Economy in protein design: Evolution of a metal-independent ββα motif based on the zinc finger domains

Journal of the American Chemical Society

Volumn 118, Issue 13, 1996, Pages 3073-3081

  Struthers, Mary D ^a   Cheng, Richard P ^a   Imperiali, Barbara ^a  

^a California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DESIGN; MOLECULAR STRUCTURE; POLYPEPTIDES; SIMULATED ANNEALING; STRUCTURE (COMPOSITION); SYNTHESIS (CHEMICAL); THREE DIMENSIONAL; ZINC COMPOUNDS;

CIRCULAR DICHROISM; HAIRPIN FORMATION; METAL BINDING EFFECTS; METAL-INDEPENDENT MOTIFS; ZINC FINGER DOMAINS;

PROTEINS;

ARTICLE; CIRCULAR DICHROISM; DRUG DESIGN; NUCLEAR MAGNETIC RESONANCE; PROTEIN DOMAIN; PROTEIN STRUCTURE;

EID: 0030567375     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja954014u     Document Type: Article

References (5)

1. Regan, L.; DeGrado, W. F. Science 1988, 241, 976-978.
2. Osterhout, J. J.; Handel, T.; Na, G.; Toumadje, A.; Long, R. C.; Connolly, P. J.; Hoch, J. C.; Johnson, W. C., Jr.; Live, D.; DeGrado, W. F. J. Am. Chem. Soc. 1992, 114, 331-337.
3. Hecht, M. H. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 8729-8730.
4. Betz, S. F.; Raleigh, D. P.; DeGrado, W. F. Curr. Opin. Struct. Biol. 1993, 3, 601-610.
5. Fezoui, Y.; Weaver, D. L.; Osterhout, J. J. J. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 3675-3679.