Research Spotlight: Magnetofection™ platform: From magnetic nanoparticles to novel nucleic acid therapeutics

Therapeutic Delivery

Volumn 2, Issue 6, 2011, Pages 717-726

  Plank, Christian ^a   Vlaskou, Dialechti ^a   Schillinger, Ulrike ^a   Mykhaylyk, Olga ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; COPOLYMER; CYTOKINE; MAGNETIC NANOPARTICLE; NANOPARTICLE; NUCLEIC ACID; ONCOLYTIC VIRUS; PARVOVIRUS VECTOR; RETROVIRUS VECTOR; SMALL INTERFERING RNA; METAL NANOPARTICLE;

ARTICLE; CANCER IMMUNOTHERAPY; CELL LABELING; DENTISTRY; DNA MODIFICATION; DRUG FORMULATION; DRUG RESEARCH; DRUG TARGETING; FIBROSARCOMA; GENE EXPRESSION REGULATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MICROBUBBLE; NANOBIOTECHNOLOGY; NANOTECHNOLOGY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; ORTHOPEDIC SURGERY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TISSUE ENGINEERING; ULTRASOUND; VETERINARY MEDICINE; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTIVITY; ADENOVIRUS; ANIMAL DISEASE; CHEMISTRY; GENE THERAPY; GENE TRANSFER; GENE VECTOR; MAGNETIC FIELD; METABOLISM; METHODOLOGY;

ADENOVIRIDAE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MAGNETIC FIELDS; METAL NANOPARTICLES; TISSUE ENGINEERING;

EID: 79960286701     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.37     Document Type: Article

References (32)

1. Mah C, Zolotukhin I, Fraites TJ, Dobson J, Batich C, Byrne BJ. Microsphere-mediated delivery of recombinant AAV vectors in vitro and in vivo. Mol. Ther. 1(5), S239 (2000)
2. Plank C, Scherer F, Schillinger U, Anton M. Magnetofection: enhancement and localization of gene delivery with magnetic particles under the influence of a magnetic field. J. Gene Med. 2(5), 24 (2000)
3. Hughes C, Galea-Lauri J, Farzaneh F, Darling D. Streptavidin paramagnetic particles provide a choice of three affinity-based capture and magnetic concentration strategies for retroviral vectors. Mol. Ther. 3(4), 623-630 (2001) (Pubitemid 32509857)
4. Scherer F, Anton M, Schillinger U et al. Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther. 9(2), 102-109 (2002) (Pubitemid 34189525)
5. Mah C, Fraites TJ Jr, Zolotukhin I et al. Improved method of recombinant AAV2 delivery for systemic targeted gene therapy. Mol. Ther. 6(1), 106-112 (2002) (Pubitemid 36124277)
6. Mykhaylyk O, Antequera YS, Vlaskou D, Plank C. Generation of magnetic nonviral gene transfer agents and Magnetofection in vitro. Nat. Protoc. 2(10), 2391-2411 (2007)
7. Mykhaylyk O, Vlaskou D, Tresilwised N, Pithayanukul P, Moller W, Plank C. Magnetic nanoparticle formulations for DNA and siRNA delivery. J. Magn. Magn. Mat. 311, 275-281 (2007) (Pubitemid 46401036)
8. Mykhaylyk O, Zelphati O, Hammerschmid E, Anton M, Rosenecker J, Plank C. Recent advances in Magnetofection and its potential to deliver siRNAs in vitro. Methods Mol. Biol. 487, 111-146 (2009)
9. Mykhaylyk O, Sanchez-Antequera Y, Vlaskou D et al. Liposomal Magnetofection. Methods Mol. Biol. 605, 487-525 (2010)
10. Mykhaylyk O, Zelphati O, Rosenecker J, Plank C. siRNA delivery by Magnetofection. Curr. Opin. Mol. Ther. 10(5), 493-505 (2008)
11. Sanchez-Antequera Y, Mykhaylyk O, Thalhammer S, Plank C. Gene delivery to Jurkat T cells using nonviral vectors associated with magnetic nanoparticles. Int. J. Biomed. Nanosci. Nanotechnol. 1(2-4), 202-229 (2010)
12. Tresilwised N, Pithayanukul P, Mykhaylyk O et al. Boosting oncolytic adenovirus potency with magnetic nanoparticles and magnetic force. Mol. Pharm. 7(4), 1069-1089 (2010)
13. Huth S, Lausier J, Gersting Sw et al. Insights into the mechanism of Magnetofection using PEI-based magnetofectins for gene transfer. J. Gene Med. 6(8), 923-936 (2004) (Pubitemid 40228108)
14. Namgung R, Singha K, Yu Mk et al. Hybrid superparamagnetic iron oxide nanoparticle-branched polyethylenimine magnetoplexes for gene transfection of vascular endothelial cells. Biomaterials 31(14), 4204-4213 (2010)
15. Sauer AM, De Bruin KG, Ruthardt N, Mykhaylyk O, Plank C, Brauchle C. Dynamics of magnetic lipoplexes studied by single particle tracking in living cells. J. Control. Release 137(2), 136-145 (2009)
16. Mykhaylyk O, Steingotter A, Perea H, Aigner J, Botnar R, Plank C. Nucleic acid delivery to magnetically-labeled cells in a 2D array and at the luminal surface of cell culture tube and their detection by MRI. J. Biomed. Nanotechnol. 5(6), 692-706 (2009)
17. Unger EC, Mccreery TP, Sweitzer RH, Caldwell VE, Wu YQ. Acoustically active lipospheres containing paclitaxel - a new therapeutic ultrasound contrast agent. Invest. Radiol. 33(12), 886-892 (1998) (Pubitemid 30247061)
18. Vlaskou D, Mykhaylyk O, Krötz F et al. Magnetic and acoustically active lipospheres for magnetically targeted nucleic acid delivery. Adv. Funct. Mater. 20(22), 3881-3894 (2010)
19. Stride E, Porter C, Prieto AG, Pankhurst Q. Enhancement of microbubble mediated gene delivery by simultaneous exposure to ultrasonic and magnetic fields. Ultrasound Med. Biol. 35(5), 861-868 (2009)
20. Vlaskou D, Pradhan P, Bergemann C et al. Magnetic microbubbles: magnetically targeted and ultrasound-triggered vectors for gene delivery in vitro. AIP Conf. Proc. 1311(1), 485-494 (2010)
21. Del Pino P, Munoz-Javier A, Vlaskou D, Rivera Gil P, Plank C, Parak WJ. Gene silencing mediated by magnetic lipospheres tagged with small interfering RNA. Nano Lett. 10(10), 3914-3921 (2010)
22. Holzbach T, Vlaskou D, Neshkova I et al. Non-viral VEGF(165) gene therapy - Magnetofection of acoustically active magnetic lipospheres (magnetobubbles) increases tissue survival in an oversized skin flap model. J. Cell Mol. Med. 14(3), 587-599 (2010)
23. Pradhan P, Giri J, Rieken F et al. Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy. J. Control. Release 142(1), 108-121 (2010)
24. Sanchez-Antequera Y, Mykhaylyk O, van Til NP et al. Magselectofection: an integrated method of nanomagnetic separation and genetic modification of target cells. Blood 117(16), e171-e181 (2011)
25. Huttinger C, Hirschberger J, Jahnke A et al. Neoadjuvant gene delivery of feline granulocyte-macrophage colony-stimulating factor using Magnetofection for the treatment of feline fibrosarcomas: a Phase I trial. J. Gene Med. 10(6), 655-667 (2008) (Pubitemid 351936538)
26. Schillinger U, Brill T, Rudolph C et al. Advances in Magnetofection - magnetically guided nucleic acid delivery. J. Magn. Magn. Mat. 293(1), 501-508 (2005) (Pubitemid 40608971)
27. Jahnke A, Hirschberger J, Fischer C et al. Intra-tumoral gene delivery of feIL-2, feIFN-g and feGM-CSF using Magnetofection as a neoadjuvant treatment option for feline fibrosarcomas: a Phase-I study. J. Vet. Med. Series A 54(10), 599-606 (2007) (Pubitemid 350206008)
28. Scherer F, Schillinger U, Putz U, Stemberger A, Plank C. Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo. J. Gene Med. 4(6), 634-643 (2002) (Pubitemid 40277187)
29. Schillinger U, Wexel G, Hacker C et al. A fibrin glue composition as carrier for nucleic acid vectors. Pharm. Res. 25(12), 2946-2962 (2008)
30. Reckhenrich AK, Hopfner U, Krotz F et al. Bioactivation of dermal scaffolds with a non-viral copolymer-protected gene vector. Biomaterials 32(7), 1996-2003 (2011)
31. Plank Lab http://plank-lab.net/
32. Cluster of Excellence Nanosystems Initiative Munich www.nano-initiative- munich.de