Formulation, characterization and testing of tetracaine hydrochloride-loaded albumin-chitosan microparticles for ocular drug delivery

Journal of Microencapsulation

Volumn 27, Issue 2, 2010, Pages 95-104

  Addo, Richard T ^a   Siddig, Aladin ^b   Siwale, Rodney ^c   Patel, Neil J ^c   Akande, Janet ^c   Uddin, Akm N ^d   D'Souza, Martin J ^c  

^a SHENANDOAH UNIVERSITY   (United States)

^b Robert C Byrd Center for Pharmacy Education   (United States)

^c MERCER UNIVERSITY   (United States)

^d Barr Pharmaceuticals   (United States)

Author keywords

Albumin; Chitosan; Microparticles; Tetracaine

Indexed keywords

BOVINE SERUM ALBUMIN; CHITOSAN; NANOPARTICLE; TETRACAINE; DRUG CARRIER; EYE DROPS; LOCAL ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MECHANISM; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; DRUG UPTAKE; EYE SURGERY; HUMAN; HUMAN CELL; MICROENCAPSULATION; MICROMORPHOLOGY; NONHUMAN; PARTICLE SIZE; SPRAY DRYING; SURGICAL TECHNIQUE; THERMOSTABILITY; ZETA POTENTIAL; ANIMAL; BOVINAE; CELL LINE; CELL SURVIVAL; CHEMISTRY; CORNEA; CYTOLOGY; DRUG STABILITY; EPITHELIUM CELL; EYE; METABOLISM; PROCEDURES; RABBIT;

ANESTHETICS, LOCAL; ANIMALS; CATTLE; CELL LINE; CELL SURVIVAL; CHITOSAN; CORNEA; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EPITHELIAL CELLS; EYE; HUMANS; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; RABBITS; SERUM ALBUMIN, BOVINE; TETRACAINE;

EID: 77149128040     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652040903010638     Document Type: Article

References (22)

1. Ahsan F, Rivas IP, Khan MA, Torres Suarez AI. 2002. Targeting to macrophages: Role of physicochemical properties of particulate carriers- liposomes and microspheres-on the phagocytosis by macrophages. J Contr Rel 79:29-40.
2. Arshady R. 1990. Albumin microspheres and microcapsules: Methodology of manufacturing techniques. J Contr Re 14:111-131. (Pubitemid 20353562)
3. Beaman JM, Akhtar N, Goldie DJ. 1996. Down's syndrome screening using free beta hCG: Instability can significantly increase the Down's risk estimate. Ann Clin Biochem 33:525-529.
4. Brandao J, Mogo C, Silva BC. 2004. Potential energy surface for H2O((3)A(")) from accurate ab initio data with inclusion of longrange interactions. J Chem Phys 121:8861-8868.
5. Burger JJ, Tomlinson E, de Roo JE, Palmer J. 1985. Technetium-99m labeling of albumin microspheres intended for drug targeting. Methods Enzymol 112:43-56.
6. Calvo P, Alonso MJ, Vila-Jato JL, Robinson JR. 1996. Improved ocular bioavailability of indomethacin by novel ocular drug carriers. J Pharm Pharmacol 48:1147-1152.
7. de Campos AM, Diebold Y, Carvalho EL, Sanchez A, Alonso MJ. 2004. Chitosan nanoparticles as new ocular drug delivery systems: In vitro stability, in vivo fate, and cellular toxicity. Pharm Res 21:803-810.
8. de Silva LP, Ciocca Mde L, Furlong EB. 2003. Evaluation of the AOAC 985.29 enzimic gravimetric method for determination of dietary fiber in oat and corn grains. Arch Latinoam Nutr 53:393-399.
9. Enriquez de Salamanca A, Diebold Y, Calonge M, Garcia-Vazquez C, Callejo S, Uila A, et al. 2006. Chitosan nanoparticles as a potential drug delivery system for the ocular surface: Toxicity, uptake mechanism and in vivo tolerance. Invest Ophthalmol Vis Sci 47:1416-1425.
10. Gupta PK, Hung CT. 1989. Albumin microspheres. II: Applications in drug delivery. J Microencapsulation 6:463-472.
11. Harmia T, Speiser P, Kreuter J. 1986. A solid colloidal drug delivery system for the eye: Encapsulation of pilocarpin in nanoparticles. J Microencapsulation 3:3-12.
12. Jha SK, D'Souza SF. 2005. Preparation of polyvinyl alcohol-polyacrylamide composite polymer membrane by gamma-irradiation for entrapment of urease. J Biochem Biophys Methods 62:215-218.
13. Kramer PA. 1974. Letter: Albumin microspheres as vehicles for achieving specificity in drug delivery. J Pharm Sci 63:1646-1647.
14. Lim ST, Martin GP, Berry DJ, Brown MB. 2000. Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. J Contr Rel 66:281-292.
15. Losa C, Calvo P, Castro E, Vila-Jato JL, Alonso MJ. 1991. Improvement of ocular penetration of amikacin sulphate by association to poly(butylcyanoacrylate) nanoparticles. J Pharm Pharmacol 43:548-552.
16. Losa C, Marchal-Heussler L, Orallo F, Vila Jato JL, Alonso MJ. 1993. Design of new formulations for topical ocular administration: Polymeric nanocapsules containing metipranolol. Pharm Res 10:80-87.
17. Maury M, Murphy K, Kumar S, Shi L, Lee G. 2005. Effects of process variables on the powder yield of spray-dried trehalose on a laboratory spray-dryer. Eur J Pharm Biopharm 59:565-573.
18. Natsume H, Sugibayashi K, Morimoto Y. 1990. Preparation and evaluation of biodegradable albumin microspheres containing mitomycin C. Int J Pharm 58:79-87.
19. Sanchez A, Tobio M, Gonzalez L, Fabra A, Alonso MJ. 2003. Biodegradable micro- and nanoparticles as long-term delivery vehicles for interferonalpha. Eur J Pharm Sci 18:221-229.
20. Verma S, Corbett MC, Marshall J. 1995. A prospective, randomized, double-masked trial to evaluate the role of topical anesthetics in controlling pain after photorefractive keratectomy. Ophthalmology 102:1918-1924.
21. Zimmer A, Mutschler E, Lambrecht G, Mayer D, Kreuter J. 1994. Pharmacokinetic and pharmacodynamic aspects of an ophthalmic pilocarpine nanoparticle-delivery-system. Pharm Res 11:1435-1442.
22. Zolle I, Rhodes BA, Wagner HN, Jr. 1970. Preparation of metabolizable radioactive human serum albumin microspheres for studies of the circulation. Int J Appl Radiat Isot 21:155-167.