Systems biology reveals biology of systems

Complexity

Volumn 16, Issue 6, 2011, Pages 10-16

  Bertolaso, Marta ^a   Giuliani, Alessandro ^b   De Gara, Laura ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Biological complexity; Scientific activity; Systemic perspective; Systems biology; Theory formation

Indexed keywords

EID: 79960234718     PISSN: 10762787     EISSN: 10990526     Source Type: Journal    
DOI: 10.1002/cplx.20353     Document Type: Note

References (33)

1. Wilkins, A.S. For the biotechnology industry, the penny drops (at last): Genes are not autonomous agents but function within networks! Bioessays 2007, 29, 1179-1181.
2. Wingreen, N.;Botstein, D. Back to the future: Education for systems-level biologists. Nat Rev Mol Cell Biol 2006, 7, 829-832.
3. Reijenga, K.A.;Bakker, B.M.;van der Weijden, C.C.;Westerhoff, H.V. Training of yeast cell dynamics. FEBS J 2005, 272, 1616-1624.
4. Westerhoff, H.V.;Kell, D.B. The methodologies of systems biology. In: Systems Biology; Boogerd, F.C.;Bruggeman, F.J.;Hofmeyer, J.H.S.;Westerhoff, H.V., Eds.; Philosophical Foundations: Elsevier, 2007; pp 23-70.
5. Giuliani, A. Collective motions and specific effectors: A statistical mechanics perspective on biological regulation. BMC Genomics 2010, 11 (Suppl 1), S2; Doi: 10.1186/1471-2164-11-S1-S2.
6. Lynch, I.;Salvati, A.;Dawson, K.A. Protein-nanoparticle interactions: What does the cell see? Nat Nanotechnol 2009, 4, 546-547.
7. Alon, U. An Introduction to Systems Biology: Design Principles of Biological Circuits; Boca Raton: Chapman and Hall/CRC, 2007.
8. Hanahan, D.;Weinberg, R.A. The hallmarks of cancer. Cell 2000, 100, 57-70.
9. Kitano, H. Cancer as a robust system: Implications for anticancer therapy. Nat Rev Cancer 2004, 4, 227-235.
10. Kritikou, E. All systems go! System Biology: A user's guide. Nat Rev Mol Cell Biol 2006, 7, 801.
11. Bizzarri, M.;Cucina, A.;Conti, F.;D'Anselmi, F. Beyond the oncogene paradigm: Understanding complexity in cancerogenesis. Acta Biotheor 2008, 56, 173-196.
12. Boogerd, F.C.;Bruggeman, F.J.;Hofmeyer, J.-H.S.;Westerhoff, H.V., Eds. Systems Biology; Philosophical foundations: Elsevier, 2007; p 6.
13. Bertalanffy L. Von, General System Theory; New York: Braziller, 1968.
14. Ashby W.R. An Introduction to Cybernetics; London: Chapman and Hall Ltd, 1956.
15. Schrödinger, E. What is Life? The Physical Aspect of the Living Cell; Cambridge: Cambridge University Press, 1944.
16. Heinrich, R.;Neel, B.G.;Rapoport, T.A. Mathematical models of protein kinase signal transduction. Mol Cell 2002, 9, 957-970.
17. Heinrich, R.;Rapoport, T.A. A linear steady-state treatment of enzymatic chains. Critique of the crossover theorem and a general procedure to identify interaction sites with an effector. Eur J Biochem 1974, 42, 89-95.
18. Milestone in Development, Nature Milestones, 10: Available at:, 2004. Accessed on July 16, 2008.
19. Ideker, T.;Thorsson, V.;Ranish, J.A.;Christmas, R.;Buhler, J.;Eng, R.;Bumgarner, J.K.;Goodlett, D.R.;Aebersold, R.;Hood, L. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 2001, 292, 929-934.
20. Strange, K. The end of "naïve reductionism": Rise of systems biology or renaissance of physiology? Am J Physiol Cell Physiol 2004, 288, 968-974.
21. Gilbert, S.F.;Sarkar, S. Embracing complexity: Organicism for the 21st century. Dev Dyn 2000, 219, 1-9.
22. Brisken, C.;Socolovsky, M.;Lodish, H.F.;Weinberg, R. The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium. Proc Natl Acad Sci USA 2000, 99, 14241-14245.
23. Dawkins, R. The Selfish Gene; Oxford: Oxford University Press, 1976.
24. Griffiths, P.E.;Gray, R.D. Darwinism and developmental systems. In: Cycles of Contingency: Developmental Systems and Evolution Cambridge; Oyama, S.;Griffiths, P.E.;Gray, R.D., Eds.; Cambridge, MA: MIT Press, 2000; pp 195-218.
25. Abbs, S.;Bussoli, T.;Kavalier, F. Nature Encyclopaedia of the human genome. Br Med J 2004, 328, 172.
26. Bloom, F.E. What does it all mean to you? J Neurosci 2001, 21, 8304-8305.
27. Papin, J.A.;Hunter, T.;Palsson, B.O.;Subramaniam, S. Reconstruction of cellular signalling networks and analysis of their properties. Nat Rev Mol Cell Biol 2005, 6, 99-111.
28. Kitano, H. Computational systems biology. Nature 2002, 420, 206-210.
29. Amit, I.;Wides, R.;Yarden, Y. Evolvable signaling networks of receptor tyrosine kinases: Relevance of robustness to malignancy and to cancer therapy. Mol Syst Biol 2007, 3, 1-13.
30. Hood, L.;Heath, J.R.;Phelps, M.E.;Lin, B. System biology and the new technologies enable predictive and preventative medicine. Science 2004, 306, 640-643.
31. Yuan, J.S.;Galbraith, D.W.;Dai, S.Y.;Griffin, P.;Stewart, C.N., Jr. Plant systems biology comes of age. Trends Plant Sci 2008, 13, 165-171.
32. Overington, J.P.;Al-Lazikani, B.;Hopkins, A.L. How many drug targets are there? Nat Rev Drug Discov 2006, 5, 993-996.
33. Csermely, P.;Agoston, V.;Pongor, S. The efficiency of multi-target drugs: The network approach might help drug design. Trends Pharmacol Sci 2005, 26, 178-182.