Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 640-643

  Kaplan, Joshua ^a   Verheijen, Jeroen C ^a   Brooijmans, Natasja ^a   Toral Barza, Lourdes ^a   Hollander, Irwin ^a   Yu, Ker ^a   Zask, Arie ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARYLTHIENO[3,2 D]PYRIMIDINE; 3,6 DIHYDRO 2H PYRAN; 6 ARYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; ADENOSINE TRIPHOSPHATE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MORPHOLINE DERIVATIVE; PYRAN DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HINGE REGION; MOLECULAR MODEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; COMPUTER SIMULATION; DRUG DISCOVERY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROSOMES; MODELS, MOLECULAR; MORPHOLINES; PROTEIN-SERINE-THREONINE KINASES; PYRANS; PYRAZOLES; PYRIDINES; PYRIMIDINES;

MAMMALIA;

EID: 72249090391     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.050     Document Type: Article

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