-
1
-
-
68749091924
-
Pyrazolopyrimidines: Old Molecules, New Targets
-
Recent review papers
-
Recent review papers: Schenone, S.; Radi, M.; Botta, M. Pyrazolopyrimidines: Old Molecules, New Targets Targets in Heterocyclic Systems 2007, 11, 44-69
-
(2007)
Targets in Heterocyclic Systems
, vol.11
, pp. 44-69
-
-
Schenone, S.1
Radi, M.2
Botta, M.3
-
2
-
-
33947596537
-
Recent Syntheses of Pyrazolo[3,4- d ]pyrimidine Ring Systems
-
Dang, Q. Recent Syntheses of Pyrazolo[3,4- d ]pyrimidine Ring Systems Recent Research Developments in Organic Chemistry 2002, 6, 431-447
-
(2002)
Recent Research Developments in Organic Chemistry
, vol.6
, pp. 431-447
-
-
Dang, Q.1
-
3
-
-
52449116295
-
Facile One-Pot Synthesis and Antimycobacterial Evaluation of Pyrazolo[3,4- d ]pyrimidines
-
Trivedi, A.; Dodiya, D.; Surani, J.; Jarsania, S.; Mathukiya, H.; Ravat, N.; Shah, V. Facile One-Pot Synthesis and Antimycobacterial Evaluation of Pyrazolo[3,4- d ]pyrimidines Arch. Pharm. Chem. Life Sci. 2008, 341, 435-439
-
(2008)
Arch. Pharm. Chem. Life Sci.
, vol.341
, pp. 435-439
-
-
Trivedi, A.1
Dodiya, D.2
Surani, J.3
Jarsania, S.4
Mathukiya, H.5
Ravat, N.6
Shah, V.7
-
4
-
-
9844235351
-
Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines
-
DOI 10.1021/jm970124v
-
Traxler, P.; Bold, G.; Frei, J.; Lang, M.; Lydon, N.; Mett, H.; Buchdunger, E.; Meyer, T.; Mueller, M.; Furet, P. Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4- d ]pyrimidines J. Med. Chem. 1997, 40, 3601-3616 (Pubitemid 27465092)
-
(1997)
Journal of Medicinal Chemistry
, vol.40
, Issue.22
, pp. 3601-3616
-
-
Traxler, P.1
Bold, G.2
Frei, J.3
Lang, M.4
Lydon, N.5
Mett, H.6
Buchdunger, E.7
Meyer, T.8
Mueller, M.9
Furet, P.10
-
6
-
-
72249113146
-
Novel Purine and Pyrazolo[3,4- d ]pyrimidine Inhibitors of PI3 Kinase-[α]: Hit to Lead Studies
-
Gilbert, A. M.; Nowak, P.; Brooijmans, N.; Bursavich, M. G.; Dehnhardt, C.; Santos, E. D.; Feldberg, L. R.; Hollander, I.; Kim, S.; Lombardi, S.; Park, K.; Venkatesa, A. M.; Mallon, R. Novel Purine and Pyrazolo[3,4- d ]pyrimidine Inhibitors of PI3 Kinase-[α]: Hit to Lead Studies Bioorg. Med. Chem. Lett. 2010, 20, 636-639
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 636-639
-
-
Gilbert, A.M.1
Nowak, P.2
Brooijmans, N.3
Bursavich, M.G.4
Dehnhardt, C.5
Santos, E.D.6
Feldberg, L.R.7
Hollander, I.8
Kim, S.9
Lombardi, S.10
Park, K.11
Venkatesa, A.M.12
Mallon, R.13
-
7
-
-
72249090391
-
Discovery of 3,6-Dihydro-2 H -pyran as a Morpholine Replacement in 6-Aryl-1 H -pyrazolo[3,4- d ]pyrimidines and 2-Arylthieno[3,2- d ]pyrimidines: ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR)
-
Kaplan, J.; Verheijen, J. C.; Brooijmans, N.; Toral-Barza, L.; Hollander, I.; Yu, K.; Zask, A. Discovery of 3,6-Dihydro-2 H -pyran as a Morpholine Replacement in 6-Aryl-1 H -pyrazolo[3,4- d ]pyrimidines and 2-Arylthieno[3,2- d ]pyrimidines: ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR) Bioorg. Med. Chem. Lett. 2010, 20, 640-643
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 640-643
-
-
Kaplan, J.1
Verheijen, J.C.2
Brooijmans, N.3
Toral-Barza, L.4
Hollander, I.5
Yu, K.6
Zask, A.7
-
8
-
-
0038060520
-
Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors
-
DOI 10.1016/S0223-5234(03)00065-5
-
Kim, D. C.; Lee, Y. R.; Yang, B.-S.; Shin, K. J.; Kim, D. J.; Chung, B. Y.; Yoo, K. H. Synthesis and Biological Evaluations of Pyrazolo[3,4- d ]pyrimidines as Cyclin-Dependent Kinase 2 Inhibitors Eur. J. Med. Chem. 2003, 38, 525-532 (Pubitemid 36588919)
-
(2003)
European Journal of Medicinal Chemistry
, vol.38
, Issue.5
, pp. 525-532
-
-
Kim, D.C.1
Lee, Y.R.2
Yang, B.-S.3
Shin, K.J.4
Kim, D.J.5
Chung, B.Y.6
Yoo, K.H.7
-
9
-
-
11144355929
-
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation
-
DOI 10.1016/j.bmcl.2004.03.013, PII S0960894X04003452
-
Schenone, S.; Bruno, O.; Ranise, A.; Bondavalli, F.; Brullo, C.; Fossa, P.; Mosti, L.; Menozzi, G.; Carraro, F; Naldini, A.; Bernini, C.; Manetti, F.; Botta, M. New Pyrazolo[3,4- d ]pyrimidines Endowed with A431 Antiproliferative Activity and Inhibitory Properties of Src Phosphorylation Bioorg. Med. Chem. Lett. 2004, 14, 2511-2517 (Pubitemid 38515694)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.10
, pp. 2511-2517
-
-
Schenone, S.1
Bruno, O.2
Ranise, A.3
Bondavalli, F.4
Brullo, C.5
Fossa, P.6
Mosti, L.7
Menozzi, G.8
Carraro, F.9
Naldini, A.10
Bernini, C.11
Manetti, F.12
Botta, M.13
-
10
-
-
77952723730
-
Calcium-Dependent Protein Kinase 1 is an Essential Regulator of Exocytosis in Toxoplasma
-
Lourido, S.; Shuman, J.; Zhang, C.; Shokat, K. M.; Hui, R.; Sibley, L. D. Calcium-Dependent Protein Kinase 1 is an Essential Regulator of Exocytosis in Toxoplasma Nature 2010, 465, 359-362
-
(2010)
Nature
, vol.465
, pp. 359-362
-
-
Lourido, S.1
Shuman, J.2
Zhang, C.3
Shokat, K.M.4
Hui, R.5
Sibley, L.D.6
-
11
-
-
78149420077
-
A Myosin v Inhibitor Based on Privileged Chemical Scaffolds
-
Islam, K.; Chin, H. F.; Olivares, A. O.; Saunders, L. P.; De La Cruz, E. M.; Kapoor, T. M. A Myosin V Inhibitor Based on Privileged Chemical Scaffolds Angew. Chem., Int. Ed. Engl. 2010, 49 (45) 8484-8488
-
(2010)
Angew. Chem., Int. Ed. Engl.
, vol.49
, Issue.45
, pp. 8484-8488
-
-
Islam, K.1
Chin, H.F.2
Olivares, A.O.3
Saunders, L.P.4
De La Cruz, E.M.5
Kapoor, T.M.6
-
13
-
-
85038361565
-
-
WO2008094602 A2
-
Kasibhatla, S. R.; Hong, K.; Zhang, L.; Boehm, M. F.; Fan, J.; Le Brazidec, J. Modulators of Mitotic Kinases. WO2008094602 A2, 2008.
-
(2008)
Modulators of Mitotic Kinases
-
-
Kasibhatla, S.R.1
Hong, K.2
Zhang, L.3
Boehm, M.F.4
Fan, J.5
Le Brazidec, J.6
-
15
-
-
27944439591
-
Pyrazoloheteroaryls: Novel p38α MAP kinase inhibiting scaffolds with oral activity
-
DOI 10.1016/j.bmcl.2005.10.015, PII S0960894X05012953
-
Revesz, L.; Blum, E.; Di Padova, F. E.; Buhl, T.; Feifel, R.; Gram, H.; Hiestand, P.; Manning, U.; Neumann, U.; Rucklin, G. Pyrazoloheteroaryls: Novel P38α MAP Kinase Inhibiting Scaffolds with Oral Activity Bioorg. Med. Chem. Lett. 2006, 16 (2) 262-266 (Pubitemid 41680609)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.2
, pp. 262-266
-
-
Revesz, L.1
Blum, E.2
Di Padova, F.E.3
Buhl, T.4
Feifel, R.5
Gram, H.6
Hiestand, P.7
Manning, U.8
Neumann, U.9
Rucklin, G.10
-
16
-
-
0030431326
-
Pharmacological modulation of myocardial tumor necrosis factor α production by phosphodiesterase inhibitors
-
Bergman, M. R.; Holycross, B. J. Pharmacological Modulation of Myocardial Tumor Necrosis Factor alpha Production by Phosphodiesterase Inhibitors J. Pharmacol. Exp. Ther. 1996, 279, 247-254 (Pubitemid 27166918)
-
(1996)
Journal of Pharmacology and Experimental Therapeutics
, vol.279
, Issue.1
, pp. 247-254
-
-
Bergman, M.R.1
Holycross, B.J.2
-
17
-
-
0037740664
-
Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III: Design, synthesis, and biological evaluation
-
DOI 10.1021/jm020483c
-
Ali, A.; Taylor, G. E.; Ellsworth, K.; Harris, G.; Painter, R.; Silver, L. L.; Young, K. Novel Pyrazolo[3,4- d ]pyrimidine-Based Inhibitors of Staphlococcus aureus DNA Polymerase III: Design, Synthesis, and Biological Evaluation J. Med. Chem. 2003, 46, 1824-1830 (Pubitemid 36532226)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.10
, pp. 1824-1830
-
-
Ali, A.1
Taylor, G.E.2
Ellsworth, K.3
Harris, G.4
Painter, R.5
Silver, L.L.6
Young, K.7
-
18
-
-
11144354668
-
A-420983: A potent, orally active inhibitor of lck with efficacy in a model of transplant rejection
-
DOI 10.1016/j.bmcl.2004.02.101, PII S0960894X04003609
-
Borhani, D. W.; Calderwood, D. J.; Friedman, M. M.; Hirst, G. C.; Li, B.; Leung, A. K. W.; McRae, B.; Ratnofsky, S.; Ritter, K.; Waegell, W. A-420983: a Potent, Orally Active Inhibitor of Lck with Efficacy in a Model of Transplant Rejection Bioorg. Med. Chem. Lett. 2004, 14, 2613-2616 (Pubitemid 38515713)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.10
, pp. 2613-2616
-
-
Borhani, D.W.1
Calderwood, D.J.2
Friedman, M.M.3
Hirst, G.C.4
Li, B.5
Leung, A.K.W.6
McRae, B.7
Ratnofsky, S.8
Ritter, K.9
Waegell, W.10
-
19
-
-
56249103764
-
Identification and Optimization of N 3, N 6-Diaryl-1 H -pyrazolo[3,4- d ]pyrimidine-3,6-diamines as a Novel Class of ACK1 Inhibitors
-
Kopecky, D. J.; Hao, X.; Chen, Y.; Fu, J.; Jiao, X.; Jaen, J. C.; Cardozo, M. G.; Liu, J.; Wang, Z.; Walker, N. P. C.; Wesche, H.; Li, S.; Farrelly, E.; Xiao, S.; Kayser, F. Identification and Optimization of N 3, N 6-Diaryl-1 H -pyrazolo[3,4- d ]pyrimidine-3,6-diamines as a Novel Class of ACK1 Inhibitors Bioorg. Med. Chem. Lett. 2008, 18 (24) 6352-6356
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, Issue.24
, pp. 6352-6356
-
-
Kopecky, D.J.1
Hao, X.2
Chen, Y.3
Fu, J.4
Jiao, X.5
Jaen, J.C.6
Cardozo, M.G.7
Liu, J.8
Wang, Z.9
Walker, N.P.C.10
Wesche, H.11
Li, S.12
Farrelly, E.13
Xiao, S.14
Kayser, F.15
-
20
-
-
77952802152
-
A Facile One-pot Synthesis of 1-Arylpyrazolo[3,4- d ]Pyrimidin-4-ones
-
Zhang, X.; Lin, Q.; Zhong, P. A Facile One-pot Synthesis of 1-Arylpyrazolo[3,4- d ]Pyrimidin-4-ones Molecules 2010, 15, 3079-3086
-
(2010)
Molecules
, vol.15
, pp. 3079-3086
-
-
Zhang, X.1
Lin, Q.2
Zhong, P.3
-
21
-
-
41949140578
-
Microwave-Assisted Synthesis of Pyrazolo[3,4- d ]pyrimidines from 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde under Solvent-Free Conditions
-
Quiroga, J.; Trilleras, J.; Insuasty, B.; Abonia, R.; Nogueras, M.; Marchal, A.; Cobo, J. Microwave-Assisted Synthesis of Pyrazolo[3,4- d ]pyrimidines from 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde under Solvent-Free Conditions Tetrahedron Lett. 2008, 49, 3257-3259
-
(2008)
Tetrahedron Lett.
, vol.49
, pp. 3257-3259
-
-
Quiroga, J.1
Trilleras, J.2
Insuasty, B.3
Abonia, R.4
Nogueras, M.5
Marchal, A.6
Cobo, J.7
-
22
-
-
41849119877
-
Concise synthesis of 2-amino-4(3H)-quinazolinones from simple (hetero)aromatic amines
-
DOI 10.1021/jo7026883
-
Zeghida, W.; Debray, J.; Chierici, S.; Dumy, P.; Demeunynck, M. Concise Synthesis of 2-Amino-4(3H)-quinazolinones from Simple (Hetero)aromatic Amines J. Org. Chem. 2008, 73, 2473-2475 (Pubitemid 351497789)
-
(2008)
Journal of Organic Chemistry
, vol.73
, Issue.6
, pp. 2473-2475
-
-
Zeghida, W.1
Debray, J.2
Chierici, S.3
Dumy, P.4
Demeunynck, M.5
-
23
-
-
0024360736
-
Studies in nucleosides: Part XXII-synthesis of 4-amino/hydroxy-1- (cyclohexyl/2'-tetrahydropyranyl)-6-amino/n-propoxy-1H- pyrazolo[3,4-d]- pyrimidines and their antiallergic activity
-
Deo, K.; Avasthi, K.; Pratap, R.; Bhakuni, D. S.; Kar, K. Studies in Nucleosides. Part XXII. Synthesis of 4-Amino/hydroxy-1-(cyclohexyl/2′- tetrahydropyranyl)-6-amino/ n -Propoxy-1 H -pyrazolo[3,4- d ]pyrimidines and Their Antiallergic Activity Ind. J. Chem., Sect. B 1989, 28B, 237-241 (Pubitemid 19199243)
-
(1989)
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry
, vol.28
, Issue.3
, pp. 237-241
-
-
Deo, K.1
Avasthi, K.2
Pratap, R.3
Bhakuni, D.S.4
Kar, K.5
-
24
-
-
0001874909
-
Regioselective Alkylation of 4,6-Bis(methylthio)-1 H -pyrazolo[3,4- d ]pyrimidine
-
Garg, N.; Avasthi, K.; Bhakuni, D. S. Regioselective Alkylation of 4,6-Bis(methylthio)-1 H -pyrazolo[3,4- d ]pyrimidine Synthesis 1989, 876-878
-
(1989)
Synthesis
, pp. 876-878
-
-
Garg, N.1
Avasthi, K.2
Bhakuni, D.S.3
-
25
-
-
0030059735
-
A short synthesis of 4-substituted 1-(hydroxyalkyl)-1H-pyrazolo[3,4-d] pyrimidines
-
DOI 10.1016/0040-4020(95)01060-2
-
Zacharie, B.; Connolly, T. P.; Rej, R.; Attardo, G.; Penney, C. L. A Short Synthesis of 4-Substituted 1-(Hydroxyalkyl)-1 H -pyrazolo[3,4- d ]pyrimidines Tetrahedron 1996, 52, 2271-2278 (Pubitemid 26046629)
-
(1996)
Tetrahedron
, vol.52
, Issue.7
, pp. 2271-2278
-
-
Zacharie, B.1
Connolly, T.P.2
Rej, R.3
Attardo, G.4
Penney, C.L.5
-
26
-
-
33947593212
-
Efficient and regioselective N-1 alkylation of 4-chloropyrazolo[3,4-d] pyrimidine
-
DOI 10.1016/j.tetlet.2007.02.116, PII S0040403907004029
-
Brandvang, M.; Gundersen, L.-L. Efficient and Regioselective N-1 Alkylation of 4-Chloropyrazolo[3,4- d ]pyrimidine Tetrahedron Lett. 2007, 48, 3057-3059 (Pubitemid 46483589)
-
(2007)
Tetrahedron Letters
, vol.48
, Issue.17
, pp. 3057-3059
-
-
Braendvang, M.1
Gundersen, L.-L.2
-
27
-
-
70349278432
-
Synthesis of 3-(1,2,3-Triazol-1-yl)- and 3-(1,2,3-Triazol-4-yl)- substituted pyrazolo[3,4- d ]pyrimidin-4-amines via Click Chemistry: Potential Inhibitors of the Plasmodium falciparum PfPK7 Protein Kinase
-
Klein, M.; Diner, P.; Dominique, D. S.; Doerig, C.; Grotli, M. Synthesis of 3-(1,2,3-Triazol-1-yl)- and 3-(1,2,3-Triazol-4-yl)-substituted pyrazolo[3,4- d ]pyrimidin-4-amines via Click Chemistry: Potential Inhibitors of the Plasmodium falciparum PfPK7 Protein Kinase Org. Biomol. Chem. 2009, 7, 3421-3429
-
(2009)
Org. Biomol. Chem.
, vol.7
, pp. 3421-3429
-
-
Klein, M.1
Diner, P.2
Dominique, D.S.3
Doerig, C.4
Grotli, M.5
-
28
-
-
33947477203
-
Pyrazolone(3,4- d)pyrimidines. I. The Preparation of 6- Methylthiopyrazolono-(3,4- d)pyrimidines1,2,3
-
Hauser, M.; Peters, E.; Tieckelmann, H. Pyrazolone(3,4- d)pyrimidines. I. The Preparation of 6-Methylthiopyrazolono-(3,4- d)pyrimidines1,2,3 J. Org. Chem. 1960, 25, 1570-1573
-
(1960)
J. Org. Chem.
, vol.25
, pp. 1570-1573
-
-
Hauser, M.1
Peters, E.2
Tieckelmann, H.3
-
29
-
-
0141843363
-
Untersuchungen in der Pyrimidinreihe, XXX: Synthese und Eigenschaften von Pyrimidin-sulfoxiden, -sulfonen und -nitraminen
-
Southon, I. W.; Pfleiderer, W. Untersuchungen in der Pyrimidinreihe, XXX: Synthese und Eigenschaften von Pyrimidin-sulfoxiden, -sulfonen und -nitraminen Chem. Ber. 1978, 111, 1006-1018
-
(1978)
Chem. Ber.
, vol.111
, pp. 1006-1018
-
-
Southon, I.W.1
Pfleiderer, W.2
-
30
-
-
79960261961
-
-
WO2007023105.
-
Arora, N.; Billedeau, R. J.; Dewdney, N. J.; Gabriel, T.; Goldstein, D. M.; O'Yang, C.; Soth, M.; Trejo-Martin, T. A. Preparation of Fused Pyrazole Derivatives as P38 MAP Kinase Inhibitors. WO2007023105, 2007.
-
(2007)
Preparation of Fused Pyrazole Derivatives As P38 MAP Kinase Inhibitors
-
-
Arora, N.1
Billedeau, R.J.2
Dewdney, N.J.3
Gabriel, T.4
Goldstein, D.M.5
O'Yang, C.6
Soth, M.7
Trejo-Martin, T.A.8
-
31
-
-
33644788326
-
Nucleosides. Part XVIII. Synthesis of 6-Methoxy/Methylthio-4-N- substituted-1-(2′-tetrahydropyranyl/2′-hydroxyethoxymethyl)-1 H -pyrazolo [3,4- d ]pyrimidines and Their Biological Activity
-
Deo, K.; Avasthi, K.; Pratap, Ram; Kar, K.; Bhakuni, D. S. Nucleosides. Part XVIII. Synthesis of 6-Methoxy/Methylthio-4-N-substituted-1-(2′- tetrahydropyranyl/2′-hydroxyethoxymethyl)-1 H -pyrazolo [3,4- d ]pyrimidines and Their Biological Activity Ind. J. Chem. Sec. B 1987, 26B, 963-967
-
(1987)
Ind. J. Chem. Sec. B
, vol.26
, pp. 963-967
-
-
Deo, K.1
Avasthi, K.2
Pratap, R.3
Kar, K.4
Bhakuni, D.S.5
-
32
-
-
0030490253
-
Ligand Coupling Reactions of 2-Pyridyl, 4-Pyridyl, and 2-Pyrimidyl Sulfoxides with Grignard Reagents
-
Oae, S.; Takeda, T.; Uenishi, J.; Wakabayashi, S. Ligand Coupling Reactions of 2-Pyridyl, 4-Pyridyl, and 2-Pyrimidyl Sulfoxides with Grignard Reagents Phosphorus, Sulfur, Silicon Relat. Elem. 1996, 115, 179-182
-
(1996)
Phosphorus, Sulfur, Silicon Relat. Elem.
, vol.115
, pp. 179-182
-
-
Oae, S.1
Takeda, T.2
Uenishi, J.3
Wakabayashi, S.4
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