An arginine residue instead of a conserved leucine residue in the recognition helix of the finger 3 of Zif268 stabilizes the domain structure and mediates DNA binding

Biochemistry

Volumn 50, Issue 28, 2011, Pages 6266-6272

  Negi, Shigeru ^a   Imanishi, Miki ^b   Sasaki, Maeko ^a   Tatsutani, Kazuya ^b   Futaki, Shiroh ^b   Sugiura, Yukio ^a  

^a DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC CARBON; ARG RESIDUES; ARGININE RESIDUE; DNA BINDING; DNA RECOGNITION; DOMAIN STRUCTURE; GUANIDINIUM; HYDROPHOBIC CORE; LEUCINE RESIDUES; METAL BINDING PROPERTIES; PEPTIDE CONFORMATION; PHOSPHATE BACKBONE; SECONDARY STRUCTURES; SIDE CHAIN STRUCTURE; SIDE-CHAINS; WILD TYPES; ZINC FINGER; ZINC FINGER DOMAINS; ZINC FINGER PROTEIN;

AMINO ACIDS; BINDING ENERGY; CRYSTALS; HYDROGEN BONDS; PEPTIDES; ZINC;

DNA;

ARGININE; CARBON; DNA; GLUTAMINE; GUANIDINE; HOMOGLUTAMINE; LEUCINE; LYSINE; PEPTIDE; PHOSPHATE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER TRANSCRIPTION FACTOR 268;

ARTICLE; DNA BINDING; HYDROGEN BOND; METAL BINDING; MUTANT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; THERMOSTABILITY; WILD TYPE; ZINC FINGER MOTIF;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; HUMANS; LEUCINE; MICE; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS; ZINC FINGERS;

EID: 79960274555     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200697p     Document Type: Article

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