretion induced by oleate, and absorption from mixed micellar solutions Gut 24 1983 653 658
    • (1983) Gut , vol.24 , pp. 653-658
    • Slota, T.1    Kozlov, N.A.2    Ammon, H.V.3
  • 14
    • 0037944253 scopus 로고    scopus 로고
    • Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice
    • M. Igel, U. Giesa, and D. Lütjohann Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice J Lipid Res 44 2003 533 538
    • (2003) J Lipid Res , vol.44 , pp. 533-538
    • Igel, M.1    Giesa, U.2    Lütjohann, D.3
  • 15
    • 9644301170 scopus 로고    scopus 로고
    • Effect of high plant sterol-enriched diet and cholesterol absorption inhibitor, ezetimibe, on plant sterol absorption and plasma concentrations in hypercholesterolemic wild-type Kyoto (WKY) rats
    • A.K. Batta, G. Xu, and L.S. Bollineni Effect of high plant sterol-enriched diet and cholesterol absorption inhibitor, ezetimibe, on plant sterol absorption and plasma concentrations in hypercholesterolemic wild-type Kyoto (WKY) rats Metabolism 54 2005 38 48
    • (2005) Metabolism , vol.54 , pp. 38-48
    • Batta, A.K.1    Xu, G.2    Bollineni, L.S.3
  • 16
    • 9644282635 scopus 로고
    • Uber die spezifitat der resorption von sterin, abhanging von ihren konstitution
    • R. Schonheimer, H. Behring, and R.H. Hummel Uber die spezifitat der resorption von sterin, abhanging von ihren konstitution Hoppe-Seyler Z Physiol Chem 192 1930 117 124
    • (1930) Hoppe-Seyler Z Physiol Chem , vol.192 , pp. 117-124
    • Schonheimer, R.1    Behring, H.2    Hummel, R.H.3
  • 17
    • 0020582669 scopus 로고
    • Comparative lymphatic absorption of sitosterol, stigmasterol, and fucosterol and differential inhibition of cholesterol absorption
    • G.V. Vahouny, W.E. Connor, and S. Subramaniam Comparative lymphatic absorption of sitosterol, stigmasterol, and fucosterol and differential inhibition of cholesterol absorption Am J Clin Nutr 37 1983 805 809
    • (1983) Am J Clin Nutr , vol.37 , pp. 805-809
    • Vahouny, G.V.1    Connor, W.E.2    Subramaniam, S.3
  • 18
    • 0017688818 scopus 로고
    • Plant sterols as cholesterol-lowering agents: Clinical trial in patients with hypercholesterolemia and studies of sterol balance
    • A.M. Lees, H.Y.I. Mok, and M.A. McCluskey Plant sterols as cholesterol-lowering agents: clinical trial in patients with hypercholesterolemia and studies of sterol balance Atherosclerosis 28 1977 325 338
    • (1977) Atherosclerosis , vol.28 , pp. 325-338
    • Lees, A.M.1    Mok, H.Y.I.2    McCluskey, M.A.3
  • 19
    • 0014519155 scopus 로고
    • The interaction of cholesterol absorption and cholesterol synthesis in man
    • S.M. Grundy, E.H. Arhens, and J. Davignon The interaction of cholesterol absorption and cholesterol synthesis in man J Lipid Res 10 1969 304 315
    • (1969) J Lipid Res , vol.10 , pp. 304-315
    • Grundy, S.M.1    Arhens, E.H.2    Davignon, J.3
  • 20
    • 0027729980 scopus 로고
    • Comparison of intestinal absorption of cholesterol with different plant sterols in man
    • T. Heinemann, G. Aztmann, and K. von Bergmann Comparison of intestinal absorption of cholesterol with different plant sterols in man Eur J Clin Invest 23 1993 827 831
    • (1993) Eur J Clin Invest , vol.23 , pp. 827-831
    • Heinemann, T.1    Aztmann, G.2    Von Bergmann, K.3
  • 21
    • 0142074236 scopus 로고    scopus 로고
    • A missense mutation in the rat Abcg5 gene causes phytosterolemia in stroke-prone spontaneously hypertensive (SHRSP), spontaneously hypertensive (SHR), and normotensive (WKY inbred) rats
    • K.A. Scoggan, H. Gruber, and K. Lariviere A missense mutation in the rat Abcg5 gene causes phytosterolemia in stroke-prone spontaneously hypertensive (SHRSP), spontaneously hypertensive (SHR), and normotensive (WKY inbred) rats J Lipid Res 44 2003 911 916
    • (2003) J Lipid Res , vol.44 , pp. 911-916
    • Scoggan, K.A.1    Gruber, H.2    Lariviere, K.3
  • 22
    • 0642281260 scopus 로고    scopus 로고
    • The rat STSL locus: Characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats
    • H. Yu, B. Pandit, and E. Klett The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats BMC Cardiovasc Disord 3 2003 4
    • (2003) BMC Cardiovasc Disord , vol.3 , pp. 4
    • Yu, H.1    Pandit, B.2    Klett, E.3
  • 23
    • 0024451905 scopus 로고
    • Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis
    • G. Salen, V. Shore, and G.S. Tint Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis J Lipid Res 30 1989 1319 1330
    • (1989) J Lipid Res , vol.30 , pp. 1319-1330
    • Salen, G.1    Shore, V.2    Tint, G.S.3
  • 24
    • 0037025852 scopus 로고    scopus 로고
    • Simultaneous quantitation of fatty acids, sterols and bile acids in human stool by capillary gas-liquid chromatography
    • A.K. Batta, G. Salen, and P. Batta Simultaneous quantitation of fatty acids, sterols and bile acids in human stool by capillary gas-liquid chromatography J Chromatogr B 775 2002 153 161
    • (2002) J Chromatogr B , vol.775 , pp. 153-161
    • Batta, A.K.1    Salen, G.2    Batta, P.3
  • 26
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 27
    • 0025132445 scopus 로고
    • A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis
    • L.B. Nguyen, S. Shefer, and G. Salen A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis J Clin Invest 86 1990 923 931
    • (1990) J Clin Invest , vol.86 , pp. 923-931
    • Nguyen, L.B.1    Shefer, S.2    Salen, G.3
  • 28
    • 0032814083 scopus 로고    scopus 로고
    • Bile acid synthesis in the Smith-Lemli-Opitz syndrome: Effects of dehydrocholesterols on cholesterol 7α-hydroxylase and 27-hydroxylase activities in rat liver
    • A. Honda, G. Salen, and S. Shefer Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7α-hydroxylase and 27-hydroxylase activities in rat liver J Lipid Res 40 1999 1520 1528
    • (1999) J Lipid Res , vol.40 , pp. 1520-1528
    • Honda, A.1    Salen, G.2    Shefer, S.3
  • 29
    • 0016275140 scopus 로고
    • Validation of a dual-isotope plasma ratio method for measurement of cholesterol absorption in rats
    • D.B. Zilversmit, and L.B. Hughes Validation of a dual-isotope plasma ratio method for measurement of cholesterol absorption in rats J Lipid Res 15 1974 465 473
    • (1974) J Lipid Res , vol.15 , pp. 465-473
    • Zilversmit, D.B.1    Hughes, L.B.2
  • 30
    • 0035652338 scopus 로고    scopus 로고
    • Mechanism of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats
    • I. Ikeda, H. Nakagiri, and M. Sugano Mechanism of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats Metabolism 50 2001 1361 1368
    • (2001) Metabolism , vol.50 , pp. 1361-1368
    • Ikeda, I.1    Nakagiri, H.2    Sugano, M.3
  • 31
    • 0019796389 scopus 로고
    • Thin-layer and gas-liquid chromatographic identification of neutral steroids in human and rat feces
    • D.J. McNamara, A. Proia, and T.A. Miettinen Thin-layer and gas-liquid chromatographic identification of neutral steroids in human and rat feces J Lipid Res 22 1981 474 484
    • (1981) J Lipid Res , vol.22 , pp. 474-484
    • McNamara, D.J.1    Proia, A.2    Miettinen, T.A.3
  • 33
    • 9644281617 scopus 로고    scopus 로고
    • Disruption of cholesterol homeostasis by plant sterols
    • C. Yang, L. Yu, and W. Li Disruption of cholesterol homeostasis by plant sterols J Clin Invest 114 2004 813 822
    • (2004) J Clin Invest , vol.114 , pp. 813-822
    • Yang, C.1    Yu, L.2    Li, W.3
  • 34
    • 0037466407 scopus 로고    scopus 로고
    • Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7a-hydroxylase gene
    • E. Owsley, and J.Y.L. Chiang Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7a-hydroxylase gene Biochem Biophys Res Commun 304 2003 191 195
    • (2003) Biochem Biophys Res Commun , vol.304 , pp. 191-195
    • Owsley, E.1    Chiang, J.Y.L.2
  • 35
    • 0017643738 scopus 로고
    • Effect of plant sterol esters on the absorption of dietary cholesterol
    • F.H. Mattson, R.A. Volpenhein, and B.A. Erickson Effect of plant sterol esters on the absorption of dietary cholesterol J Nutr 107 1977 1139 1146
    • (1977) J Nutr , vol.107 , pp. 1139-1146
    • Mattson, F.H.1    Volpenhein, R.A.2    Erickson, B.A.3
  • 36
    • 0042206849 scopus 로고    scopus 로고
    • Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels
    • for the Stresa Workshop participants M.B.
    • M.B. Katan for the Stresa Workshop participants Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels Mayo Clin Proc 78 2003 965 978
    • (2003) Mayo Clin Proc , vol.78 , pp. 965-978
    • Katan1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.