Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle

Journal of Colloid and Interface Science

Volumn 336, Issue 2, 2009, Pages 634-641

  Mark, Daniel ^a   Haeberle, Stefan ^a   Zengerle, Roland ^a,b   Ducree, Jens ^a,b   Vladisavljević, Goran T ^c,d  

^a Institute of Micromachining and Information Technology   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Centrifugal; Chitosan; Encapsulation; Hydrogel microbeads; Ionotropic gelation; Microfluidics; Monodisperse drops

Indexed keywords

ANALYTICAL MODEL; CENTRIFUGAL; CENTRIFUGAL FIELDS; CHITOSAN BEADS; CHITOSAN SOLUTION; EXPERIMENTAL DATA; FLOW BEHAVIOUR INDEX; INNER DIAMETERS; IONOTROPIC GELATION; MICROBEADS; MICRONOZZLE; MONODISPERSE DROPS; NON-NEWTONIAN; PRODUCTION PROCESS; PRODUCTION RATES; PULSE-FREE FLOW; REPRODUCIBILITY; ROTOR FREQUENCY; THEORETICAL MODELS; TRIPOLYPHOSPHATE;

CENTRIFUGATION; CHITIN; CHITOSAN; COAGULATION; DROPS; FORMING; GELATION; NON NEWTONIAN FLOW; NOZZLES; POLYMERS; RANGE FINDING;

HYDROGELS;

CHITOSAN; TRIPOLYPHOSPHATE;

ARTICLE; CENTRIFUGATION; EQUIPMENT DESIGN; FLOW KINETICS; GELATION; HYDROGEL; MICROFLUIDICS; PARTICLE SIZE; PRIORITY JOURNAL;

CHITOSAN; MANUFACTURED MATERIALS; METHODS; MICROSPHERES; PARTICLE SIZE; RHEOLOGY;

EID: 67649132603     PISSN: 00219797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcis.2009.04.029     Document Type: Article

References (49)

1. Fukui S., and Tanaka A. Ann. Rev. Microbiol. 36 (1982) 145
2. Sriamornsak P., and Nunthanid J. Int. J. Pharm. 160 (1998) 207
3. Khademhosseini A., and Langer R. Biomaterials 28 (2007) 5087
4. Ayi T.C., Tong J.M.M., and Lee P.V.S. Proc. SPIE 6218 (2006) 62180K
5. Bayramoglua G., Denizli A., Bektas S., and Arica M.Y. Microchem. J. 72 (2002) 63
6. Ogbonna J.C., Matsumura M., Yamagata T., Sakuma H., and Kataoka H. J. Ferment. Bioeng. 68 (1989) 40
7. Poncelet D., Lencki R., Beaulieu C., Halle J.P., Neufeid R.J., and Fournier A. Appl. Microbiol. Biotechnol. 38 (1992) 39
8. Rehg T., Dorger C., and Chau P.C. Biotechnol. Lett. 8 (1986) 111
9. Fumi M.D., Silva A., Battistotti G., and Colagrande O. Biotechnol. Lett. 14 (1992) 605
10. Lee H.H., Park O.J., Park J.M., and Yang J.W. J. Chem. Technol. Biotechnol. 67 (1996) 255
11. Dulieu C., Poncelet D., and Neufeld R.J. In: Kühtreiber W.M., Lanza R.P., and Chick W.L. (Eds). Cell Encapsulation Technology and Therapeutics (1999), Birkhäuser, Boston 3
12. Yeh J., Ling Y., Karp J.M., Gantz J., Chandawarkar A., Eng G., Blumling III J., Langer R., and Khademhosseini A. Biomaterials 27 (2006) 5391
13. Koh W.G., Revzin A., and Pishko M.V. Langmuir 18 (2002) 2459
14. Zhang H., Tumarkin E., Sullan R.M.A., Walker G.C., and Kumacheva E. Macromol. Rapid Commun. 28 (2007) 527
15. Utada A.S., Lorenceau E., Link D.R., Kaplan P.D., Stone H.A., and Weitz D.A. Science 308 (2005) 537
16. Shepherd R.F., Conrad J.C., Rhodes S.K., Link D.R., Marquez M., Weitz D.A., and Lewis J.A. Langmuir 22 (2006) 8618
17. Ikkai F., Iwamoto S., Adachi E., and Nakajima M. Colloid Polym. Sci. 283 (2005) 1149
18. Vladisavljević G.T., Kobayashi I., Nakajima M., Williams R.A., Shimizu M., and Nakashima T. J. Membr. Sci. 302 (2007) 243
19. Nakashima T., Shimizu M., and Kukizaki M. Adv. Drug Deliv. Rev. 6 (2000) 47
20. Qiu C., Chen M., Yan H., and Wu H. Adv. Mater. 19 (2007) 1603
21. De Geest B.G., Urbanski J.P., Thorsen T., Demeester J., and De Smedt S.C. Langmuir 21 (2005) 10275
22. Iwamoto S., Nakagawa K., Sugiura S., and Nakajima M. AAPS PharmSci 3 (2002) 1 (Article 25)
23. Wang L.Y., Ma G.H., and Su Z.G. J. Control. Release 106 (2005) 62
24. Zhou Q.Z., Wang L.Y., Ma G.H., and Su Z.G. J. Colloid Interface Sci. 311 (2007) 118
25. Kim J.W., Utada A.S., Fernández-Nieves A., Hu Z., and Weitz D.A. Angew. Chem. Int. Ed. 46 (2007) 1819
26. Kim J.W., Fernández-Nieves A., Dan N., Utada A.S., Marquez M., and Weitz D.A. Nano Lett. 7 (2007) 2876
27. Um E., Lee D.S., Pyo H.B., and Park J.K. Microfluid. Nanofluid. 5 (2008) 541
28. Surh J., Vladisavljević G.T., Mun S., and McClements D.J. J. Agric. Food Chem. 55 (2007) 175
29. Kobayashi I., Uemura K., and Nakajima M. Food Biophys. 3 (2008) 132
30. Choi C.H., Jung J.H., Rhee Y.W., Kim D.P., Shim S.E., and Lee C.S. Biomed. Microdevices 9 (2007) 855
31. Sugiura S., Oda T., Aoyagi Y., Matsuo R., Enomoto T., Matsumoto K., Nakamura T., Satake M., Ochiai A., Ohkohchi N., and Nakajima M. Biomed. Microdevices 9 (2007) 91
32. Huang K.S., Lai T.H., and Lin Y.C. Lab Chip 6 (2006) 954
33. Liu X.D., Bao D.C., Xue W.M., Xiong Y., Yu W.T., Yu X.J., Ma X.J., and Yuan Q.J. Appl. Polym. Sci. 87 (2003) 848
34. Zhang H., Tumarkin E., Peerani R., Nie Z., Sullan R.M.A., Walker G.C., and Kumacheva E. J. Am. Chem. Soc. 128 (2006) 12205
35. Sugiura S., Oda T., Izumida Y., Aoyagi Y., Satake M., Ochiali A., Ohkohchi N., and Nakajima M. Biomaterials 26 (2005) 3327
36. S. Haeberle, L. Naegele, R. Burger, R. Zengerle, J. Ducrée, in: Proceedings of the 19th MEMS, Kobe, 2007, p. 497.
37. Haeberle S., Naegele L., Burger R., von Stetten F., Zengerle R., and Ducrée J. J. Microencapsul. 25 (2008) 267
38. Ko J.A., Park H.J., Hwang S.J., Park J.B., and Lee J.S. Int. J. Pharm. 249 (2002) 165
39. Patel C.B., and Gaikar V.G. Sep. Sci. Technol. 39 (2004) 2655
40. Shi Y.C., Jiang Y.M., Sui D.X., Li Y.L., Chen T., Ma L., and Ding Z.T. J. Chromatogr. A 742 (1996) 107
41. Ngah W.S.W., Endud C.S., and Mayanar R. React. Funct. Polym. 50 (2002) 181
42. He P., Davis S.S., and Illum L. Int. J. Pharm. 187 (1999) 53
43. Baruch L., and Machluf M. Biopolymers 82 (2006) 570
44. Vorlop K.D., and Klein J. Biotechnol. Lett. 3 (1981) 9
45. Bodmeier R., and Paeratakul O. J. Pharm. Sci. 78 (1989) 964
46. Hassan E.E., Parish R.C., and Gallo J.M. Pharm. Res. 9 (1992) 390
47. Yang C.H., Huang K.S., and Chang J.Y. Biomed. Microdevices 9 (2007) 253
48. Hwang J.K., and Shin H.H. Korea-Aust. Rheol. J. 12 (2000) 175
49. Nielsen L.E. Polymer Rheology (1977), Marcell Dekker, New York p. 48