Phase-separated chitosan-fibrin microbeads for cell delivery

Journal of Microencapsulation

Volumn 28, Issue 5, 2011, Pages 344-352

  Chen, Zhewei ^a   Wang, Limin ^a   Stegemann, Jan P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cell therapy; Matrix; Microsphere; Regenerative medicine; Tissue engineering

Indexed keywords

CHITOSAN; DIMETICONE; FIBRIN; NANOCOMPOSITE; NANOPARTICLE; PROTEIN; THROMBIN;

ARTICLE; CELL SPREADING; CELL STRUCTURE; CELL SUSPENSION; CELL VIABILITY; CONCENTRATION (PARAMETERS); EMULSION; EXTRACELLULAR MATRIX; FIBROBLAST; GELATION; HUMAN; HUMAN CELL; LIQUID; MOLECULAR INTERACTION; NANOFABRICATION; NEWBORN; PH; PHASE SEPARATION; POLYMERIZATION; VELOCITY;

CELL SURVIVAL; CELL TRANSPLANTATION; CELLS, IMMOBILIZED; CHITOSAN; EXTRACELLULAR MATRIX; FIBRIN; FIBROBLASTS; HUMANS; MICROSPHERES; PARTICLE SIZE; PHASE TRANSITION; POLYMERIZATION; TISSUE THERAPY; WOUND HEALING;

EID: 79960244442     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2011.569764     Document Type: Article

References (40)

1. Addo RT, Siddig A, Siwale R, Patel NJ, Akande J, Uddin AN, DSouza MJ. Formulation, characterization and testing of tetracaine hydrochlorideloaded albumin-chitosan microparticles for ocular drug delivery. J Microencapsulation, 2010;27:95-104.
2. Ahmed TA, Dare EV, Hincke M. Fibrin: A versatile scaffold for tissue engineering applications. Tissue Eng Part B Rev, 2008;14:199-215. (Pubitemid 351839214)
3. Batorsky A, Liao J, Lund AW, Plopper GE, Stegemann JP. Encapsulation of adult human mesenchymal stem cells within collagen-agarose microenvironments. Biotechnol Bioeng, 2005;92:492-500. (Pubitemid 41737240)
4. Berger J, Reist M, Mayer JM, Felt O, Gurny R. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm, 2004;57:35-52. (Pubitemid 38058802)
5. Breen A, Obrien T, Pandit A. Fibrin as a delivery system for therapeutic drugs and biomolecules. Tissue Eng Part B Rev, 2009;15:201-14.
6. Breslauer DN, Muller SJ, Lee LP. Generation of monodisperse silk microspheres prepared with microfluidics. Biomacromolecules, 2010; 11:643-7.
7. Chan BP, Hui TY, Wong MY, Yip KH, Chan GC. Mesenchymal stem cellencapsulated collagen microspheres for bone tissue engineering. Tissue Eng Part C Methods, 2010;16:225-35.
8. Chavakis E, Koyanagi M, Dimmeler S. Enhancing the outcome of cell therapy for cardiac repair: Progress from bench to bedside and back. Circulation, 2010;121:325-35.
9. Choi CH, Jung JH, Rhee YW, Kim DP, Shim SE, Lee CS. Generation of monodisperse alginate microbeads and in situ encapsulation of cell in microfluidic device. Biomed Microdevices, 2007;9:855-62. (Pubitemid 350020680)
10. Costa-Pinto AR, Correlo VM, Sol PC, Bhattacharya M, Charbord P, Delorme B, Reis RL, Neves NM. Osteogenic differentiation of human bone marrow mesenchymal stem cells seeded on melt based chitosan scaffolds for bone tissue engineering applications. Biomacromolecules, 2009;10:2067-73.
11. Cummings CL, Gawlitta D, Nerem RM, Stegemann JP. Properties of engineered vascular constructs made from collagen, fibrin, and collagenfibrin mixtures. Biomaterials, 2004;25:3699-706. (Pubitemid 38327058)
12. Gorodetsky R, Clark RA, An J, Gailit J, Levdansky L, Vexler A, Berman E, Marx G. Fibrin microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing. J Invest Dermatol, 1999; 112:866-72. (Pubitemid 29277985)
13. Gorodetsky R, Vexler A, Levdansky L, Marx G. Fibrin microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing. Methods Mol Biol, 2004;238:11-24.
14. Gurevich O, Vexler A, Marx G, Prigozhina T, Levdansky L, Slavin S, Shimeliovich I, Gorodetsky R. Fibrin microbeads for isolating and growing bone marrow-derived progenitor cells capable of forming bone tissue. Tissue Eng, 2002;8:661-72. (Pubitemid 34857802)
15. Hong H, Stegemann JP. 2D and 3D collagen and fibrin biopolymers promote specific ECM and integrin gene expression by vascular smooth muscle cells. J Biomater Sci Polym Ed, 2008;19:1279-93.
16. Huang NF, Chu J, Lee RJ, Li S. Biophysical and chemical effects of fibrin on mesenchymal stromal cell gene expression. Acta Biomater, 2010; 6:3947-56.
17. Jiang T, Kumbar SG, Nair LS, Laurencin CT. Biologically active chitosan systems for tissue engineering and regenerative medicine. Curr Top Med Chem, 2008;8:354-64. (Pubitemid 351791029)
18. Kurita K. Chitin and chitosan: Functional biopolymers from marine crustaceans. J Mar Biotechnol (NY), 2006;8:203-26. (Pubitemid 43881826)
19. Laurens N, Koolwijk P, De Maat MP. Fibrin structure and wound healing. J Thromb Haemost, 2006;4:932-9.
20. Lavertu M, Filion D, Buschmann MD. Heat-induced transfer of protons from chitosan to glycerol phosphate produces chitosan precipitation and gelation. Biomacromolecules, 2008;9:640-50. (Pubitemid 351298489)
21. Lee K, Chan CK, Patil N, Goodman SB. Cell therapy for bone regeneration - bench to bedside. J Biomed Mater Res B Appl Biomater, 2009; 89:252-63.
22. Livoti CM, Morgan JR. Self-assembly and tissue fusion of toroid-shaped minimal building units. Tissue Eng Part A, 2010;16:2051-61.
23. Lund AW, Bush JA, Plopper GE, Stegemann JP. Osteogenic differentiation of mesenchymal stem cells in defined protein beads. J Biomed Mater Res B Appl Biomater, 2008;87:213-21.
24. Lund AW, Yener B, Stegemann JP, Plopper GE. The natural and engineered 3D microenvironment as a regulatory cue during stem cell fate determination. Tissue Eng Part B Rev, 2009;15:371-80.
25. Madihally SV, Matthew HW. Porous chitosan scaffolds for tissue engineering. Biomaterials, 1999;20:1133-42. (Pubitemid 29233382)
26. Maeng YJ, Choi SW, Kim HO, Kim JH. Culture of human mesenchymal stem cells using electrosprayed porous chitosan microbeads. J Biomed Mater Res A, 2010;92:869-76.
27. Mark D, Haeberle S, Zengerle R, Ducree J, Vladisavljevic GT. Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle. J Colloid Interface Sci, 2009;336:634-41.
28. Mazumder MA, Burke NA, Shen F, Potter MA, Stover HD. Core-crosslinked alginate microcapsules for cell encapsulation. Biomacromolecules, 2009;10:1365-73.
29. Mcguigan AP, Bruzewicz DA, Glavan A, Butte MJ, Whitesides GM. Cell encapsulation in sub-mm sized gel modules using replica molding. PLoS One, 2008;3:e2258.
30. Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost, 2005;3:1894-904. (Pubitemid 41716577)
31. Nair LS, Starnes T, Ko JW, Laurencin CT. Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications. Biomacromolecules, 2007;8:3779-85.
32. Natesan S, Baer DG, Walters TJ, Babu M, Christy RJ. Adipose-derived stem cell delivery into collagen gels using chitosan microspheres. Tissue Eng Part A, 2010;16:1369-84.
33. Nichol JW, Khademhosseini A. Modular tissue engineering: Engineering biological tissues from the bottom up. Soft Matter, 2009;5:1312-9.
34. Perka C, Arnold U, Spitzer RS, Lindenhayn K. The use of fibrin beads for tissue engineering and subsequential transplantation. Tissue Eng, 2001;7:359-61. (Pubitemid 32574933)
35. Rowe SL, Lee S, Stegemann JP. Influence of thrombin concentration on the mechanical and morphological properties of cell-seeded fibrin hydrogels. Acta Biomater, 2007;3:59-67. (Pubitemid 44804296)
36. Sakai S, Kawabata K, Ono T, Ijima H, Kawakami K. Development of mammalian cell-enclosing subsieve-size agarose capsules (5100 micron) for cell therapy. Biomaterials, 2005;26:4786-92. (Pubitemid 40343027)
37. Solorio L, Zwolinski C, Lund AW, Farrell MJ, Stegemann JP. Gelatin microspheres crosslinked with genipin for local delivery of growth factors. J Tissue Eng Regen Med, 2010;4:514-23.
38. Wang L, Stegemann JP. Thermogelling chitosan and collagen composite hydrogels initiated with beta-glycerophosphate for bone tissue engineering. Biomaterials, 2010;31:3976-85.
39. Yamaguchi I, Itoh S, Suzuki M, Sakane M, Osaka A, Tanaka J. The chitosan prepared from crab tendon I: The characterization and the mechanical properties. Biomaterials, 2003;24:2031-6. (Pubitemid 36298773)
40. Yu J, Du KT, Fang Q, Gu Y, Mihardja SS, Sievers RE, Wu JC, Lee RJ. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials, 2010;31:7012-20.